Patents by Inventor Daniel J. McCormick
Daniel J. McCormick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10774957Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.Type: GrantFiled: July 30, 2018Date of Patent: September 15, 2020Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Jonathan L. Belanger, Sylvain Cormier, Steven D. Trudeau, Paul Keenan, Daniel J. McCormick
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Patent number: 10232287Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.Type: GrantFiled: March 4, 2013Date of Patent: March 19, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Kurt D. Joudrey, Steven D. Trudeau, Paul Keenan, Joseph A. Luongo, Daniel J. McCormick, Eugene Berthiaume
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Publication number: 20180335170Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.Type: ApplicationFiled: July 30, 2018Publication date: November 22, 2018Inventors: Jonathan L. Belanger, Sylvain Cormier, Steven D. Trudeau, Paul Keenan, Daniel J. McCormick
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Patent number: 10060560Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.Type: GrantFiled: June 25, 2013Date of Patent: August 28, 2018Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Jonathan L. Belanger, Sylvain Cormier, Steven D. Trudeau, Paul Keenan, Daniel J. McCormick
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Publication number: 20150211663Abstract: Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket. The coupling body has a threaded bore at one end, a tapered cavity, a narrow bore and a fluid channel. The compression screw has an axial bore to receive a tube and a threaded outer surface in engagement with the threaded bore of the coupling body. The compression member is disposed in the tapered cavity and has an axial opening to pass the tube and a tapered surface to engage a surface of the tapered cavity. The gasket is disposed in the narrow bore and has one surface in contact with the first internal surface and has a parallel surface to receive an end face of the tube. Mobile phase flows along a path that includes the tube, an opening in the gasket and the fluid channel.Type: ApplicationFiled: June 25, 2013Publication date: July 30, 2015Inventors: Jonathan L. Belanger, Sylvain Cormier, Steven D. Trudeau, Paul Keenan, Daniel J. McCormick
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Publication number: 20150048015Abstract: An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port.Type: ApplicationFiled: March 4, 2013Publication date: February 19, 2015Inventors: Kurt D. Joudrey, Trudeau D. Steven, Paul Keenan, Joseph A. Luongo, Daniel J. McCormick, Eugene Berthiaume
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Publication number: 20140066367Abstract: This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.Type: ApplicationFiled: March 12, 2013Publication date: March 6, 2014Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Horng H. Chen, John C. Burnett, JR., Daniel J. McCormick
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Publication number: 20130210740Abstract: Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L?, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.Type: ApplicationFiled: August 21, 2012Publication date: August 15, 2013Inventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 8241013Abstract: Embodiments of the present invention are directed to devices and methods for propelling fluids that feature at least one first pump assembly having a primary pump, an accumulator pump, drive means, valve means and control means. The valve means moves between the first position and the second position as the accumulator pump and primary pump alternate between a loading movement and a pump movement. The control means is in signal communication with the accumulator pump, the primary pump and the valve means. The control means issues signal command to the accumulator pump to assume the loading movement and the pump movement and the primary pump to assume the loading movement and pump movement in coordination with the movement of the valve means such that fluids are propelled from the first outlet.Type: GrantFiled: October 24, 2006Date of Patent: August 14, 2012Assignee: Waters Technologies CorporationInventors: Mark W. Moeller, Daniel J. McCormick, Joseph A. Luongo
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Publication number: 20120178904Abstract: Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.Type: ApplicationFiled: July 7, 2011Publication date: July 12, 2012Inventors: Elliot RICHELSON, Daniel J. McCORMICK, Yuan-Ping PANG, Kenneth S. PHILLIPS
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Publication number: 20120108519Abstract: Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L?, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.Type: ApplicationFiled: December 13, 2011Publication date: May 3, 2012Inventors: ELLIOTT RICHELSON, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Publication number: 20110263507Abstract: Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.Type: ApplicationFiled: July 7, 2011Publication date: October 27, 2011Inventors: ELLIOTT RICHELSON, Daniel J. McCormick, Yuan-Ping Pang, Kenneth S. Phillips
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Publication number: 20110183885Abstract: Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L?, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.Type: ApplicationFiled: March 31, 2011Publication date: July 28, 2011Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 7955059Abstract: In various embodiments a fluid control device suitable for high pressure analytical instruments includes a housing having an interior surface with an end wall. The interior surface defines a chamber. A valve assembly disposed in the chamber controls the flow of fluid through the chamber. An end cap is disposed in the housing opposite the end wall to enclose the chamber. The end wall and end cap each have an opening to pass a fluid to the chamber or to remove a fluid from the chamber. The housing and end cap each has an abutment surface to receive the other abutment surface. At least one of the abutment surfaces has a plastic seal coating. A means of compression, such as a compression housing and compression sleeve, is included to engage the end cap to deform the plastic seal coating between the abutment surfaces and thereby seal the chamber.Type: GrantFiled: March 2, 2005Date of Patent: June 7, 2011Assignee: Waters Technologies CorporationInventors: Theodore D. Ciolkosz, Peter Kirby, Mark W. Moeller, Russell Keene, Daniel J. McCormick, Charles Murphy, Joseph A. Luongo, David R. Friswell, Theodore Dourdeville
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Patent number: 7951597Abstract: The present invention is a pressurized fluid sample injector system consisting of a sample needle, multiport valve, sample loop, metering syringe and a pressure assist pump. The speed of sample transport into the sample loop is increased by pressurizing the fluid in the system and metering the sample into the sample loop. The elevated system pressure allows the fluids to be moved faster than the vapor pressure would normally allow in a system at ambient pressure.Type: GrantFiled: September 15, 2006Date of Patent: May 31, 2011Assignee: Waters Technologies CorporationInventors: James E. Usowicz, Theodore C. Ciolkosz, Russell Keene, Daniel J. McCormick
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Publication number: 20100173849Abstract: Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L?, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.Type: ApplicationFiled: January 4, 2010Publication date: July 8, 2010Inventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Publication number: 20100024906Abstract: Embodiments of the present invention are directed to devices and methods for propelling fluids that feature at least one first pump assembly having a primary pump, an accumulator pump, drive means, valve means and control means. The valve means moves between the first position and the second position as the accumulator pump and primary pump alternate between a loading movement and a pump movement. The control means is in signal communication with the accumulator pump, the primary pump and the valve means. The control means issues signal command to the accumulator pump to assume the loading movement and the pump movement and the primary pump to assume the loading movement and pump movement in coordination with the movement of the valve means such that fluids are propelled from the first outlet.Type: ApplicationFiled: October 24, 2006Publication date: February 4, 2010Applicant: WATERS INVESTMENTS LIMITEDInventors: Mark W. Moeller, Daniel J. McCormick, Joseph A. Luongo
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Patent number: 7642231Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: GrantFiled: June 14, 2006Date of Patent: January 5, 2010Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Publication number: 20090062212Abstract: Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.Type: ApplicationFiled: May 7, 2007Publication date: March 5, 2009Inventors: Elliott Richelson, Daniel J. McCormick, Yuan-Ping Pang, Kenneth S. Phillips
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Patent number: 7279149Abstract: An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.Type: GrantFiled: February 10, 2004Date of Patent: October 9, 2007Assignee: Mayo Foundation for Medical Education and ResearchInventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack, Daniel J. McCormick, Abdul H. Fauq