Patents by Inventor Daniel R. Soppet
Daniel R. Soppet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6953667Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: January 25, 2002Date of Patent: October 11, 2005Assignee: Human Genome Sciences, Inc.Inventors: Paul A. Moore, Steven M. Ruben, Henrik S. Olsen, Yanggu Shi, Craig A. Rosen, Kimberly A. Florence, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, George Komatsoulis, Roxanne D. Duan
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Patent number: 6936691Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: April 11, 2001Date of Patent: August 30, 2005Assignee: Human Genome Sciences, Inc.Inventors: Michele Fiscella, Ping Wei, David W. LaFleur, Henrik S. Olsen, Kevin P. Baker, Reinhard Ebner, George A. Komatsoulis, Craig A. Rosen, Steven M. Ruben, Roxanne D. Duan, Paul E. Young, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Jian Ni, Daniel R. Soppet, Yanggu Shi
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Patent number: 6919433Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: May 11, 2001Date of Patent: July 19, 2005Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Yi Li, Zhizhen Zeng, Hla Kyaw, Carrie L. Fischer, Haodong Li, Daniel R. Soppet, Reiner L. Gentz, Ying-Fei Wei, Paul A. Moore, Paul E. Young, John M. Greene, Ann M. Ferrie, Gregg A. Hastings
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Patent number: 6884594Abstract: The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also disclosed are antibodies and fragments thereof that specifically bind to such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the invention.Type: GrantFiled: April 8, 2002Date of Patent: April 26, 2005Assignee: Human Genome Sciences, Inc.Inventors: Daniel R. Soppet, Haodong Li
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Publication number: 20040265894Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.Type: ApplicationFiled: July 20, 2004Publication date: December 30, 2004Applicant: Human Genome Sciences, Inc.Inventors: Daniel R. Soppet, Yi Li, Craig A. Rosen, Steven M. Ruben
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Publication number: 20040254101Abstract: Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.Type: ApplicationFiled: November 12, 2002Publication date: December 16, 2004Applicant: Human Genome Sciences, Inc.Inventors: Patrick J. Dillon, Yi Li, Daniel R. Soppet, Adam Bell, D. R. Duan, Ralph Alderson, Wendy Halpern
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Publication number: 20040253684Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 7, 2004Publication date: December 16, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
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Publication number: 20040241803Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 1, 2004Publication date: December 2, 2004Applicant: Human Genome Sciences, Inc.Inventors: Craig A. Rosen, Jian Ni, Kimberly A. Florence, Michele Fiscella, Ping Wei, Kevin P. Baker, Charles E. Birse, Paul E. Young, George A. Komatsoulis, Paul A. Moore, Daniel R. Soppet
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Patent number: 6824993Abstract: The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer.Type: GrantFiled: October 2, 2001Date of Patent: November 30, 2004Assignee: Human Genome Sciences, Inc.Inventors: Daniel R. Soppet, Yi Li, Craig A. Rosen, Steven M. Ruben
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Publication number: 20040235113Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: June 24, 2004Publication date: November 25, 2004Applicant: Human Genome Sciences, Inc.Inventors: Yanggu Shi, Paul E. Young, Reinhard Ebner, Daniel R. Soppet, Steven M. Ruben
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Patent number: 6806351Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: February 1, 2001Date of Patent: October 19, 2004Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat
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Publication number: 20040185440Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: March 28, 2001Publication date: September 23, 2004Inventors: Ping Feng, Steven M. Ruben, Craig A. Rosen, Reinhard Ebner, Henrik S. Olsen, Jian Ni, Ying-Fei Wei, Daniel R. Soppet, Paul A. Moore, Hla Kyaw, David W. LaFleur, Yanggu Shi, Fouad Janat, Gregory A. Endress, Kenneth C. Carter
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Publication number: 20040152164Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: March 12, 2004Publication date: August 5, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Jian Ni, George Komatsoulis, Craig A. Rosen, Daniel R. Soppet, Yanggu Shi, David W. LaFleur, Henrik Olsen, Reinhard Ebner, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Paul Young
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Publication number: 20040146930Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: March 16, 2004Publication date: July 29, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel R. Soppet, Laurie A. Brewer, Gregory A. Endress, Kenneth C. Carter, Michael Mucenski, Reinhard Ebner, David W. LaFleur, Henrik Olsen, Yanggu Shi, Paul A. Moore, George Komatsoulis
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Publication number: 20040126801Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: December 12, 2003Publication date: July 1, 2004Applicant: Human Genome Sciences, Inc.Inventors: Michele Fiscella, Ping Wei, David W. LaFleur, Henrik S. Olsen, Kevin P. Baker, Reinhard Ebner, George A. Komatsoulis, Craig A. Rosen, Steven M. Ruben, D. Roxanne Duan, Paul E. Young, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Jian Ni, Daniel R. Soppet, Yanggu Shi
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Publication number: 20040126371Abstract: Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the proliferation and differentiation of stem cells of the immune system. Antagonists against such polypeptides are also disclosed. The antagonists include antibodies which may be employed as a therapeutic to treat leukemia and lymphoblastoma, may also be used as imaging agents and diagnostic agents for detecting expression levels of the protein. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.Type: ApplicationFiled: February 3, 2003Publication date: July 1, 2004Applicant: Human Genome Sciences, Inc.Inventors: Yi Li, Daniel R. Soppet
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Publication number: 20040063127Abstract: The present invention relates to a novel hematopoietic signaling factor (HSF) protein which is a member of the cytokine superfamily. In particular, isolated nucleic acid molecules are provided encoding the human HSF protein. HSF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.Type: ApplicationFiled: August 18, 2003Publication date: April 1, 2004Applicant: Human Genome Sciences, Inc.Inventors: Daniel R. Soppet, Steven M. Ruben
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Publication number: 20040048294Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: June 27, 2003Publication date: March 11, 2004Applicant: Human Genome Sciences,Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Roxanne D. Duan, Yanggu Shi, David W. LaFleur, Paul E. Young, Jian Ni, George Komatsoulis, Gregory A. Endress, Daniel R. Soppet
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Publication number: 20040048304Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: September 3, 2003Publication date: March 11, 2004Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Guo-Liang Yu, Paul Young, Ping Feng, Daniel R. Soppet, Ying-Fei Wei, Gregory A. Endress, Roxanne Duan, Hla Kyaw, Reinhard Ebner, David W. LaFleur, Henrik Olsen, Yanggu Shi, Paul A. Moore
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Publication number: 20040044191Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: October 10, 2001Publication date: March 4, 2004Inventors: Carrie L. Fischer, Craig A. Rosen, Daniel R. Soppet, Steven M. Ruben, Hla Kyaw, Yi Li, Zhizhen Zeng, David W. LaFleur, Paul A. Moore, Yanggu Shi, Henrik Olsen, Reinhard Ebner, Charles E. Birse