Patents by Inventor Daniel H. Zimmerman

Daniel H. Zimmerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified HGP-30 heteroconjugates, compositions and methods of use
    Patent number: 6103239
    Abstract: A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of .beta.-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as. for exampleATL YSV HQR IDV KDTKEA LEK IEE EQN KS (SEQ ID NO: 5)The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: August 15, 2000
    Assignee: CEL-SCI Corporation
    Inventors: Daniel H. Zimmerman, Prem S. Sarin
  • Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same
    Patent number: 6096315
    Abstract: The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass of T cells and another of the T cell specific binding ligands is an antigen associated with disease or a causative agent of disease, or epitope thereof. The present invention also relates to vaccines containing the heterofunctional cellular immunological reagents and methods for the use of the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 1, 2000
    Assignee: Cel Sci Corporation
    Inventors: Daniel H. Zimmerman, Donald A. Elliott
  • Modified HGP-30 peptides, conjugates, compositions and methods of use
    Patent number: 6093400
    Abstract: An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: July 25, 2000
    Assignee: Cel Sci Corporation
    Inventors: Daniel H. Zimmerman, Prem S. Sarin
  • Multiple sclerosis associated polypeptide
    Patent number: 5883227
    Abstract: The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas which produce monoclonal antibodies which are specific for the multiple sclerosis-associated antigens. The present invention's use is in diagnosing multiple sclerosis and in routine follow-up monitoring of multiple sclerosis patients as to disease progression or response to therapy.
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: March 16, 1999
    Assignees: Molecullar Rx, Inc., Cell Med, Inc.
    Inventors: Ellis L. Kline, Daniel H. Zimmerman
  • Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same
    Patent number: 5652342
    Abstract: The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass of T cells and another of the T cell specific binding ligands is an antigen associated with disease or a causative agent of disease, or epitope thereof. The present invention also relates to vaccines containing the heterofunctional cellular immunological reagents and methods for the use of the same.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: July 29, 1997
    Assignee: Cel-Sci Corporation
    Inventors: Daniel H. Zimmerman, Donald A. Elliott
  • Assay and treatment for demyelinating diseases such as multiple sclerosis, related hybridomas and monoclonal antibodies
    Patent number: 5645997
    Abstract: The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas which produce monoclonal antibodies which are specific for the multiple sclerosis-associated antigens. The present invention's use is in diagnosing multiple sclerosis and in routine follow-up monitoring of multiple sclerosis patients as to disease progression or response to therapy.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignees: Molecular Rx, Inc., Cell Med, Inc.
    Inventors: Ellis L. Kline, Daniel H. Zimmerman