Abstract: Provided herein are methods and compositions for the detection of in-frame deletion germline mutations in the CALR gene. Also provided are methods for determining the prognosis of myeloproliferative diseases and the likelihood of developing somatic mutations in genes involved in the JAK-STAT pathway.

Abstract: An arrow fletching apparatus for use in the sport of archery is provided. The fletching apparatus is used in place of conventional fletching and provides for adjustability and easy replacement of the apparatus itself or individual fletches in the field. The fletching apparatus comprises a body and a plurality of fletches. The body is kept in place on the arrow shaft by a friction fit and the fletches are likewise kept in place within a slot on the body by a friction fit.

Abstract: A vacuum system for removing rubbish generated during fastening operations is provided. The vacuum system includes a fastening tool for driving the fastener, a suction nozzle attached to the fastening tool and a vacuum source in fluid communication with the suction nozzle. The vacuum system also includes a sensor to detect the position of the fastening tool and a vacuum valve actuator to selectively open or close a vacuum valve to provide vacuum to the suction nozzle according to the position of the fastening tool.

Abstract: Provided are a power management system and method. At least one frame module includes at least one bay and a plurality of first connectors at a rear portion of the at least one bay and at least one power conversion unit positioned in the at least one bay. The at least one power conversion unit includes a plurality of second connectors. Each second connector is removably coupled to a first connector of the plurality of first connectors. The first and second connectors include a combination of high power, cooling, and control connectors.

Abstract: An Apparatus, method and system that blocks vehicle engine starting and reduces engine power when a driver's blood alcohol content is above a pre-set limit. The invention receives an electronic signal from at least one electronically controlled engine sensor and modifies the at least one signal such that the electronically controlled engine is not allowed to start or engine power is reduced, as relating to driver intoxication.

Abstract: A conventional containment vessel is retrofitted into a complete integral tank double-hull cargo containment vessel that includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: A vacuum system for removing rubbish generated during fastening operations is provided. The vacuum system includes a fastening tool for driving the fastener, a suction nozzle attached to the fastening tool and a vacuum source in fluid communication with the suction nozzle. The vacuum system also includes a sensor to detect the position of the fastening tool and a vacuum valve actuator to selectively open or close a vacuum valve to provide vacuum to the suction nozzle according to the position of the fastening tool.

Abstract: An apparatus, such as but not necessarily limited to a safe, is contemplated. The apparatus may be configured to secure a sorter, bill validator or other delivery mechanism separately from a storage area in order to permit removal of the delivery mechanism without compromising security of the storage area.

Abstract: An apparatus, such as but not necessarily limited to a safe, is contemplated. The apparatus may be configured to secure a sorter, bill validator or other delivery mechanism separately from a storage area in order to permit removal of the delivery mechanism without compromising security of the storage area.

Abstract: A validating system is contemplated to facilitate interchangeable use of safes configured to electronically validate paper currency or other types of currency. The validating system may allow currency delivery entities to exchange safes rather than having to remove a cassette or otherwise access contents stored within the safe.

Abstract: A conventional containment vessel is retrofitted into a complete integral tank double-hull cargo containment vessel that includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: A complete double-hull cargo containment vessel includes a primary hull and a secondary hull disposed within the primary hull. The primary hull includes a topside deck structural member. The secondary hull includes an interior cargo containment tank. The secondary hull includes a topside structural member configured to seal the cargo containment tank. The primary hull is configured to serve as a first boundary between an operating environment of the vessel and the cargo. The secondary hull is configured to serve as a second boundary between the operating environment of the vessel and the cargo. The topside deck member of the primary hull and the topside structural member of the secondary hull are configured to provide a double-hull on the topside of the cargo containment tank.

Abstract: Provided are a power management system and method. At least one frame module includes at least one bay and a plurality of first connectors at a rear portion of the at least one bay and at least one power conversion unit positioned in the at least one bay. The at least one power conversion unit includes a plurality of second connectors. Each second connector is removably coupled to a first connector of the plurality of first connectors. The first and second connectors include a combination of high power, cooling, and control connectors.

Abstract: A mixed-signal network for generating distributed electrical pulses includes a control device and one or more networked mixed-signal devices. The control device generates digital and analog outputs that are directly connected to, or daisy-chained between, the networked mixed-signal devices. Each mixed-signal device responds under certain input conditions by generating one or more electrical pulses with characteristics controllable by the control device.

Abstract: A single-use device that produces a readily interpretable, visual presentation of biomaterial, enabling single parameter and multi-parameter characterizing of said biomaterial by means of visual inspection, particularly for immunophenotyping. In one embodiment, the device uses antibody coated microspheres which are adapted to bind to specific types of cells. An arrangement of uniquely molded components, which may be plastic or other suitable material, are assembled so as to provide a sequential procedure capable of incubating a suspension comprised of antibody coated microspheres, biomaterial, and liquid suspension agents. Following incubation, the invention further removes liquids from said suspension, and provides for rinsing the incubated retentate and for removing said rinsing liquids from the incubated retentate. The invention further provides for affixing the incubated retentate onto a standard glass microscope slide to enable phenotyping of incubated biomaterial (e.g.

Abstract: The invention relates to a hydraulic pump or hydraulic motor having an orbiting cardan shaft. The hydraulic pump or motor includes a housing having an end cover and a port plate. The cardan shaft is mounted in the housing and extends through the port plate. A rotation speed sensor is fixed to the port plate and includes a sensor probe obtaining its signal from the orbiting cardan shaft. A piston may be in contact with the cardan shaft and moving forward and back due to the orbital motion of the cardan shaft. The sensor probe then obtains its signal from the movement of the piston.

Abstract: A system facilitates the purchase of telecommunication services from a variety of sellers. The system stores a set of responses to purchase requests for telecommunication services associated with a plurality of service providers, each response reflecting at least one telecommunication service offering associated with one of the service providers and a related cost for the telecommunication service offering. The system establishes a session for considering the purchase of telecommunication services. A purchase request is input, including information indicating a requested telecommunication service. The system accesses the stored set of responses to purchase requests for at least one response reflecting at least one telecommunication service offering capable of satisfying the requested telecommunication service, and permits a requester to accept the response during the session.

Abstract: The present subject matter relates to receivers for concentrating photovoltaic systems and methods for fabricating such receivers. A receiver for a concentrating photovoltaic system can comprise a substrate, a plurality of electrical contact pads located on a first surface of the substrate, and a plurality of photovoltaic cells each having plurality of electrically conductive traces that are each electrically coupled to one of the electrical contact pads. In some embodiments, all of the conductive traces can be located on the back surface of the photovoltaic cells for conduction of electric current generated by the photovoltaic cells when illuminated. Alternatively, conductive traces can further be located on a front surface of the photovoltaic cells and can be electrically coupled to corresponding contact pads by electrical connectors. Regardless of the specific arrangement, the receivers can be fabricated using industry standard soldering techniques often used in the electronics industry.

Abstract: The present invention is directed to the diastereoisomeric mixture and the individual isomeric components of the formula: