Patents by Inventor Daniel Paul Teufel

Daniel Paul Teufel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP
    Publication number: 20240082410
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: May 11, 2023
    Publication date: March 14, 2024
    Inventors: Daniel Paul TEUFEL, Catherine Lucy STACE, Silvia PAVAN, Edward WALKER, Leonardo BALDASSARRE
  • Peptide ligands for binding to EphA2
    Patent number: 11814447
    Abstract: A peptide ligand specific for EphA2 comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlkDap), with the proviso that at least one of said three residues is selected from Dap, N-AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: November 14, 2023
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Gemma Mudd, Silvia Pavan
  • Modulation of structured polypeptide specificity
    Patent number: 11753444
    Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: September 12, 2023
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
  • Bicyclic peptide ligands with detectable moieties and uses thereof
    Patent number: 11746126
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: September 5, 2023
    Assignee: BicycleRD Limited
    Inventors: Gavin Bennett, Daniel Paul Teufel
  • Bicyclic peptide ligands specific for MT1-MMP
    Patent number: 11672868
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: June 13, 2023
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • Compounds for treating cancer
    Patent number: 11433137
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 6, 2022
    Assignee: BICYCLERD LIMITED
    Inventors: Gavin Bennett, Daniel Paul Teufel
  • Bicyclic peptide ligands and uses thereof
    Patent number: 11241473
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: February 8, 2022
    Assignee: BicycleTx Limited
    Inventors: Paul John Beswick, Gabriela Ivanova-Berndt, Gemma Elizabeth Mudd, Silvia Pavan, Michael Skynner, Daniel Paul Teufel, Katerine Van Rietschoten
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP
    Publication number: 20220023432
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: July 22, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Paul TEUFEL, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • Bicyclic peptide ligands specific for MT1-MMP
    Patent number: 11103591
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: August 31, 2021
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF
    Publication number: 20210079045
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 1, 2020
    Publication date: March 18, 2021
    Inventors: Gavin BENNETT, Daniel Paul TEUFEL
  • MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY
    Publication number: 20210079043
    Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.
    Type: Application
    Filed: August 7, 2020
    Publication date: March 18, 2021
    Inventors: Daniel Paul Teufel, Catherine STACE, Edward WALKER, John TITE
  • BICYCLIC PEPTIDE LIGANDS AND USES THEREOF
    Publication number: 20210046145
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 2, 2020
    Publication date: February 18, 2021
    Inventors: Paul John Beswick, Gabriela Ivanova-Berndt, Gemma Elizabeth Mudd, Silvia Pavan, Michael Skynner, Daniel Paul Teufel, Katerine Van Rietschoten
  • Bicyclic peptide ligands with detectable moieties and uses thereof
    Patent number: 10899798
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: January 26, 2021
    Assignee: BicycleRD Limited
    Inventors: Gavin Bennett, Daniel Paul Teufel
  • Modulation of structured polypeptide specificity
    Patent number: 10870679
    Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 22, 2020
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
  • Bicyclic peptide ligands and uses thereof
    Patent number: 10857196
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 8, 2020
    Assignee: BicycleTx Limited
    Inventors: Paul John Beswick, Gabriela Ivanova-Berndt, Gemma Elizabeth Mudd, Silvia Pavan, Michael Skynner, Daniel Paul Teufel, Katerine Van Rietschoten
  • Bicyclic peptide ligands specific for MT1-MMP
    Patent number: 10792368
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: October 6, 2020
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP
    Publication number: 20200289657
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: April 2, 2020
    Publication date: September 17, 2020
    Inventors: Daniel Paul Teufel, Catherine Lucy STACE, Silvia PAVAN, Edward WALKER, Leonardo BALDASSARRE
  • COMPOUNDS FOR TREATING CANCER
    Publication number: 20200215199
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 16, 2019
    Publication date: July 9, 2020
    Inventors: Gavin Bennett, Daniel Paul Teufel
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP
    Publication number: 20200171161
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 4, 2020
    Inventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • Compounds for treating cancer
    Patent number: 10624968
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: April 21, 2020
    Assignee: BICYCLERD LIMITED
    Inventors: Gavin Bennett, Daniel Paul Teufel