Abstract: An optical encoder comprises an emitter; a receiver; a reflector; and a code carrier, wherein the emitter emits electromagnetic radiation along an emission axis in the direction of the reflector and the reflector deflects the electromagnetic radiation along a reception axis in the direction of the receiver. The code carrier is movably supported and has a sequence of code sections to interrupt or to give way for the emitted electromagnetic radiation to impinge on the detector in dependence on the position of the code carrier, wherein the emission axis and the reception axis extend at an alignment angle with respect to one another that has a value in the range from 30 degrees to 150 degrees.

Abstract: The present invention provides compounds which are selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.

Abstract: A clamp device for hemostasis or closure of tissue, including clamp housing and at least two clamp arms, wherein clamp arms can be coupled to distal end of control wire of medical instrument to stop bleeding of blood vessel, clamp device can be actuated to open and close clamp arms, which are coupled to each other or can be coupled at proximal ends, clamp arms is provided with guide groove, and guide grooves of clamp arms partially overlap each other, and guide pin attached to clamp housing, and extending in overlapping part of guide grooves and passing therethrough, so that by means of fitting of guide pin and guide grooves, movement of pivot axis is converted into closing movement of clamp arms or opening movement of clamp arms about pivot axis, holding hole being provided on each of clamp arm, holding hole extending from side thereof into guide groove.

Abstract: Substituted tetrazole derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: Disclosed is a medical instrument, comprising: a protective sheath device; a clamp device comprising a clamp shell arranged on a distal end of the protective sheath device and at least or just two clamp arms; and a control line extending and passing through the protective sheath device, wherein the clamp shell is directly connected to the protective sheath device by means of at least one connection element and is fixedly attached to the clamp shell, or, a portion thereof is releasably connected to the protective sheath device; and a release mechanism cooperating with each connection element is provided, and when the clamp arms have been closed, the release mechanism can be actuated by means of moving the control line in a proximal end direction so as to release each connection element from the protective sheath device and thus release the clamp shell.

Abstract: A medical device for tissue hemostasis or closure that is used by means of an endoscope, the medical device comprising: a handle (1); a sheath apparatus (2) attached to the handle (1); a clamping apparatus (3) comprising a clamping base (6) and at least or exactly two clamping arms (7a, 7b), the clamping base (6) specifically being a sleeve and being disposed on a distal end of the sheath apparatus (2); a control wire (4) that extends to pass through the sheath apparatus (2) and that can move reversibly in a distal direction and a proximal direction; and an actuator (5), the actuator (5) being coupled to a proximal end of the control wire (4) and being capable of actuating such that the control wire (4) moves reversibly in the distal direction and the proximal direction.

Abstract: Substituted tetrazole derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: Substituted amide derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: Substituted tetrazole derivatives are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: A clamp device for hemostasis or closure of tissue, including clamp housing and at least two clamp arms, wherein clamp arms can be coupled to distal end of control wire of medical instrument to stop bleeding of blood vessel, clamp device can be actuated to open and close clamp arms, which are coupled to each other or can be coupled at proximal ends, clamp arms is provided with guide groove, and guide grooves of clamp arms partially overlap each other, and guide pin attached to clamp housing, and extending in overlapping part of guide grooves and passing therethrough, so that by means of fitting of guide pin and guide grooves, movement of pivot axis is converted into closing movement of clamp arms or opening movement of clamp arms about pivot axis, holding hole being provided on each of clamp arm, holding hole extending from side thereof into guide groove.

Abstract: Disclosed is a medical instrument, comprising: a protective sheath device; a clamp device comprising a clamp shell arranged on a distal end of the protective sheath device and at least or just two clamp arms; and a control line extending and passing through the protective sheath device, wherein the clamp shell is directly connected to the protective sheath device by means of at least one connection element and is fixedly attached to the clamp shell, or, a portion thereof is releasably connected to the protective sheath device; and a release mechanism cooperating with each connection element is provided, and when the clamp arms have been closed, the release mechanism can be actuated by means of moving the control line in a proximal end direction so as to release each connection element from the protective sheath device and thus release the clamp shell.

Abstract: A medical device for tissue hemostasis or closure that is used by means of an endoscope, the medical device comprising: a handle (1); a sheath apparatus (2) attached to the handle (1); a clamping apparatus (3) comprising a clamping base (6) and at least or exactly two clamping arms (7a, 7b), the clamping base (6) specifically being a sleeve and being disposed on a distal end of the sheath apparatus (2); a control wire (4) that extends to pass through the sheath apparatus (2) and that can move reversibly in a distal direction and a proximal direction; and an actuator (5), the actuator (5) being coupled to a proximal end of the control wire (4) and being capable of actuating such that the control wire (4) moves reversibly in the distal direction and the proximal direction.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation and feedback. The disclosed techniques allow for a graphical user interface to collect and annotate trip data from various sensors integrated in a mobile device for a user. The techniques presented describe the segmentation of the data into one or more populations and the identification of event and behavior features for each segment in order to evaluate a driver's ability. The techniques described present this information to the user through a graphical user interface that includes a driver score and coaching tips to improve the driver's future behavior.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation. The disclosed techniques allow for collecting trip data from various sensors integrated in a mobile device for a user. The techniques include segregating the trip motion data into one or more segments associated with one or more populations with distinct features and characteristics. The trip data can be processed to identify event and behavior features that can be used to evaluate a driver's abilities in a contextually appropriate way. The information for a plurality of drivers can be compared to score the driver's ability amount a plurality of drivers.

Abstract: A hand-held power tool device, in particular a hammer drill and/or chisel hammer device, includes at least one operating element and at least one locking unit. The at least one locking unit includes at least one locking element and at least one controllable actuator element. The at least one locking element can be moved from at least one storage position into at least one locking position, and vice versa, and locks the operating element in at least one operating state in the locking position. The at least one controllable actuator element influences motion of the locking element.

Abstract: Embodiments of the present disclosure present systems, devices, methods, and computer readable medium for contextual driver evaluation. The disclosed techniques allow for collecting trip data from various sensors integrated in a mobile device for a user. The techniques include segregating the trip motion data into one or more segments associated with one or more populations with distinct features and characteristics. The trip data can be processed to identify event and behavior features that can be used to evaluate a driver's abilities in a contextually appropriate way. The information for a plurality of drivers can be compared to score the driver's ability amount a plurality of drivers.

Abstract: A method is provided for identifying an averaged sensor value of a state variable of an air system for an internal combustion engine in a motor vehicle, comprising the following steps: acquiring and temporarily storing sensor values at a predefined sampling interval during a segment duration of the state variable, the segment duration corresponding to one period of a pulsation of the state variable; determining an average of the sensor values acquired within the segment duration; correcting the average of the sensor values that has been determined, using a correction variable that depends on the time difference between the segment duration and a multiple of the sampling interval.

Abstract: For diagnosing a proper functioning of an auxiliary heater in an air mass sensor in an engine system including an internal combustion engine, the auxiliary heater being used for preventing contamination of a sensor area, the air mass sensor communicating air mass information via a signal line during a sensor operating mode and, if a specified state on the signal line is detected, activating the auxiliary heater, the following are performed: setting the state of the signal line to the specified state for a predefined time period in an auxiliary heater operating mode; transmitting a first temperature information before the activation of the auxiliary heater operating mode and a second temperature information via the signal line after expiration of the predefined time period; and detecting the proper functioning of the auxiliary heater depending on the difference between the first temperature information and the second temperature information.

Abstract: A method for diagnosing a malfunction of a sensor system in an air system of an internal combustion engine, said sensor system comprising a first air state sensor, a second air state sensor and a third air state sensor, wherein a first value and a second value of a first comparison variable are ascertained in two different ways in an overall calculation step such that the result of a comparison between the first value and the second value is a function of each of the output variables of the first, second and third air state sensors and wherein in a fault detection step, said method recognizes as a function of the comparison between said first value and said second value of the comparison variable that a fault exists in the sensor system.

Abstract: Compounds of the formula I in which R, R1 and R2 have the meanings indicated in claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus.