Abstract: A system can efficiently determine whether an identity is manipulated. The system can receive entity data and interaction data associated with a target entity. The system can determine, based on the entity data and the interaction data, one or more risk signals associated with the target entity using one or more artificial intelligence models. The system can generate a linked graph structure based on a first graph structure and a second graph structure each generated using the entity data and the interaction data. The system can apply the one or more risk signals to the linked graph structure to determine a risk indicator associated with the target entity. The system can provide a responsive message based on the risk indicator. The responsive message can be used to control access of the target entity to an interactive computing environment.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: Disclosed is a method of generating a functional singularity at a point or collection of points. The method may include determining a relationship between one or more parameters associated with a physical structure and a spatial gradient of field values of at least one of electromagnetic energy, sound energy, particle beam, or water waves manipulated by the physical structure, configuring, according to the relationship, the spatial gradient of field values to represent a functional singularity at a point, performing backpropagation using the spatial gradient of field values to obtain design parameters corresponding to values for the one or more parameters that achieve the functional singularity at the point, and producing a physical structure having the design parameters.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: An optical device includes a membrane. The membrane includes a plurality of apertures extending at least partially through a thickness of the membrane. The membrane is configured to structure incoming light having a wavelength to produce modified light. The wavelength of the incoming light in vacuum is in a range of ultraviolet light and mid-infrared. The membrane is configured to reflect the modified light away from the membrane or transmit the modified light through the membrane. A separation between each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A width of each of the plurality of apertures is subwavelength relative to the wavelength of the incoming light. A length of each of the plurality of apertures is wavelength-scale relative to the wavelength of the incoming light.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: The disclosure provides a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV. In one example, the configurable-mass rideshare dispenser includes: (1) a modular chassis having a plurality of walls, wherein each of the plurality of walls includes multiple internal mounts operable to mount at multiple candidate locations a rideshare payload, its associated attachment/deployment mechanisms, signal processing circuitry, and at least one additional mass object, and (2) at least one door coupled to at least one of the plurality of walls, wherein the signal processing circuitry is operable to provide deployment sequencing that operates the at least one door.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: A system and method for an enhanced interconnect for downhole tools along a drill string used in subterranean operations is described herein. The system (300) may include a first drill string segment (302) comprising a first conductive element (306) and a second drill string segment (304) coupled to the first drill string segment. The system may also include a tool connect assembly (310) disposed within an internal bore of the second drill string segment. The tool connect assembly may comprise a second conductive element (312) electrically connected to the downhole tool, and the second conductive element may be electrically coupled to the first conductive element through at most two electrical interfaces.

Abstract: A rideshare adapter for a launch vehicle (LV), a configurable-mass rideshare dispenser for a rideshare adapter employable with a LV, and a method of operating a configurable-mass rideshare dispenser for an LV are disclosed herein. In one embodiment, the rideshare adapter includes: (1) an annular peripheral wall that defines an interior of the rideshare adapter and (2) inner support walls, mechanically coupled to the peripheral wall, that are located within the interior and divide the interior into multiple rideshare dispenser compartments.

Abstract: A configurable spacecraft attachment and deployment system and a method of constructing a configurable spacecraft attachment and deployment system are provided herein. In one embodiment, the configurable spacecraft attachment and deployment system includes: (1) a connecting structure configured to secure at least one spacecraft to a launch interface, (2) an actuating assembly configured to constrain the spacecraft to the connecting structure before deployment thereof and release the spacecraft from the connecting structure when deployed, and (3) a deploying mechanism coupled to the connecting structure and configured to eject the spacecraft from the attaching structure, wherein the connecting structure, the actuating assembly, and the deploying mechanism are modular components and the connecting structure and deploying mechanism are selected to form the system based on parameters of the spacecraft.

Abstract: A configurable-mass rideshare dispenser for a launch vehicle (LV). In one embodiment, the rideshare dispenser includes: (1) a modular chassis having an LV mount configured to mount the modular chassis to the LV and an LV interface configured to receive a separation signal from the LV and (2) multiple internal mounts associated with the chassis and operable to mount at multiple candidate locations therein a rideshare payload, signal processing circuitry operable to provide deployment sequencing and commodities for the rideshare payload, and at least one additional mass object.

Abstract: According to aspects of the present disclose, a system and method for an enhanced interconnect for downhole tools along a drill string used in subterranean operations is described herein. The system (300) may include a first drill string segment (302) comprising a first conductive element (306) and a second drill string segment (304) coupled to the first drill string segment. The system may also includes a tool connect assembly (310) disposed within an internal bore of the second drill string segment. The tool connect assembly may comprise a second conductive element (312) electrically connected to the downhole tool, and the second conductive element may be electrically coupled to the first conductive element through at most two electrical interfaces.

Abstract: The present invention relates, generally, to asymmetric ?-functionalization and to asymmetric ?,?-bisfunctionalization of ketones and aldehydes and, in particular, to chiral auxiliaries suitable for use in effecting such functionalizations and to methods of using same.