Abstract: The present invention relates to a compound of the formula I Wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: Disclosed herein are various techniques for transforming single cell data into insights about the single cell data, and wherein the one or more insights are derived from medical papers and/or medical ontologies that are relevant to the single cell data. Underlying this transformation is a network model of related phenotypes derived from the single cell data, where the network model exhibits a network structure that defines connections between related phenotypes of the network model. This network structure can be leveraged to meaningfully synthesize the single cell data with external knowledge such as medical literature and medical ontologies in a contextual manner.

Abstract: A multi-agent system for transforming single call data insights about phenotypes exhibited by the single cell data can comprise one or more processors and databases, the database(s) configured to provide linkages between (1) phenotype data for phenotypes derived from the single cell data and (2) external knowledge about the phenotypes derived from medical literature. The system can include first, second, and third agents configured for operating in parallel with each other; the first agent(s) configured to transform the single cell data into the phenotype data; the second agent(s) configured to process a medical literature corpus using NLP to determine information relating to the phenotypes described by the medical literature, wherein the external knowledge comprises the determined information; and the third agent(s) configured to synthesize insight(s) about the single cell data with respect to one or more phenotypes of interest, wherein the insight(s) are derived from the linkages in the database(s).

Abstract: Described herein are systems and techniques for estimating a shape of a structure undergoing dynamic stress. In some embodiments, a method includes: for each of a plurality of nodes distributed along a length of the structure, obtaining, from an accelerometer located at the node, a tilt angle corresponding to an angle between a local axis of the structure and a direction of gravity; calculating, by a microcontroller, vertical displacements between adjacent pairs of the plurality of nodes using the respective tilt angles obtained for the adjacent pairs; and calculating, by the microcontroller, a depth of each of the plurality of nodes relative to a proximal end of the structure by adding the vertical displacements calculated for adjacent pairs of the plurality of nodes between the node and the proximal end of the structure.

Abstract: A seal assembly includes a first wall extending from a compression side to a fastened side of the seal assembly, a second wall interior of the first wall and extending from the compression side to the fastened side of the seal assembly, and a stiffening member embedded within the second wall adjacent to the compression side of the seal assembly. When the seal assembly is pressurized, the first wall and the second wall define an insulated pocket.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Methods and systems in which a portable electronic device can be voice activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

Abstract: An inhalation device for inhaling a vaporized substance that includes metering capabilities to inform a user when a particular amount of substance has been consumed. The inhalation device can include a sensor that senses the vaporized substance and a processor that utilizes data from the sensor to meter the amount consumed. The inhalation device can also define a session, which is a time in which a user can consume a particular amount. During the session, a user can start and stop inhaling and resume inhaling. When the user stops inhaling the inhalation device will halt vapor production and will resume production when the user resumes inhaling.

Abstract: Methods and systems in which a portable electronic device can be voice activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

Abstract: The invention relates to 4-((6-(2,2-Difluoroethyl)-8-(2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidine-1-sulfonamide or pharmaceutically acceptable salts thereof, to compositions containing them, to processes for their preparation, to intermediates used in such processes, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer. The disclosure also relates to its crystalline form 1, to pharmaceutical compositions comprising form 1, and to the use of form 1 for the treatment of cancers.

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: A key-duplicating system comprises a network that includes a multiplicity of kiosks at a multiplicity of different locations, each of the kiosks having a customer interface and a processor coupled to the customer interface. A remote central server coupled to the kiosks is adapted to receive, from the kiosks, information identifying master keys to be duplicated. A key analysis module uses the information identifying master keys to be duplicated to derive information required to produce duplicates of the identified master keys, and a key duplicating module uses that information to produce duplicates of said identified master keys.

Abstract: An inhalation device for e.g., nicotine products which receives a user input regulating the amount of nicotine the user wants to receive. Once the selected amount has been delivered to the user, the device shuts off its atomizer to conclude operation.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Methods and systems in which a portable electronic device can be voice activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Electrospray devices and methods of fabricating electrospray devices are described.

Abstract: Methods and systems in which a portable electronic device can be voice activated are disclosed. The portable electronic device can be a multi-function electronic device. The voice activation can be robust and context sensitive. The voice activation can also be utilized without any preparatory user action with respect to the portable electronic device. The portable electronic device can also interact with a media system.

Abstract: The present disclosure provides a computer-implemented method for determining an optimized list of sets of hyperparameter values for application to an additional machine learning task. The method includes obtaining data describing a plurality of different machine learning tasks. The method includes obtaining a plurality of candidate sets of hyperparameter values. The method includes determining an ordered list of sets of hyperparameters selected from the plurality of candidate sets of hyperparameter values, wherein the ordered list of sets of hyperparameters minimizes an aggregate loss over the plurality of different machine learning tasks. The method includes storing the ordered list of sets of hyperparameters for use in training an additional machine learning model to perform an additional machine learning task.

Abstract: A seal assembly includes a first wall extending from a compression side to a fastened side of the seal assembly, a stiffening member embedded within the first wall adjacent to the compression side of the seal assembly, and a second wall exterior of the first wall and extending from the compression side to the fastened side of the seal assembly. When the seal assembly is pressurized, the first wall and the second wall define an insulated pocket.