Abstract: An apparatus verifies hosted information associated with a user. The apparatus establishes, by the online host serving as a relying party system (RPS), a secure connection between the RPS and a user mobile-identification-credential device (UMD). The RPS sends a mobile identification credential (MIC) user information request to the UMD, via the secure connection, seeking release of MIC user information (official information). The RPS obtains from authorizing party system (APS) verification of the MIC user information received in response to the MIC user information request. The RPS stores the MIC user information as hosted information pertaining to the user. The RPS designates the hosted information as base truth information representing the user.

Abstract: In an example, a provider system receives from a client device a request for client access. The provider system sends to the client device a request for identification information of the client. The provider system receives client information associated with a mobile identification credential (MIC) which the client device received from an authorizing party system (APS), the client having consented to release the client information to the provider system, and the client information having been verified by the APS. The provider system uses the verified client information associated with the MIC to verify or not verify the identity of the client. The provider system verifies the identity of the client before granting the client the request for client access.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light.

Abstract: The present disclosure relates generally to detection of long noncoding RNA (lncRNA) molecules in a sample or diagnosis of subject based upon detection of long noncoding RNAs in a sample, specifically to identify and use of molecular biomarkers or cancer including malignant glioma. Also provided are compositions and methods for treating malignant glioma in a subject, as well as human brain organoid models of malignant glioma and methods of generating and using the same.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: Disclosed is a method of generating a functional singularity at a point or collection of points. The method may include determining a relationship between one or more parameters associated with a physical structure and a spatial gradient of field values of at least one of electromagnetic energy, sound energy, particle beam, or water waves manipulated by the physical structure, configuring, according to the relationship, the spatial gradient of field values to represent a functional singularity at a point, performing backpropagation using the spatial gradient of field values to obtain design parameters corresponding to values for the one or more parameters that achieve the functional singularity at the point, and producing a physical structure having the design parameters.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: A system and method for an enhanced interconnect for downhole tools along a drill string used in subterranean operations is described herein. The system (300) may include a first drill string segment (302) comprising a first conductive element (306) and a second drill string segment (304) coupled to the first drill string segment. The system may also include a tool connect assembly (310) disposed within an internal bore of the second drill string segment. The tool connect assembly may comprise a second conductive element (312) electrically connected to the downhole tool, and the second conductive element may be electrically coupled to the first conductive element through at most two electrical interfaces.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.