Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: A water resistant device case includes a front and back assembly that mate to enclose an electronic device. The front assembly includes a rigid front frame, a touch screen cover bonded to the front frame, an inner bumper attached to the rigid front frame and an elastomeric main seal attached around a periphery of the rigid front frame. The back assembly includes a rigid back frame, an elastomeric over mold formed on an exterior of the back frame and an inner bumper attached to the rigid back frame. A snap tab attached to the rigid back frame mates with a snap hook on the front assembly to hold the front and back assemblies together when the device is enclosed within the case. A main water resistant seal is formed around a perimeter of the front and back assemblies by the elastomeric main seal on the front assembly being held against an inner surface of the rigid back frame.

Abstract: A protective case for a mobile or portable electronic device is disclosed. The protective case includes a front portion and a back portion that is configured to slide into a side of the front portion to effectuate the sealing and closure of the case. The front portion is configured to cover the front face and sides of the electronic device and includes rails or protrusions on opposing sides of its internal surface. The back portion is configured to cover the back side of the electronic device and includes channels on opposing sides that are configured to be slide along the rails on the opposing sides the internal surface of the front component and thereby open and close the case. The protective case is configured to be reversibly attached to a stand module that facilitates multiple viewing/operating positions.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: A protective case for a portable device having a touch screen is constructed from a back frame, a front frame and a stretchable cover. The back frame receives the portable device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and portable device such that the portable device is securely held in the back frame and the touch screen can be accessed and used when the device is mounted in the back frame and stretchable cover. A front frame with a transparent screen protector that allows the touch screen of the portable device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping arms that connect to mounting portions on the back frame that extend through openings in the stretchable cover. A debris resistant seal is created between the front frame and the stretchable cover through a compression fit.

Abstract: A water resistant device case includes a front and back assembly that mate to enclose an electronic device. The front assembly includes a rigid front frame, a touch screen cover bonded to the front frame, an inner bumper attached to the rigid front frame and an elastomeric main seal attached around a periphery of the rigid front frame. The back assembly includes a rigid back frame, an elastomeric over mold formed on an exterior of the back frame and an inner bumper attached to the rigid back frame. A snap tab attached to the rigid back frame mates with a snap hook on the front assembly to hold the front and back assemblies together when the device is enclosed within the case. A main water resistant seal is formed around a perimeter of the front and back assemblies by the elastomeric main seal on the front assembly being held against an inner surface of the rigid back frame.

Abstract: A coil spring for use in a cavity, such as in a groove of a pin, a housing, or both. The cavity can also be part of a seal assembly. The coil spring can have a longitudinal component positioned within the plurality of interconnected coils that runs along the spring coil axis in order to increase rigidity of the coil spring. The longitudinal component applies a load against the coil spring and/or provides restriction against the coil spring taking a shape or size different than that of the coil spring retaining groove.

Abstract: A protective case for a portable electronic device includes a rigid plastic frame bonded to a stretchable rubber cover and a back panel insert that can be removably inserted into a pocket in the rear of the stretchable rubber cover and plastic frame. To position a device in the case, the device is simply inserted into the front opening of the rigid plastic frame and stretchable rubber cover such that the edges of the stretchable cover stretch over the device and secure the device in the case. A variety of different removable back panels allow the stand to be easily reconfigured to include a stand for the device case, a pocket adapted to hold payment cards, a folding style wallet, a mirror or a fabric covering.

Abstract: A protective case for a portable device having a touch screen is constructed from a back frame, a front frame and a stretchable cover. The back frame receives the device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and device such that the device is securely held in the back frame. A front frame with a transparent screen protector that allows the touch screen of the portable device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping protrusions or arms that connect to mounting portions on the back frame that extend through openings in the stretchable cover.

Abstract: A device case for a portable electronic device includes a device stand attached to a hack surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the back surface of the case housing. A track is formed on a surface of the outer stand that the inner stand slides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.

Abstract: A coil spring for use in a cavity, such as in a groove of a pin, a housing, or both. The cavity can also be part of a seal assembly. The coil spring can have a longitudinal component positioned within the plurality of interconnected coils that runs along the spring coil axis in order to increase rigidity of the coil spring. The longitudinal component applies a load against the coil spring and/or provides restriction against the coil spring taking a shape or size different than that of the coil spring retaining groove.

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Abstract: A protective case for a portable electronic device includes a rigid plastic frame bonded to a stretchable rubber cover and a back panel insert that can be removably inserted into a pocket in the rear of the stretchable rubber cover and plastic frame. To position a device in the case, the device is simply inserted into the front opening of the rigid plastic frame and stretchable rubber cover such that the edges of the stretchable cover stretch over the device and secure the device in the case. A variety of different removable back panels allow the stand to be easily reconfigured to include a stand for the device case, a pocket adapted to hold payment cards, a folding style wallet, a mirror or a fabric covering.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: A device case for a portable electronic device includes a device stand attached to a back surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the back surface of the case housing. A track is formed on a surface of the outer stand that the inner stand slides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.

Abstract: A protective case for a portable device having a touch screen is constructed from a back frame, a front frame and a stretchable cover. The back frame receives the portable device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and portable device such that the portable device is securely held in the back frame and the touch screen can be accessed and used when the device is mounted in the back frame and stretchable cover. A front frame with a transparent screen protector that allows the touch screen of the portable device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping arms that connect to mounting portions on the back frame that extend through openings in the stretchable cover. A debris resistant seal is created between the front frame and the stretchable cover through a compression fit.

Abstract: A device case for a portable electronic device includes a device stand attached to a hack surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the back surface of the case housing. A track is formed on a surface of the outer stand that the inner stand slides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.