Abstract: A tension compensation system for a robotically controlled medical device can include an instrument controller configured to operatively connect to a robotically controlled medical device to provide tension to one or more actuation cables of the robotically controlled medical device. The system can include an instrument control module configured to control the instrument controller to provide a compensation tension to at least one actuation cable of the one or more actuation cables to compensate for elongation of the at least one actuation cable of the one or more actuation cables based on actuation data associated with the at least one actuation cable of the one or more actuation cables.

Abstract: An end effector for a minimally invasive medical device can include a base configured to attach to a distal end of a shaft, and a disposable distal portion configured to removably attach to the base to be disposed of after use.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: Implementations described herein relate to providing device messages in image compilations based on user content. A computer-implemented method includes determining that a playback mode is entered on a device to display one or more image compilations, each image compilation including images for successive display. Message criteria are obtained for device messages, each device message indicating a device function associated with images of the image compilations or of a user image library. A device message is selected based on associated message criteria. An image is identified in the user image library, the image being in the image compilations, depicts a type of image feature in the image compilations, and/or has characteristic(s) modifiable by the device function. The device message is displayed during image compilation playback and includes the identified image and a message control option. In response to user selection of the message control option, the device function is initiated.

Abstract: A force transmission system for a robotically controlled medical device includes a pushing actuator adapted and configured to be pushed distally by a robotic instrument controller, a pivot, and a reverse linkage rotatable about the pivot. The reverse linkage includes a first portion extending between the pivot and the pushing actuator, and operably engaged with the pushing actuator, a second portion extending from the pivot away from the first portion, adapted to engage a control wire of the robotically controlled medical device and pull the control wire proximally in response to distal movement of the pushing actuator, and a distal surface of the second portion having an arcuate surface adapted maintain an axial position of the control wire throughout a range of motion thereof.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: The present disclosure describes a network switch design that includes a vertical switch circuit board that is mounted parallel to the front panel of the network switch. The vertical circuit board supports switch chip(s) to process and forward packets and pluggable module connectors to receive pluggable optics modules that provide connections to other network switches. The pluggable module connectors are horizontally oriented to facilitate routing of electrical signal traces. The arrangement of the circuit board, switch chip(s) and pluggable module connectors achieves reduced lengths for the electrical signal traces that connect the switch chip(s) to the pluggable module connectors. The design improves cooling by providing separate airflow regions between the switch chip heatsink(s) and the optics modules.

Abstract: The invention relates to integrated DNA and RNA library preparations and methods of making and uses thereof, wherein the DNA molecules are labelled with a tag identifying the molecule as being a DNA molecule and the RNA molecules are labelled with a tag identifying the molecule as being a RNA molecule. The methods do not require physical separation of DNA and RNA. The methods output two separate libraries from DNA and RNA, respectively, which helps flexible manipulation on downstream sequencing platforms. The application also claims the DNA library and the cDNA library produced by the method and the DNA tag and the RNA tag used in the method.

Abstract: Provided herein are methods for detecting a RAS pathway mutations in a subject. The methods include obtaining a biological sample from the subject, isolating nucleic acids from the biological sample, and analyzing the expression level of extracellular RNAs in the nucleic acids, wherein a differential expression level of the extracellular RNAs compared to a control sample indicates that the subject has a RAS pathway mutation.

Abstract: An end effector for a minimally invasive medical device can include a base configured to attach to a distal end of a shaft, and a disposable distal portion configured to removably attach to the base to be disposed of after use.

Abstract: The present disclosure describes a network switch design that includes a vertical switch circuit board that is mounted parallel to the front panel of the network switch. The vertical circuit board supports switch chip(s) to process and forward packets and pluggable module connectors to receive pluggable optics modules that provide connections to other network switches. The pluggable module connectors are horizontally oriented to facilitate routing of electrical signal traces. The arrangement of the circuit board, switch chip(s) and pluggable module connectors achieves reduced lengths for the electrical signal traces that connect the switch chip(s) to the pluggable module connectors. The design improves cooling by providing separate airflow regions between the switch chip heatsink(s) and the optics modules.

Abstract: A force transmission system for a robotically controlled medical device can include a pushing actuator configured to be pushed by a robotic instrument controller and a wire. The wire can include a first end attached to an end of the pushing actuator to be pushed distally by the pushing actuator, and a second end attached to a distal location of the medical device. The system can include a reverse motion device that can be interfaced with the wire between the first end and the second end. The reverse motion device can be configured to cause a proximal pulling action on the second end in response to pushing of the first end distally by the pushing actuator or other actuation by the pushing actuator. The reverse motion device can be configured to maintain a point of contact with the wire in the same spatial location to prevent wire motion due to actuation.

Abstract: The present application discloses a shoe heating apparatus including a base with a heating unit, and a thermally insulative body, wherein the bottom of the base is shaped as bottom of a foot such that it fits with a shoe sole.

Abstract: Example embodiments relate to reducing auto-exposure latency. An example embodiment includes a method of reducing auto-exposure latency. The method includes determining, by a processor, a first setting of an exposure parameter for a first frame to be captured by an image sensor. The first setting of the exposure parameter is determined based at least in part on characteristics of a previous frame captured by the image sensor. The first setting of the exposure parameter is determined during a first frame period associated with capturing the first frame. The method also includes initiating, by the processor, a first frame exposure operation based on the first setting of the exposure parameter. During the first frame exposure operation, the image sensor captures the first frame during the first frame period.

Abstract: The present application discloses footwear comprising a body structure in which at least upper is made of one continuous folded composite material comprised of layered sheets of material.

Abstract: The present invention relates to a plant-based COVID-19 variant recombinant spike protein expression vector, and a recombinant protein using the expression vector, wherein a plant expression system is used such that the recombinant protein does not have the disadvantages of animal-derived recombinant proteins and exhibits an excellent SARS coronavirus 2 prevention and treatment effect, and thus can be effectively utilized as a safe composition for preventing and treating COVID-19.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: Embodiments of the invention are directed to a method for aligning multiple sequences that models a sequence as a series of bases, wherein adjacent bases are connected through flexible spaces with variable lengths that represent extra spaces between adjacent bases. The method begins with creating an array of floating-point variables that represent spaces for bases within sequences. The method iteratively converges to the optimum set of spaces by gradient descent. In a non-limiting example of the method, the gradients of a space can be obtained by calculating a cost value used to increment or decrement the corresponding space by an integer amount. After each iteration, the spaces are updated by summing the calculated gradients scaled by a change rate, and the sequences are updated by adding or removing gaps between each base according to the quantized spaces. The final sequences become the solution to the multiple sequence alignment task.

Abstract: A steerable overtube assembly for a robotic surgical system can include a steerable shaft having one or more instrument channel and a control hub configured to mount to the steerable shaft. The assembly can also include a manual actuator extending from the control hub and configured to allow the steerable shaft to be manually steered by a user's hand, and a robotic actuator housed by and/or extending from the control hub configured to connect to a robotic driver to allow robotic steering of the steerable shaft.

Abstract: A method for providing an offer to a potential recipient is provided. The method includes obtaining first information, such as demographic information and/or shopping history information, that relates to the potential recipient; assigning a respective value to each of a plurality of first parameters based on the first information; assigning a respective value to each of a plurality of second parameters based on second information that relates to the offer; determining a composite score based on the assigned first parameter values and the assigned second parameter values; and determining, based on the composite score, whether to provide the offer to the potential recipient.