Abstract: A cap assembly for conveying air into the interior of a container and water from the interior of the container, the cap assembly comprising a valve moveable from a first position, in which the cap assembly is closed, to a second position, in which the cap assembly is open to permit the flow of air and water through the cap assembly, the cap assembly further comprising at least two apertures through which the air and water can flow when the cap assembly is open, wherein the apertures are offset with respect to one another in a direction along the longitudinal axis of the cap assembly.

Abstract: Service items and utensil combinations are provided for efficiency of food service and for selective presentation of foods. Service items include at least a side wall defining an inside surface for receiving food, wherein the side wall is provided with an indentation that extends at least partially over a width of the sidewall for defining a utensil receiving recess along an outside surface of the sidewall, and a recessed edge portion provided along a peripheral edge of the sidewall providing access to the utensil receiving recess. The recessed edge portion can be defined by an edge portion of the peripheral edge and a plurality of opposed capture points. One or more utensils are provided in combination with the service item, wherein each utensil has a portion thereof that is dimensioned to be supported on the edge portion defining the recessed edge portion adjacent to the opposed capture points.

Abstract: The present disclosure provides methods and compositions for the treatment of cancer. In some aspects, the present disclosure provides splice-switching oligonucleotides that downregulate AR or EGFR expression and methods of using these splice-switching oligonucleotides to treat cancer.

Abstract: A downhole actuator (30) comprises a tubular housing (34) which includes an indexing profile (42) on an inner surface thereof, and an indexing sleeve (46) mounted within the housing (34). The indexing sleeve (46) comprises an engaging arrangement including first and second axially spaced engagement members (52, 54) which cooperate with the indexing profile (42) of the housing (34) to be sequentially engaged by an actuation object (48) passing through a central bore (50) of the indexing sleeve (46) to drive the indexing sleeve (46) one discrete step of movement through the housing (34) towards an actuation site.

Abstract: A system or apparatus for use in downhole communication or detection comprises a downhole arrangement defining a throughbore and primary and secondary elements. One of the primary and secondary elements is provided on the downhole arrangement and the other of the primary and secondary elements is provided in the throughbore. The primary and secondary elements are configurable for coupling of an electromagnetic field therebetween. The primary or secondary element which is provided in the throughbore may be provided on a tool such as a shifting tool which is deployable through the throughbore. The secondary element may be configured to provide the electromagnetic field coupled between the first and second elements with one or more characteristic features. The system may be configured for use, in particular though not exclusively, for communicating information to and/or from a downhole tool in an oil or gas well.

Abstract: A screen assembly, such as a downhole/sand screen assembly, comprising first and second screen portions or screens longitudinally coupled together, wherein there is provided a fluid flow path between the first and second screen portions or screen. Optionally, the first and second sleeves are coupled or connected by a centralizer or further sleeve or screen, and/or optionally by or via first and second support ring.

Abstract: A downhole tool (32) comprises a tool housing (34) defining a central bore (35) and including a fluid port (20), and a valve member (40) mounted within the housing (34) and being movable from a closed position in which the fluid port (20) is blocked to an open position in which the fluid port (20) is opened. The tool (32) further comprises a catching arrangement (41) mounted within the housing (34) and comprising one or more radially movable seat members (106), and being configurable from a free configuration in which the seat members (106) permit an object (48) to pass through the tool (32), to a catching configuration in which the seat members (106) catch an object (48) passing through the tool (32).

Abstract: A downhole tool (32) comprises a tool housing (34) defining a central bore (35) and including a fluid port (20), and a valve member (40) mounted within the housing (34) and being moveable from a closed position in which the fluid port (20) is blocked to an open position in which the fluid port (20) is opened. The tool (32) further comprises a catching arrangement (41) mounted within the housing (34) and comprising one or more radially moveable seat members (106), and being configurable from a free configuration in which the seat members (106) permit an object (48) to pass through the tool (32), to a catching configuration in which the seat members (106) catch an object (48) passing through the tool (32).

Abstract: A downhole actuator (30) comprises a tubular housing (34) which includes an indexing profile (42) on an inner surface thereof, and an indexing sleeve (46) mounted within the housing (34). The indexing sleeve (46) comprises an engaging arrangement including first and second axially spaced engagement members (52, 54) which cooperate with the indexing profile (42) of the housing (34) to be sequentially engaged by an actuation object (48) passing through a central bore (50) of the indexing sleeve (46) to drive the indexing sleeve (46) one discrete step of movement through the housing (34) towards an actuation site.

Abstract: The switching device comprises an electronic switch embedded within a downhole tool (100) and an activator for remote switching of the electronic switch. The activator may be a handheld unit that is used at the surface of the wellbore by an operator or may be a wireline run unit. The activator permits wireless and contactless activation of the electronic switch without the need for mechanical switches which could provide a point of failure for the downhole tool. The electronic switch comprises an electronics module and a power source such as one or more batteries wherein in the active configuration, the switch can allow electrical connection between the electronics module and the power source and in the inactive configuration, the switch prevents electrical connection between the electronics module and the power source.

Abstract: A humidifying apparatus comprising a base comprising a chamber, a water tank removably mounted on the base for supplying water to the chamber, an impeller and a motor for driving the impeller to generate an air flow, an inlet duct for conveying the air flow to the chamber, humidifying means for humidifying the air flow with water from the chamber, and an outlet duct for conveying the humidified air flow from the chamber, wherein a lower surface of the water tank, which in use supports the water tank on the base, comprises a recessed portion for receiving water overflow from the chamber.

Abstract: A downhole tool (32) comprises a tool housing (34) defining a central bore (35) and including a fluid port (20), and a valve member (40) mounted within the housing (34) and being moveable from a closed position in which the fluid port (20) is blocked to an open position in which the fluid port (20) is opened. The tool (32) further comprises a catching arrangement (41) mounted within the housing (34) and comprising one or more radially moveable seat members (106), and being configurable from a free configuration in which the seat members (106) permit an object (48) to pass through the tool (32), to a catching configuration in which the seat members (106) catch an object (48) passing through the tool (32).

Abstract: A method of actuating at least one of a plurality of downhole tools connected to at least one hydraulic fluid line is disclosed. The method includes the steps of:— a) providing each of the downhole tools with a control unit comprising a timer which permits fluid communication between the at least one hydraulic fluid line and the downhole tool during a window of time; and b) controlling the pressure in the at least one hydraulic fluid line for at least a sufficient period of time required to at least actuate the said downhole tool, wherein the said sufficient period of time coincides at least partially with the said window of time.

Abstract: The invention relates to a new method of determining in a sample the presence, absence or concentration of one or more target analytes, such as micro-ribonucleic acids (microRNAs or miRNAs). The invention may therefore relate to a multiplex assay for determining the presence or absence of each target analyte in a group of multiple analytess. The invention uses one or more probes comprising a quadruplex and transmembrane pores.

Abstract: A system includes one or more processors configured to be operably coupled to a vehicle system configured to travel along a route during a trip. The vehicle system has a vehicle particulate filter (VPF) disposed within an exhaust passage of the vehicle system. The one or more processors are configured to determine, based on trip information about the trip of the vehicle system, one or more regeneration-incompatible (RI) portions of the trip. The RI portions are associated with operating conditions of the vehicle system that are unsuitable for contemporaneous active regeneration of the VPF. The one or more processors are further configured to schedule an active regeneration (AR) event for the vehicle system based on the one or more RI portions of the trip. The AR event occurs during a regeneration portion of the trip.

Abstract: In some examples, a computing device processes depth images to capture an interaction of an object relative to an interaction plane.

Abstract: A valve assembly (10) comprises a flow path extending from an assembly inlet (20) to an assembly outlet (22), a valve (24a/26a) arranged within the flow path and a filter assembly arranged within the flow path between the assembly inlet and the valve. The filter assembly comprises a filter chamber defining a particle settlement region, a filter chamber inlet for facilitating inflow of a fluid into the chamber, and a filter chamber outlet for facilitating outflow of fluid from the chamber towards the valve, wherein the filter chamber outlet includes a particle filter.

Abstract: A commercial fishing trawl has a net and a mouth opening defined by a head line, a foot line, and side lines. The mouth opening is spread by a plurality of foil segments threaded on one or more of the head line, foot line, or side lines. Foil segments may also be threaded on tag lines or foil lines attached about the mouth opening to spread and maintain the mouth opening as the trawl is towed through the water, behind a tow vessel.