Patents by Inventor Daniel Paul Teufel
Daniel Paul Teufel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10532106Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.Type: GrantFiled: October 29, 2015Date of Patent: January 14, 2020Assignee: BICYCLERD LIMITEDInventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassare
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Patent number: 10441663Abstract: The present invention relates to a method of treating cancer in a subject.Type: GrantFiled: November 27, 2017Date of Patent: October 15, 2019Assignee: BICYCLERD LIMITEDInventors: Gavin Bennett, Daniel Paul Teufel
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Publication number: 20180371020Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.Type: ApplicationFiled: June 26, 2018Publication date: December 27, 2018Inventors: Gavin Bennett, Daniel Paul Teufel
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Publication number: 20180362585Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.Type: ApplicationFiled: June 20, 2018Publication date: December 20, 2018Inventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
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Patent number: 10118947Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.Type: GrantFiled: April 11, 2014Date of Patent: November 6, 2018Assignee: BicycleRD LimitedInventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
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Publication number: 20180311300Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.Type: ApplicationFiled: April 27, 2018Publication date: November 1, 2018Inventors: Paul John Beswick, Gabriela Ivanova-Berndt, Gemma Elizabeth Mudd, Silvia Pavan, Michael Skynner, Daniel Paul Teufel, Katerine Van Rietschoten
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Publication number: 20180280525Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP).The invention also describes drug conjugates comprising said peptides,conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.Type: ApplicationFiled: October 29, 2015Publication date: October 4, 2018Inventors: Daniel Paul TEUFEL, Catherine Lucy STACE, Silvia PAVAN, Edward WALKER, Leonardo BALDASSARRE
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Publication number: 20180200378Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.Type: ApplicationFiled: January 5, 2018Publication date: July 19, 2018Inventors: Gavin Bennett, Daniel Paul Teufel
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Publication number: 20180169254Abstract: The present invention relates to a method of treating cancer in a subject.Type: ApplicationFiled: November 27, 2017Publication date: June 21, 2018Inventors: Gavin Bennett, Daniel Paul Teufel
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Patent number: 9670482Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: GrantFiled: November 26, 2013Date of Patent: June 6, 2017Assignee: BICYCLE THERAPEUTICS LIMITEDInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Publication number: 20170067045Abstract: The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).Type: ApplicationFiled: November 17, 2016Publication date: March 9, 2017Inventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, Daniel Paul Teufel
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Patent number: 9518081Abstract: The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).Type: GrantFiled: August 12, 2010Date of Patent: December 13, 2016Assignee: BICYCLE THERAPEUTICS LIMITEDInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, Daniel Paul Teufel
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Publication number: 20160046673Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.Type: ApplicationFiled: April 11, 2014Publication date: February 18, 2016Applicant: BICYCLE THERAPEUTICS LIMITEDInventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
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Publication number: 20140163201Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: ApplicationFiled: November 26, 2013Publication date: June 12, 2014Applicant: BICYCLE THERAPEUTICS LIMITEDInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Patent number: 8685890Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: GrantFiled: February 4, 2010Date of Patent: April 1, 2014Assignee: Bicycle Therapeutics LimitedInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
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Publication number: 20120172235Abstract: The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c).Type: ApplicationFiled: August 12, 2010Publication date: July 5, 2012Applicant: Medical Research CouncilInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, Daniel Paul Teufel
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Publication number: 20120101256Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: ApplicationFiled: February 4, 2010Publication date: April 26, 2012Applicant: Medical Research CouncilInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann