Patents by Inventor Daniel Hunziker

Daniel Hunziker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methylquinazolinone derivatives
    Patent number: 12116349
    Abstract: The invention provides a novel compound having the general formula (I) or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: October 15, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Daniela Krummenacher, Piergiorgio Francesco Tommaso Pettazzoni, Juergen Wichmann
  • THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF
    Publication number: 20240199581
    Abstract: The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.
    Type: Application
    Filed: December 8, 2023
    Publication date: June 20, 2024
    Applicant: C4 Therapeutics, Inc.
    Inventors: Christopher G. Nasveshuk, Katrina L. Jackson, Yanke Liang, Robert T. Yu, Martin Duplessis, Mark E. Fitzgerald, Victoria Garza, Andrew Charles Good, Morgan Welzel O'Shea, Gesine Kerstin Veits, Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Daniela Krummenacher, Piergiorgio Franceso Tommaso Pettazzoni, Juergen Wichmann
  • METHYLQUINAZOLINONE DERIVATIVES
    Publication number: 20240174621
    Abstract: The invention provides, for example, a novel compound having the general formula (I): or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: November 30, 2023
    Publication date: May 30, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo DOLENTE, David Stephen HEWINGS, Daniel HUNZIKER, Daniela KRUMMENACHER, Piergiorgio Francesco Tommaso PETTAZZONI, Juergen WICHMANN
  • CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES
    Publication number: 20230374014
    Abstract: The invention relates to a compound of formula (I), wherein R1-R3 and A1-A3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: May 18, 2021
    Publication date: November 23, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guido GALLEY, Katrin GROEBKE ZBINDEN, Wolfgang GUBA, Daniel HUNZIKER
  • Benzimidazole derivatives
    Publication number: 20230348398
    Abstract: The invention relates to a compound of formula (I) wherein R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 14, 2021
    Publication date: November 2, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guido GALLEY, Katrin GROEBKE ZBINDEN, Daniel HUNZIKER, Wolfgang GUBA, Stefan BERCHTOLD, Danny KRUMM, Daniela KRUMMENACHER, Manuel HILBERT
  • NEW QUINAZOLINONE DERIVATIVES
    Publication number: 20230331682
    Abstract: The invention relates to a compound of formula (I) Wherein A, L, R1, R2, R3 and R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 16, 2023
    Publication date: October 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Daniela Krummenacher, Piergiorgio Francesco Tommaso Pettazzoni, Fabienne Ricklin, Claus Riemer, Juergen Wichmann
  • NEW ARYL-PYRIDO-PYRIMIDIN-ONE DERIVATIVES
    Publication number: 20230322776
    Abstract: The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 16, 2023
    Publication date: October 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Erik Jung, Piergiorgio Francesco Tommaso Pettazzoni, Fabienne Ricklin, Claus Riemer, Juergen Wichmann
  • MALONITRILE DERIVATIVES
    Publication number: 20230242494
    Abstract: The invention relates to a compound of formula (I) wherein R1-R4 and A1-A2 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: May 18, 2021
    Publication date: August 3, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guillaume DÉCORET, Guido GALLEY, Katrin GROEBKE ZBINDEN, Nicole GROSSMANN, Wolfgang GUBA, Daniel HUNZIKER
  • MALONITRILE DERIVATIVES
    Publication number: 20230242520
    Abstract: The invention relates to a compound of formula (I) wherein R1-R2 are as defined in the description and in the claims The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: May 18, 2021
    Publication date: August 3, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guillaume DÉCORET, Guido GALLEY, Katrin GROEBKE ZBINDEN, Wolfgang GUBA, Daniel HUNZIKER
  • Benzimidazole Derivatives
    Publication number: 20230227411
    Abstract: The invention relates to a compound of formula (I) wherein R1-R3 are as defined in the description and in the claims The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 14, 2021
    Publication date: July 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guido GALLEY, Katrin GROEBKE ZBINDEN, Daniel HUNZIKER, Wolfgang GUBA, Danny KRUMM, Daniela KRUMMENACHER, Manuel HILBERT
  • Indazole Derivatives
    Publication number: 20230192623
    Abstract: The invention relates to a compound of formula (I) wherein R1-R3 are as defined in the description and in the claims The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 14, 2021
    Publication date: June 22, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stefan BERCHTOLD, Guido GALLEY, Katrin GROEBKE ZBINDEN, Wolfgang GUBA, Daniel HUNZIKER, Daniela KRUMMENACHER
  • Biphenyl Derivatives
    Publication number: 20230192631
    Abstract: The invention relates to a compound of formula (I) wherein R1—R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 14, 2021
    Publication date: June 22, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stefan BERCHTOLD, Guido GALLEY, Katrin GROEBKE ZBINDEN, Wolfgang GUBA, Daniel HUNZIKER, Danny KRUMM
  • Bicyclic compounds as ATX inhibitors
    Patent number: 11673888
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 13, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jérôme Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • BRAF DEGRADERS
    Publication number: 20230145336
    Abstract: Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.
    Type: Application
    Filed: December 19, 2022
    Publication date: May 11, 2023
    Applicant: C4 Therapeutics, Inc.
    Inventors: Christopher G. Nasveschuk, Martin Duplessis, Mark E. Fitzgerald, Victoria Garza, Andrew Charles Good, Katrina L. Jackson, Yanke Liang, Moses Moustakim, Morgan Welzel O'Shea, Gesine Kerstin Veits, Jeremy L. Yap, Robert T. Yu, Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Bernd Kuhn, Piergiorgio Francesco Tommaso Pettazzoni, Fabienne Ricklin, Claus Riemer, Juergen Wichmann
  • METHYLQUINAZOLINONE DERIVATIVES
    Publication number: 20220298119
    Abstract: The invention provides a novel compound having the general formula (I) or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 8, 2022
    Publication date: September 22, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo DOLENTE, David Stephen HEWINGS, Daniel HUNZIKER, Daniela KRUMMENACHER, Piergiorgio Francesco Tommaso PETTAZZONI, Juergen WICHMANN
  • BRAF INHIBITORS AS PARADOX BREAKERS
    Publication number: 20220298145
    Abstract: The invention provides a novel compound having the general formula (I) wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 8, 2022
    Publication date: September 22, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Cosimo DOLENTE, David Stephen HEWINGS, Daniel HUNZIKER, Daniela KRUMMENACHER, Piergiorgio Francesco Tommaso PETTAZZONI, Juergen WICHMANN
  • Phenoxymethyl derivatives
    Patent number: 11352330
    Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 7, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Holger Kuehne, Thomas Luebbers, Rainer E. Martin, Patrizio Mattei, Werner Neidhart, Hans Richter, Markus Rudolph, Emmanuel Pinard
  • Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Patent number: 11098048
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 24, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • Heterocyclic compounds useful as dual ATX/CA inhibitors
    Patent number: 11059794
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: July 13, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Jérôme Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio, Justin Gomme
  • Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
    Patent number: 10913745
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: February 9, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jerome Hert, Daniel Hunziker, Patrizio Mattei, Harald Mauser, Guozhi Tang, Lisha Wang