Abstract: A system can efficiently determine whether an identity is manipulated. The system can receive entity data and interaction data associated with a target entity. The system can determine, based on the entity data and the interaction data, one or more risk signals associated with the target entity using one or more artificial intelligence models. The system can generate a linked graph structure based on a first graph structure and a second graph structure each generated using the entity data and the interaction data. The system can apply the one or more risk signals to the linked graph structure to determine a risk indicator associated with the target entity. The system can provide a responsive message based on the risk indicator. The responsive message can be used to control access of the target entity to an interactive computing environment.

Abstract: A system can efficiently determine whether an identity is manipulated. The system can receive entity data and interaction data associated with a target entity. The system can determine, based on the entity data and the interaction data, one or more risk signals associated with the target entity using one or more artificial intelligence models. The system can generate a linked graph structure based on a first graph structure and a second graph structure each generated using the entity data and the interaction data. The system can apply the one or more risk signals to the linked graph structure to determine a risk indicator associated with the target entity. The system can provide a responsive message based on the risk indicator. The responsive message can be used to control access of the target entity to an interactive computing environment.

Abstract: Implementations are directed to receiving, by a trusted signing service that is executed in an off-chain network, a user operation, signing, by the trusted signing service, the user operation to provide a signed user operation, receiving, by a paymaster that is executed in a chain network, a call to verify, the call including at least a signature of the signed user operation, and in response to determining that the signature of the signed user operation is valid, providing, by the paymaster and to an entrypoint that is executed in the chain network, a response to the call indicating that the paymaster is verified, the user operation being executed in the chain network at least partially in response to determining that the signature of the signed user operation is valid.

Abstract: A system can efficiently determine whether an identity is manipulated. The system can receive entity data and interaction data associated with a target entity. The system can determine, based on the entity data and the interaction data, one or more risk signals associated with the target entity using one or more artificial intelligence models. The system can generate a linked graph structure based on a first graph structure and a second graph structure each generated using the entity data and the interaction data. The system can apply the one or more risk signals to the linked graph structure to determine a risk indicator associated with the target entity. The system can provide a responsive message based on the risk indicator. The responsive message can be used to control access of the target entity to an interactive computing environment.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: A configurable-mass rideshare dispenser for a launch vehicle (LV). In one embodiment, the rideshare dispenser includes: (1) a modular chassis having an LV mount configured to mount the modular chassis to the LV and an LV interface configured to receive a separation signal from the LV and (2) multiple internal mounts associated with the chassis and operable to mount at multiple candidate locations therein a rideshare payload, signal processing circuitry operable to provide deployment sequencing and commodities for the rideshare payload, and at least one additional mass object.

Abstract: The present invention relates, generally, to asymmetric ?-functionalization and to asymmetric ?,?-bisfunctionalization of ketones and aldehydes and, in particular, to chiral auxiliaries suitable for use in effecting such functionalizations and to methods of using same.

Abstract: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.

Abstract: A console assembly for an automotive vehicle having a housing secured to the vehicle which defines a cavity open at one end of the housing. A drawer support extends outwardly from a lower end of the open end of the housing and at least one track is attached to the drawer support. A drawer has a portion dimensioned to fit within the housing cavity and the drawer is movable between a closed position in which the drawer is positioned within the housing cavity, and an open position in which the drawer overlies the drawer support. At least one shoe is attached to the drawer and slidably mounted to the track so that the shoe slides along the track as the drawer is moved between its open and closed positions. At least one elongated bearing slide assembly is also provided between the drawer and the housing to slidably support the drawer.