Abstract: The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.

Abstract: The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.

Abstract: A method of playout buffer management includes delivering AV data to a destination device at a rate greater than the rate at which the destination device consumes data; rendering of AV data upon receipt of a first AV data packet while simultaneously filling a playout buffer; and flushing the playout buffer upon receipt of a command taken from the group of commands consisting of change of AV program, receipt of a new AV stream following a fast forward or fast reverse command, a pause command and a stop command.

Abstract: Embodiments of the present invention comprise systems and methods for detecting and applying network channel characteristic measurements.

Abstract: Embodiments of the present invention comprise systems and methods for network connection setup and bandwidth allocation comprising negotiable and non-negotiable modulation allocation procedures.

Abstract: Embodiments of the present invention comprise methods and systems for establishment and modification of network allocation parameters.

Abstract: An image transfer mechanism for a printer having a printer frame and an imaging drum attached to the printer frame includes a roller arm having a proximal end and a distal end, a transfer roller having a longitudinal axis, and a load arm having a proximal end and a distal end. The axis of the transfer roller is rotatably attached to the roller arm. The proximal end of the roller arm is attached to the load arm between the proximal end and the distal end of the load arm. The proximal end of the load arm is pivotally attached to the printer frame, and a load mechanism applies a load force to the distal end of the load arm to urge the load arm toward the imaging drum. An engaging mechanism selectively urges the distal end of the roller arm toward the imaging drum, which presses the load arm against the load force of the load mechanism.

Abstract: An image transfer mechanism includes a pressure element and a lever system. The lever system has a load attachment point with a range of position that depends on the thickness of a print medium positioned between the imaging element and the pressure element. A load mechanism includes a load connector with a distal end attached to the lever system load attachment point so that displacement of the lever system attachment point causes longitudinal movement of the load connector. The load mechanism applies a load that is substantially constant throughout the range of position of the lever system load attachment point. The load mechanism includes a spring and a crank attached to the spring and to the proximal end of the load connector. The crank is configured so that a change in the spring force produces a lesser change in the load force at the distal end of the load connector.

Abstract: A method of controlling packet transmission in a power line communication (PLC)-based local area network (LAN) including providing a PLC centrol coordinator in the PLC LAN for managing allocation of PLC LAN resources; and providing, for any packet traversing the PLC LAN, a destination station MAC address, a source station MAC address, and a temporary equipment identifier (TEI) for the transmitting PLC station.

Abstract: A web application that enables access to a client's specific account transaction detail. The charge transaction detail can include anything related to charge or credit card transactions including travel transaction detail, corporate card detail and corporate purchasing card detail. The transaction detail can be captured from many sources and can include third party data. The clients can use a web application and web page to access the account data and create report views of the information. The system can also includes a create a report capability, which allows users to add filters and data elements to an existing report format and create a report specific to their needs and data.