Patents by Inventor Daniel J. McCormick
Daniel J. McCormick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7098307Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: GrantFiled: July 8, 2005Date of Patent: August 29, 2006Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 6921805Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: GrantFiled: June 1, 2004Date of Patent: July 26, 2005Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Publication number: 20040224889Abstract: The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal.Type: ApplicationFiled: March 12, 2004Publication date: November 11, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Beth Marie Tyler, Daniel J. McCormick, Bernadette Marie Cusack, Clark V. Hoshall, Christopher Lee Douglas, Karen Jansen
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Publication number: 20040220108Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: ApplicationFiled: June 1, 2004Publication date: November 4, 2004Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 6765099Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: GrantFiled: October 4, 2002Date of Patent: July 20, 2004Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq
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Patent number: 6743627Abstract: The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.Type: GrantFiled: January 30, 1998Date of Patent: June 1, 2004Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Beth Marie Tyler, Daniel J. McCormick, Bernadette Marie Cusack, Clark V. Hoshall, Christopher Lee Douglas, Karen Jansen
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Publication number: 20030166505Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: ApplicationFiled: October 4, 2002Publication date: September 4, 2003Applicant: Mayo Foundation for Medical Education and Research, a Minnesota corporationInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 6472209Abstract: The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.Type: GrantFiled: October 17, 1997Date of Patent: October 29, 2002Assignee: Mayo Foundation for Medical Education and ResearchInventors: Elliott Richelson, Beth Marie Tyler, Daniel J. McCormick, Bernadette Marie Cusack, Clark V. Hoshall, Christopher Lee Douglas, Karen Jansen
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Publication number: 20010027174Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: ApplicationFiled: January 5, 2001Publication date: October 4, 2001Applicant: Mayo Foundation for Medical Education and Research Minnesota corporationInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 6214790Abstract: The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.Type: GrantFiled: April 9, 1999Date of Patent: April 10, 2001Assignee: Mayo Foundation for Medical Education And ResearchInventors: Elliott Richelson, Bernadette Marie Cusack, Yuan-Ping Pang, Daniel J. McCormick, Abdul Fauq, Beth Marie Tyler, Mona Boules
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Patent number: 5196513Type: GrantFiled: July 25, 1991Date of Patent: March 23, 1993Assignee: Mayo Foundation for Medical Education and ResearchInventors: Robert J. Ryan, Daniel J. McCormick, John C. Morris
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Patent number: 4973578Abstract: Synthetic peptides corresponding to .alpha.-subunit of human glycoprotein hormone amino acid regions .alpha.31-45, .alpha.21-35, .alpha.26-46 and .alpha.81-92; were found to inhibit binding of 125.sub.I-bTSH to human thyroid. Peptides corresponding to regions .alpha.26-46 and .alpha.31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.Type: GrantFiled: March 17, 1988Date of Patent: November 27, 1990Assignee: Mayo Foundation for Medical Education and ResearchInventors: Robert J. Ryan, Daniel J. McCormick, John C. Morris, M. Cristine Charlesworth
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Patent number: 4573239Abstract: A hinge has a pair of leaves, one of which has a spaced pair of knuckles and the other has a central knuckle disposed therebetween. Disposed in the single knuckle are a pair of tubular bushing inserts received in opposite ends of its passage and having radial flanges disposed between the adjacent knuckles. The two knuckle hinge leaf is engaged with a pair of hinge pin elements extending inwardly from the opposite end of the leaf so as to prevent relative rotation therebetween, while the hinge pin elements extend into and are freely rotatable in the inserts. In the method of assembly, the bearing inserts are placed in the single knuckle leaf, and the two knuckle leaf is then aligned therewith and the hinge pin elements are inserted and engaged with the two knuckle leaf to prevent relative rotation therebetween.Type: GrantFiled: August 17, 1984Date of Patent: March 4, 1986Assignee: The Stanley WorksInventors: Richard L. Valenti, Daniel J. McCormick