Abstract: Disclosed herein are compositions and methods related to megakaryocyte-derived extracellular vesicles derived from human pluripotent stem cells, where the megakaryocyte-derived extracellular vesicles present unique biomarkers.

Abstract: Disclosed herein are methods related to megakaryocyte-derived extracellular vesicles derived from human pluripotent stem cells. In some aspects the disclosed methods relate to the generation, the purification and cardo loading of the megakaryocyte-derived extracellular vesicles.

Abstract: Disclosed herein are compositions and methods related to gene editing for the treatment of a myeloproliferative disease or disorder. Also disclosed herein are compositions and methods related to the use of megakaryocyte-derived extracellular vesicles for delivery of compositions related to gene editing.

Abstract: A mesh comprising a substantially planar open frame structure formed from a plurality of interlinked planar units, wherein the open frame structure is infinitely increasable in size by the addition of more units, the frame structure comprising three types of units: body units forming the centre/middle part of the frame structure, the body units adapted to interlink with at least 4 other units in the frame structure, peripheral units around the outside edge of the body units, each peripheral unit adapted to interlink with at least 3 other units in the frame structure, corner units at each corner of the outer periphery and therefore linking with peripheral units, each corner unit adapted to interlink with at least 2 other units in the structure, wherein each planar unit is a ring defining an inner opening, the outer surface of the ring supporting interlocking parts wherein a first interlocking part on a first ring arranged in the frame structure aligns and cooperates with a second complementary shaped interlock

Abstract: Example methods and apparatus can be used to reduce noise in motor assemblies, such as those used in architectural coverings. An example apparatus includes a first driver configured to be coupled to and rotated by an output shaft of a motor, a second driver, and a plurality of vibration-absorbers disposed between the first driver and the second driver. The second driver is configured to be coupled to a rotating member to transfer rotational motion from the first driver to the rotating member via the vibration-absorbers.

Abstract: Provided is a digital/analog signal processing apparatus and method for controlling exposure of personally identifiable information to be transferred from storage in a secure enclave, comprising a memory and an integrated circuit coupled to the memory, configured to: select a data set stored in the storage; individuate personally identifiable information in the data set; determine an individual person's subset of personally identifiable information; extract an identifier for the individual person from the subset; interrogate stored data using the identifier to locate metadata comprising permission to expose the individual person's subset; and responsive to a failure to locate the metadata comprising permission, either: emit a signal seeking the permission; or apply a protective measure to the individual person's subset of individuated personally identifiable information prior to transfer of the data set in a digital/analog signal outside the secure enclave.

Abstract: Disclosed herein are particles and methods of using said particles in assays for detection of biomolecules in a sample. Various methods of the present disclosure utilize particles for biomolecule adsorption. In some aspects, the present disclosure provides methods which utilize multiple particle concentrations to differentially fractionate biological samples. In further aspects, the present disclosure provides methods which utilize low particle concentrations to enhance adsorbed biomolecule diversity.

Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

Abstract: A computing system implements a simulation environment for a graphic design system which creates a plurality of prototype screens that are individually renderable to simulate an application user interface. The computing system displays an initial prototype screen of the plurality of prototype screens, the initial prototype screen including a first set of interactive elements to navigate to a first set of prototype screens, and the computing system loads content associated with each prototype screen of the first set of prototype screens.

Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

Abstract: Disclosed herein is a medical device. The medical device includes two coaxially aligned solenoids and a cannulated armature configured to be received within the two coaxially aligned solenoids.

Abstract: Disclosed herein is a medical device. The medical device includes a blade tube section, a solenoid, and a mechanical arrangement. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The solenoid is offset from a central axis of the blade tube section. The mechanical arrangement is between the inner blade tube and the solenoid.

Abstract: Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a mechanical arrangement. The blade tube section includes an outer blade tube, inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is offset from a central axis of the blade tube section. The mechanical arrangement is between the inner blade tube and the motor.

Abstract: Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a cotch yoke or slotted link mechanism. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is spaced from the blade tube section. The scotch yoke or slotted link mechanism is between the inner blade tube and the motor.

Abstract: Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a lever arm. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is spaced from the blade tube section. The lever arm is between the inner blade tube and the motor.

Abstract: A desk system including desktop, legs, and foot elements is presented. Each leg is rotatably attached at one end to the desktop and attached at another end to one foot element which is also rotatable. The system is disposed in a stowed configuration when legs and foot elements are substantially parallel to the desktop and legs are disposed between and substantially parallel to foot elements. The system is disposed in an upright configuration when legs are substantially perpendicular to the desktop and each leg is substantially perpendicular to one foot element. The system is configured from stowed to upright by separately rotating legs about a minor axis in opposite directions away from one another and by separately rotating foot elements about a major axis in opposite directions toward one another.

Abstract: A desk system including desktop, legs, and foot elements is presented. Each leg is rotatably attached at one end to the desktop and attached at another end to one foot element which is also rotatable. The system is disposed in a stowed configuration when legs and foot elements are substantially parallel to the desktop and legs are disposed between and substantially parallel to foot elements. The system is disposed in an upright configuration when legs are substantially perpendicular to the desktop and each leg is substantially perpendicular to one foot element. The system is configured from stowed to upright by separately rotating legs about a minor axis in opposite directions away from one another and by separately rotating foot elements about a major axis in opposite directions toward one another.

Abstract: A system facilitates secure communication between an authorized user device and two or more servers via two or more channels that are associated with the respective servers. For each communication channel, the system receives a device identifier for the authorized user device and links the device identifiers together via another identifier, thereby allowing the system to recognize that the different device identifiers identify the same authorized user device. The system can identify an unauthorized device masquerading as the authorized user device by determining that a communication from the unauthorized device does not include another identifier linking the two or more device identifiers and/or by determining that a device identifier computed during the registration process is different from a linked identifier.