Patents by Inventor Daniel J. SIEGWART

Daniel J. SIEGWART has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220233460
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: April 1, 2022
    Publication date: July 28, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220133637
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 5, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Compositions and methods for organ specific delivery of nucleic acids
    Patent number: 11304911
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: April 19, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Qiang Cheng, Tuo Wei, Daniel J. Siegwart
  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20220071916
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: March 4, 2021
    Publication date: March 10, 2022
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • Lipocationic dendrimers and uses thereof
    Patent number: 11247968
    Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: February 15, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Daniel J. Siegwart, Kejin Zhou
  • Compositions and methods for organ specific delivery of nucleic acids
    Patent number: 11229609
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: January 25, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Qiang Cheng, Tuo Wei, Daniel J. Siegwart
  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20210401762
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: September 13, 2021
    Publication date: December 30, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • CATIONIC SULFONAMIDE AMINO LIPIDS AND AMPHIPHILIC ZWITTERIONIC AMINO LIPIDS
    Publication number: 20210395192
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Application
    Filed: August 11, 2021
    Publication date: December 23, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Jason B. MILLER
  • COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS
    Publication number: 20210259980
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Application
    Filed: March 4, 2021
    Publication date: August 26, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Qiang CHENG, Tuo WEI, Daniel J. SIEGWART
  • LIPID NANOPARTICLE COMPOSITIONS FOR DELIVERY OF MRNA AND LONG NUCLEIC ACIDS
    Publication number: 20210121411
    Abstract: In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 29, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Qiang CHENG
  • COMPOSITIONS FOR THE DELIVERY OF tRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH
    Publication number: 20210023120
    Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.
    Type: Application
    Filed: October 6, 2020
    Publication date: January 28, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Philip J. Thomas, Arthur E. Johnson, Michael J. Torres, Jason B. Miller
  • CATIONIC SULFONAMIDE AMINO LIPIDS AND AMPHIPHILIC ZWITTERIONIC AMINO LIPIDS
    Publication number: 20200140378
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 7, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Jason B. MILLER
  • Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
    Patent number: 10562849
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: February 18, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Jason B. Miller
  • COMPOSITIONS FOR THE DELIVERY OF TRNA AS NANOPARTICLES AND METHODS OF USE THEREWITH
    Publication number: 20170354672
    Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.
    Type: Application
    Filed: May 16, 2017
    Publication date: December 14, 2017
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Philip J. Thomas, Arthur E. Johnson, Michael J. Torres, Jason B. Miller
  • CATIONIC SULFONAMIDE AMINO LIPIDS AND AMPHIPHILIC ZWITTERIONIC AMINO LIPIDS
    Publication number: 20170349543
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Application
    Filed: May 16, 2017
    Publication date: December 7, 2017
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Jason B. Miller
  • Lipocationic polymers and uses thereof
    Patent number: 9801944
    Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 31, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Jing Hao, Kejin Zhou, Jason Miller, Petra Kos, Lian Xue
  • LIPOCATIONIC DENDRIMERS AND USES THEREOF
    Publication number: 20170121279
    Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
    Type: Application
    Filed: September 14, 2016
    Publication date: May 4, 2017
    Inventors: Daniel J. SIEGWART, Kejin ZHOU
  • LIPOCATIONIC POLYMERS AND USES THEREOF
    Publication number: 20170100482
    Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
    Type: Application
    Filed: September 9, 2016
    Publication date: April 13, 2017
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Jing HAO, Kejin ZHOU, Jason MILLER, Petra KOS, Lian XUE
  • Lipocationic polymers and uses thereof
    Patent number: 9517270
    Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: December 13, 2016
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Jing Hao, Kejin Zhou, Jason Miller, Petra Kos, Lian Xue
  • LIPOCATIONIC POLYMERS AND USES THEREOF
    Publication number: 20160220681
    Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
    Type: Application
    Filed: December 8, 2015
    Publication date: August 4, 2016
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Daniel J. SIEGWART, Jing HAO, Kejin ZHOU, Jason MILLER, Petra KOS, Lian XUE