Abstract: Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.

Abstract: Examples described herein relate to transitioning a playback session between portable playback devices such as “smart” headphones, earbuds, and handheld speakers with playback devices of a zone-based media playback system. Exemplary techniques facilitate continuity of playback when transitioning between locations (e.g., from at home to on-the-go or vice versa) or between listening paradigms (e.g., personal or out-loud playback of audio content). An example implementation includes detecting a swap trigger, determining the source playback device(s) and target playback device(s), and performing a playback session swap between the source playback device(s) and target playback device(s).

Abstract: The present invention relates to novel compounds and their use as fragrance materials.

Abstract: Disclosed are floating micro-aeration unit (FMU) devices, systems and methods for biological sulfide removal from water/wastewater bodies and streams. In some aspects, a system includes a manifold structure including one or more opening to flow air out of an interior of the manifold structure; one or more support structures connected to the manifold structure, in which the one or more support structures are floatable on a surface of a fluid that includes water or a wastewater; and an air source that flows air to the manifold structure, such that the manifold structure supplies the air containing a predetermined amount of oxygen (e.g., less than 0.1 mg/L of oxygen) to oxidize sulfide of the fluid.

Abstract: An arrow fletching apparatus with tapered body for use in the sport of archery is provided. The fletching apparatus is used in place of a fletching jig and glue conventionally used to fix fletching to an arrow shaft. The tapered body provides for an overall reduced weight of the apparatus.

Abstract: A system for controlling a throttle signal, as well as methods of assembling the same, is provided. Controlling the throttle signal includes activating a supply of power to an electronic control unit (ECU). A first throttle signal associated with a throttle position signal of a vehicle throttle is communicated. An initial gear state of the vehicle is determined. Based on the initial gear state of the vehicle, a modified throttle signal to the ECU is communicated in response to receiving a command signal. Based on determining a change in the gear state of the vehicle, terminating the communication of the modified throttle signal. A second throttle signal that is associated with a second throttle position signal of the vehicle throttle is communicated.

Abstract: Provided herein are methods and compositions for the detection of in-frame deletion germline mutations in the CALR gene. Also provided are methods for determining the prognosis of myeloproliferative diseases and the likelihood of developing somatic mutations in genes involved in the JAK-STAT pathway.

Abstract: Systems and methods for increasing the safety of vehicle platooning systems are described. In one aspect, a determination is made as to how many trailers are connected to a tractor, and whether those trailers and any dollies are equipped with an Anti-Lock Braking System. For example, an average rate of messages that indicate an ABS system is operating correctly may be determined. Also, an amount of messages received within a certain time interval may be determined. Based on whether the average rate is above a threshold amount and whether an amount of messages were received within one or more time intervals a determination may be made as to whether an adverse action occurs such as losing the authority to cause a trailer to brake fully and/or dissolve a platoon.

Abstract: Systems and methods for increasing the safety of vehicle platooning systems are described. In one aspect, a determination is made as to how many trailers are connected to a tractor, and whether those trailers and any dollies are equipped with an Anti-Lock Braking System. For example, multiple processes for determining whether an Anti-Lock Braking System is operating correctly may be employed to prevent false positives and false negatives. Such processes may determine rates of messages received from Anti-Lock Braking System units, types of messages received from Anti-Lock Braking System units, and/or amounts of types of messages received from Anti-Lock Braking System units.

Abstract: Systems and methods for increasing the safety of vehicle platooning systems are described. In one aspect, a determination is made as to how many trailers are connected to a tractor, and whether those trailers and any dollies are equipped with an Anti-Lock Braking System. For example, multiple processes for determining whether an Anti-Lock Braking System is operating correctly may be employed to prevent false positives and false negatives. Such processes may determine rates of messages received from Anti-Lock Braking System units, types of messages received from Anti-Lock Braking System units, and/or amounts of types of messages received from Anti-Lock Braking System units.

Abstract: An arrow fletching apparatus with tapered body for use in the sport of archery is provided. The fletching apparatus is used in place of a fletching jig and glue conventionally used to fix fletching to an arrow shaft. The tapered body provides for an overall reduced weight of the apparatus.

Abstract: The present invention relates to novel compounds and their use as fragrance materials.

Abstract: Provided herein are methods and compositions for the detection of in-frame deletion germline mutations in the CALR gene. Also provided are methods for determining the prognosis of myeloproliferative diseases and the likelihood of developing somatic mutations in genes involved in the JAK-STAT pathway.

Abstract: The invention relates to compounds, compositions, and methods that can inhibit the biosynthesis of mycotoxins.

Abstract: A dashboard component assembly for a vehicle, including: a cover-panel; a main body and an auxiliary body, the auxiliary body being retained on the main body so as to be movable in at least one dimension relative to the main body prior to installation of the cover-panel, the cover-panel is configured to cover at least a portion of each of the main body and the auxiliary body; a primary datum included by one of the cover-panel or the main body; a primary datum retainer included by the other of the cover-panel or the main body, the primary datum is configured to engage at least one primary datum retainer to cause a predetermined alignment of the cover-panel with regard to the main body; a secondary datum included by one of the cover-panel or the auxiliary body; a secondary datum receiver comprised by the other of the cover-panel or the auxiliary body.

Abstract: The present invention provides for single-molecule profiling of combinatorial protein modifications and single-molecule profiling of combinatorial protein modifications combined with single-molecule sequencing of protein/nucleic acids complexes. High-throughput single-molecule imaging was applied to decode combinatorial modifications on millions of individual nucleosomes from pluripotent stem cells and lineage-committed cells. Applicants identified bivalent nucleosomes with concomitant repressive and activating marks, as well as other combinatorial modification states whose prevalence varies with developmental potency. Applying genetic and chemical perturbations of chromatin enzymes show a preferential affect on nucleosomes harboring specific modification states. The present invention also combines this proteomic platform with single-molecule DNA sequencing technology to simultaneously determine the modification states and genomic positions of individual nucleosomes.

Abstract: A sobriety ignition interlock system including an engine control device and a method for managing available vehicle engine power using the sobriety ignition interlock system. The engine control device includes an engine control processor (ECP) that is electronically connected in between an engine control unit (ECU), an engine sensor assembly, and a sobriety processor. The sobriety processor determines a sobriety level of a vehicle driver and sends a corresponding sobriety signal to the ECP. The ECP intercepts an engine signal transmitted from the engine sensor assembly to the ECU and manipulates the engine signal according to the sobriety signal, in order to manage the available power of the vehicle engine.

Abstract: A fiber ring resonator having a relatively long loop of standard single-mode fiber with a short nanofiber segment. The evanescent mode of the nanofiber segment allows the cavity-enhanced field to interact with atoms in close proximity to the nanofiber surface.

Abstract: A bulkhead assembly for use with a concrete form and a first reinforcement bar is disclosed. The concrete form may have first and second spaced form sides; and the first reinforcement bar may be disposed between and may extend longitudinally of the spaced form sides. The bulkhead assembly may have a first pair of channel assemblies, each including a channel member and an elastomeric member. The elastomeric member may be positioned longitudinally in the channel member, with a portion of the elastomeric member extending outward transversely from the channel member. The portion may include an outer end that extends longitudinally of the channel member. The channel assemblies may be positioned on opposite sides of the reinforcement bar, with the elastomeric member outer ends facing one another and contacting the reinforcement bar, thereby inhibiting uncured concrete from passing between the channel assemblies when uncured concrete is poured into the concrete form.