Abstract: Lysyl oxidase (LOX) inhibitors, lysyl oxidase-like (LOXL) inhibitors, or pharmaceutically acceptable salts thereof and methods for the treatment of myeloid malignancies, comprising administering a therapeutically effective amount of those inhibitors alone or optionally in combination with a second therapeutic agent.

Abstract: An electronic device having an auto-on circuit is provided. The electronic device can include a charging circuit and a control circuit. The control circuit can cause the charging circuit to deliver energy to an external device. The auto-on circuit, which can include an active circuit, can activate the control circuit in response to one or more trigger input circuits. Each trigger input circuit can actuate a switch and deliver an auto-on signal to the control circuit. The control circuit can then actuate a latch to deliver power to a power input terminal to keep itself powered ON.

Abstract: A method and apparatus charge devices using a multiple port power supply. The apparatus can include a power supply. The apparatus can include a first device charging port coupled to the power supply. The first device charging port can receive power from the power supply and output power to a first device. The apparatus can include a second device charging port coupled to the power supply. The second device charging port can receive power from the power supply and output power to a second device. The apparatus can include a device charging port monitor coupled to the first device charging port and coupled to the second device charging port. The device charging port monitor can detect a number of device charging ports in use. The apparatus can include a cable compensator coupled to the device charging port monitor. The cable compensator can select a first cable compensation if one device charging port is in use and can select a second cable compensation if two device charging ports are in use.

Abstract: An electronic device having an auto-on circuit is provided. The electronic device can include a power supply or charging circuit and a control circuit. The control circuit can cause the power supply or charging circuit to deliver energy to an external device. The auto-on circuit can activate the control circuit in response to one or more trigger input circuits. Each trigger input circuit can actuate a switch and deliver an auto-on signal to the control circuit. The control circuit can then actuate a latch to deliver power to a power input terminal to keep itself powered ON.

Abstract: An electronic device having an auto-on circuit is provided. The electronic device can include a charging circuit and a control circuit. The control circuit can cause the charging circuit to deliver energy to an external device. The auto-on circuit, which can include an active circuit, can activate the control circuit in response to one or more trigger input circuits. Each trigger input circuit can actuate a switch and deliver an auto-on signal to the control circuit. The control circuit can then actuate a latch to deliver power to a power input terminal to keep itself powered ON.

Abstract: A method and apparatus charge devices using a multiple port power supply. The apparatus can include a power supply. The apparatus can include a first device charging port coupled to the power supply. The first device charging port can receive power from the power supply and output power to a first device. The apparatus can include a second device charging port coupled to the power supply. The second device charging port can receive power from the power supply and output power to a second device. The apparatus can include a device charging port monitor coupled to the first device charging port and coupled to the second device charging port. The device charging port monitor can detect a number of device charging ports in use. The apparatus can include a cable compensator coupled to the device charging port monitor. The cable compensator can select a first cable compensation if one device charging port is in use and can select a second cable compensation if two device charging ports are in use.

Abstract: A method for forming a protective coating on a substrate comprising, applying a bond coating to the substrate, the bond coating having a first surface roughness, ionizing an inert gas which flows into the surface of the bond coating so as to impart a second surface roughness to the bond coating greater than the first surface roughness, wherein the inert gas is ionized and caused to flow into the surface of the bond coating by a reverse polarity current supplied to an electrode which removes at least one electron from the inert gas, and applying a top coating to the bond coating. Additionally, a method for preparing a surface to receive and adhere to a coating comprising roughening the surface to create a micro-roughening network on the surface. In addition, a method of improving strain tolerance and cyclic spallation life of a protective coating.

Abstract: A method of fabricating a machine component is provided. The method includes preparing at least a portion of a surface of a machine component for receiving a sintered preform. The method also includes forming a pre-sintered preform hybrid hardface mixture that includes combining a predetermined portion of at least one hardfacing material with a predetermined portion of at least one brazing material. The method further includes forming a pre-sintered preform. The pre-sintered preform has predetermined dimensions. The method also includes forming the sintered preform and positioning the sintered preform on the machine component. The method further includes fixedly coupling the sintered preform to at least a portion of the machine component via brazing.

Abstract: A method for forming a protective coating on a substrate comprising, applying a bond coating to the substrate, the bond coating having a first surface roughness, ionizing an inert gas which flows into the surface of the bond coating so as to impart a second surface roughness to the bond coating greater than the first surface roughness, wherein the inert gas is ionized and caused to flow into the surface of the bond coating by a reverse polarity current supplied to an electrode which removes at least one electron from the inert gas, and applying a top coating to the bond coating. Additionally, a method for preparing a surface to receive and adhere to a coating comprising roughening the surface to create a micro-roughening network on the surface. In addition, a method of improving strain tolerance and cyclic spallation life of a protective coating.

Abstract: An explosion-welded turbine shroud and a process of forming an explosion-welded gas turbine shroud are disclosed. The explosion-welded gas turbine shroud includes a first alloy explosion welded to a second alloy. In the explosion-welded gas turbine shroud, the first alloy forms at least a portion of a hot gas path or an expansion region of the gas turbine shroud includes the first alloy. The process includes explosion welding a first alloy to a second alloy to form the gas turbine shroud.

Abstract: An article and method of forming the article are disclosed. The method includes positioning a first workpiece, positioning a second workpiece, and applying energy to the first workpiece and the second workpiece to form a weld. The article includes the first and second workpiece. The first workpiece includes a first weld surface, which includes at least one porosity reducing channel. The second workpiece includes a second weld surface positioned to be welded to the first weld surface. The application of energy generates gas that is directed by the at least one porosity reducing channel.

Abstract: A system in a turbine engine for preventing wear on a tip shroud of a turbine blade that includes a pocket formed in a contact surface of the tip shroud and a plug that fits within the pocket and has a durable outer surface. The durable outer surface may include a cobalt-based hardfacing powder. The pocket may be machined out of the contact surface, and the plug may include a plug of predetermined size that fits snugly into the pocket. In some embodiments, the durable outer surface may substantially align with the contact surface after the plug is fitted into the pocket. In other embodiments, the durable outer surface may remain slightly raised from the contact surface after the plug has been fitted into the pocket.

Abstract: A tip cap for use in a turbine bucket. The tip cap may include a shield of an oxidant resistant material and a cap positioned within the shield of a high strength material.

Abstract: A gas turbine assembly includes a shroud that includes a plurality of interconnected shroud segments, wherein each one of the shroud segments comprises an arcuate base formed of a first metal material. The arcuate base is made up of an annular member having an axial component and a pair of upstanding ribs having flanges, wherein the arcuate base further comprises a high temperature capable material layer disposed on a surface of the arcuate base so as to define an inner diameter of the shroud segment (i.e., the hot gas path side or environmental side).

Abstract: A method of welding superalloy components comprising: pre-heat one or more components to be welded to a temperature of at least 1500° F. in a substantially enclosed inert gas atmosphere; supplying multiple fillers to the weld zone, at least two of said fillers having different compositions; and welding the one or more preheated components utilizing a laser beam, while maintaining said pre-heat temperature.

Abstract: A system in a turbine engine for preventing wear on a tip shroud of a turbine blade that includes a pocket formed in a contact surface of the tip shroud and a plug that fits within the pocket and has a durable outer surface. The durable outer surface may include a cobalt-based hardfacing powder. The pocket may be machined out of the contact surface, and the plug may include a plug of predetermined size that fits snugly into the pocket. In some embodiments, the durable outer surface may substantially align with the contact surface after the plug is fitted into the pocket. In other embodiments, the durable outer surface may remain slightly raised from the contact surface after the plug has been fitted into the pocket.

Abstract: A method of welding superalloy components comprising: preheating one or more components to be welded to a target temperature of at least 1500OF in a vacuum chamber; welding the one or more preheated components in a weldment region utilizing an electron beam, while maintaining the target temperature until welding is completed.

Abstract: A method of welding superalloy components comprising: (a) forming a weld prep groove at an interface of the components; (b) welding the components using a filler material at ambient temperature; (c) covering the filler material and adjacent surfaces of the components with a braze paste; and (d) heat treating the components, the heat treatment including a stress-relief cycle and a braze cycle. A similar process may be used to repair a crack in a nickel-based superalloy component.

Abstract: Disclosed herein is a method of welding superalloy articles. A buttered layer is attached to a first article formed from a superalloy. A buttered layer is attached to a second article formed from a superalloy. Residual stresses are relieved between the buttered layer and the superalloy. Matching faying surfaces are established at the buttered layers of the articles. And, the faying surfaces of the articles are welded together to form a welded assembly, wherein after welding, a heat affected zone is within the buttered layers.

Abstract: A method for forming a protective coating on a substrate comprising, applying a bond coating to the substrate, the bond coating having a first surface roughness, ionizing an inert gas which flows into the surface of the bond coating so as to impart a second surface roughness to the bond coating greater than the first surface roughness, wherein the inert gas is ionized and caused to flow into the surface of the bond coating by a reverse polarity current supplied to an electrode which removes at least one electron from the inert gas, and applying a top coating to the bond coating. Additionally, a method for preparing a surface to receive and adhere to a coating comprising roughening the surface to create a micro-roughening network on the surface. In addition, a method of improving strain tolerance and cyclic spallation life of a protective coating.