Abstract: A smart speaker power controller may be configured to receive power conforming to one of a plurality of power modes from an input power source. The power controller may be further configured to communicate the power mode to at least one component of a processing system or at least one component of an audio system for operating the smart speaker according to the received power mode, including determining a current limit of a power converter; determining a shutdown voltage threshold and safely shutting down the smart speaker if the input voltage falls below the threshold, and/or modifying audio operation of the smart speaker in response to the power mode. The smart speaker can further include an audio power supply controller configured to monitor energy required to reproduce an audio signal and to servo a power supply voltage provided to an audio amplifier in response to this energy level.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

Abstract: The present invention provides a composition and method for preventing the growth of and/or treating cancerous tumors and/or delaying onset of cancer from tumor-initiating cells. The composition includes an effective amount of a compound of Formula (I) or Formula (II): or any pharmaceutically acceptable salt thereof. The composition is administered alone or in combination with one or more chemotherapeutic agents, biological agents and/or anticancer agents. The method may include administering the composition of the present invention with or without the chemotherapeutic, biological, or other cancer treatment agent to a subject in need thereof intravenously, parenterally, nasally, topically or locally, orally, or by liposome, implant or via vessel-targeted nanosuspension delivery.

Abstract: Compounds and compositions, for example vardenafil, for treating diseases and/or conditions caused by, arising from, and/or associated with coronavirus in a subject, for example a subject infected with SARS-CoV-2 or other coronavirus. Combinations of agents useful for treating diseases and/or conditions caused by, arising from, and/or associated with coronavirus in a subject, for example, vardenafil and Remdesivir, are also provided.

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: The present invention provides a composition and method for preventing the growth of and/or treating cancerous tumors and/or delaying onset of cancer from tumor-initiating cells. The composition includes an effective amount of a compound of Formula (I) or Formula (II): or any pharmaceutically acceptable salt thereof. The composition is administered alone or in combination with one or more chemotherapeutic agents, biological agents and/or anticancer agents. The method may include administering the composition of the present invention with or without the chemotherapeutic, biological, or other cancer treatment agent to a subject in need thereof intravenously, parenterally, nasally, topically or locally, orally, or by liposome, implant or via vessel-targeted nanosuspension delivery.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: A protective case for a mobile electronic device is disclosed herein. The protective case includes a front portion and a back portion that is configured to slide into a side of the front portion to effectuate the sealing and closure of the case. The front portion is configured to cover the front face and sides of the device and includes rails or protrusions on opposing sides of its internal surface. The back portion is configured to cover the back side of the device and includes channels on opposing sides that are configured to be slid along the rails on the opposing sides of the internal surface of the front component arid thereby open and close the case. The protective case is configured to be reversibly attached to a stand that facilitates multiple viewing/operating positions.

Abstract: A protective case for a mobile electronic device having a touchscreen constructed from at least two separate frame components is disclosed herein. The frame components include a back frame and a front frame or cover. In some embodiments, when a mobile electronic device is held within the back frame, a stretchable cover is stretched over the back frame and device to securely hold the device within the back frame. The front frame or cover includes a touchscreen cover. The front frame or cover is removably coupled to the back frame with grasping protrusions or engagement members that engage with corresponding components of the back frame.

Abstract: A protective case for a mobile device that includes a back frame and a front cover is disclosed herein. The back frame has a rigid plastic back frame with are elastomeric material bonded to portions of the plastic frame. An elastomeric insert is positioned around a portion of the interior perimeter of the back frame to provide impact resistance. Back frame engagement members are positioned on the perimeter of the rigid plastic back frame. The front cover mates with the back frame to enclose the elastomeric insert and the device. The front cover includes a touch screen cover and a rigid plastic front frame bonded to a perimeter of the touch screen cover. Front cover engagement members extend from the rigid plastic front frame that engage the back frame engagement members to bold the front cover on the back frame and enclose the device.

Abstract: A protective case for a portable device having a touchscreen constructed from a back frame, a front frame, and a stretchable cover is disclosed herein. The back frame receives the device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and device such that the device is securely held in the back frame. A front frame with a transparent screen protector that allows the touch screen of the device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping protrusions that connect to mounting portions on the back frame that extend through openings in the stretchable cover.

Abstract: A protective case for a mobile electronic device is disclosed herein. The protective case includes a front portion and a back portion that is configured to slide into a side of the front portion to effectuate the sealing and closure of the case. The front portion is configured to cover the front face and sides of the device and includes rails or protrusions on opposing sides of its internal surface. The back portion is configured to cover the hack side of the device and includes channels on opposing sides that are configured to be slid along the rails on the opposing sides of the internal surface of the front component and thereby open and close the case. The protective case is configured to be reversibly attached to a stand that facilitates multiple viewing/operating positions.

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

Abstract: The present invention provides a composition and method for preventing the growth of and/or treating cancerous tumors and/or delaying onset of cancer from tumor-initiating cells. The composition includes an effective amount of a compound of Formula (I) or Formula (II): or any pharmaceutically acceptable salt thereof. The composition is administered alone or in combination with one or more chemotherapeutic agents, biological agents and/or anticancer agents. The method may include administering the composition of the present invention with or without the chemotherapeutic, biological, or other cancer treatment agent to a subject in need thereof intravenously, parenterally, nasally, topically or locally, orally, or by liposome, implant or via vessel-targeted nanosuspension delivery.

Abstract: A protective case for a portable device having a touchscreen constructed from a back frame, a front frame, and a stretchable cover is disclosed herein. The back frame receives the device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and device such that the device is securely held in the back frame. A front frame with a transparent screen protector that allows the touch screen of the device to be used while the device is frilly enclosed in the case is removably coupled to the back frame with grasping protrusions that connect to mounting portions on the back frame that extend through openings in the stretchable cover.

Abstract: A case for a portable electronic device that includes a device stand attached to a back surface of the case housing is disclosed herein. The device stand is formed by an inner stand and an outer stand connected by releasable hinged connections that are connected to the back surface of the case housing. One or more tracks are formed on an inner surface of the outer stand. The inner stand slides along the one or more tracks. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the case causes the portion of the outer stand to flex, releasing the inner stand from the locking portion to allow the inner and outer stands to be closed.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.