Patents by Inventor Daniel R. Soppet
Daniel R. Soppet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6590075Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: September 4, 1998Date of Patent: July 8, 2003Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Carrie L. Fischer, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Yanggu Shi
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Publication number: 20030113840Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: February 1, 2002Publication date: June 19, 2003Applicant: Human Genome Sciences, Inc.Inventors: Craig A. Rosen, Jian Ni, Kimberly A. Florence, Michele Fiscella, Ping Wei, Kevin P. Baker, Charles E. Birse, Paul E. Young, George A. Komatsoulis, Paul A. Moore, Daniel R. Soppet
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Publication number: 20030100051Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: September 10, 2001Publication date: May 29, 2003Inventors: Steven M. Ruben, Kimberly A. Florence, Jian Ni, Craig A. Rosen, Kenneth C. Carter, Paul A. Moore, Henrik S. Olsen, Yanggu Shi, Paul E. Young, Ying-Fei Wei, Laurie A. Brewer, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, Charles E. Birse
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Patent number: 6566325Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: July 16, 2001Date of Patent: May 20, 2003Assignee: Human Genome Sciences, Inc.Inventors: Paul A. Moore, Steven M. Ruben, Henrik S. Olsen, Yanggu Shi, Craig A. Rosen, Kimberly A. Florence, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, George Komatsoulis, Roxanne D. Duan
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Publication number: 20030092893Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 20, 2001Publication date: May 15, 2003Applicant: Human Genome Sciences, Inc.Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
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Publication number: 20030092127Abstract: A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor.Type: ApplicationFiled: December 23, 2002Publication date: May 15, 2003Inventors: Daniel R. Soppet, Yi Li, Mark D. Adams
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Publication number: 20030087341Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: January 25, 2002Publication date: May 8, 2003Inventors: Paul A. Moore, Steven M. Ruben, Henrik S. Olsen, Yanggu Shi, Craig A. Rosen, Kimberly A. Florence, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, George Komatsoulis, Roxanne D. Duan
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Publication number: 20030077809Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: June 28, 2001Publication date: April 24, 2003Inventors: Steven M. Ruben, Kimberly Florence, Jian Ni, Craig A. Rosen, Kenneth C. Carter, Paul A. Moore, Henrik Olsen, Yanggu Shi, Paul Young, Ying-Fei Wei, Laurie A. Brewer, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner
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Publication number: 20030078405Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: July 2, 2001Publication date: April 24, 2003Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
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Patent number: 6548539Abstract: Compounds of the general structure according to Formula (I) wherein R1 is selected from alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl; R2 is selected from alkyl, alkenyl, alkyny, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; R3 is selected from aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; W is selected from Ch2, O and S; n is 0 to about 3: X is selected from S or O; Y, if present, is selected from a bond, aryl, NH, NR, O or S, where R3 is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl; and Z, if present, can represent a bond or is selected from lower alkyl, O or S are disclosed. Also disclosed are uses of such compounds for treating a variety of disease conditions, including cancer.Type: GrantFiled: March 5, 2002Date of Patent: April 15, 2003Assignee: Avalon PharmaceuticalsInventors: Stanislaw Pikul, Daniel R. Soppet, Paul E. Young
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Publication number: 20030069408Abstract: The present invention relates to novel Nodal and Lefty proteins which are members of the TGF-&bgr; family. In particular, isolated nucleic acid molecules are provided encoding the human Nodal and Lefty proteins. Nodal and Lefty polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Nodal and Lefty activity. Also provided are diagnostic methods for detecting cell growth and differentiation-related disorders and therapeutic methods for treating cell growth and differentiation-related disorders.Type: ApplicationFiled: June 11, 2002Publication date: April 10, 2003Applicant: Human Genome Sciences, Inc.Inventors: Reinhard Ebner, Daniel R. Soppet, Steven M. Ruben
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Publication number: 20030069405Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: May 15, 2002Publication date: April 10, 2003Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Paul E. Young, Laurie A. Brewer, Reinhard Ebner, Henrik S. Olsen, Kimberly A. Florence, Craig A. Rosen, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Charles Florence, Daniel R. Soppet, Gregory A. Endress, Ping Feng, George A. Komatsoulis
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Publication number: 20030064412Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: October 30, 2001Publication date: April 3, 2003Inventors: Carrie L. Fischer, Craig A. Rosen, Daniel R. Soppet, Steven M. Ruben, Hla Kyaw, Yi Li, Zhizhen Zeng, David W. LaFleur, Paul A. Moore, Yanggu Shi, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer
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Publication number: 20030065151Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: April 4, 2002Publication date: April 3, 2003Applicant: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Jian Ni, Craig A. Rosen, Ying-Fei Wei, Paul Young, Kimberly Florence, Daniel R. Soppet, Laurie A. Brewer, Gregory A. Endress, Kenneth C. Carter, Michael Mucenski, Reinhard Ebner, David W. LaFleur, Henrik Olsen, Yanggu Shi, Paul A. Moore, George Komatsoulis
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Publication number: 20030065160Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 7, 2001Publication date: April 3, 2003Applicant: Human Genome Sciences, Inc.Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
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Patent number: 6537539Abstract: Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the proliferation and differentiation of stem cells of the immune system. Antagonists against such polypeptides are also disclosed. The antagonists include antibodies which may be employed as a therapeutic to treat leukemia and lymphoblastoma, may also be used as imaging agents and diagnostic agents for detecting expression levels of the protein. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.Type: GrantFiled: February 17, 1999Date of Patent: March 25, 2003Assignee: Human Genome Sciences, Inc.Inventors: Yi Li, Daniel R. Soppet
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Publication number: 20030055236Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: March 14, 2002Publication date: March 20, 2003Applicant: Human Genome Sciences, Inc.Inventors: Paul A. Moore, Steven M. Ruben, Kenneth C. Carter, Yanggu Shi, Craig A. Rosen, Daniel R. Soppet, Hla Kyaw, Ying-Feig Wei, Kimberly A. Florence, D. Roxanne Duan, Charles Florence, John M. Greene, Ping Feng, Ann M. Ferrie, Guo-Liang Yu, Fouad Janat, Jian Ni
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Publication number: 20030054443Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: October 4, 2001Publication date: March 20, 2003Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat, Charles E. Birse
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Patent number: 6534631Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: GrantFiled: January 13, 2000Date of Patent: March 18, 2003Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, George Komatsoulis, Roxanne D. Duan, Craig A. Rosen, Paul A. Moore, Yanggu Shi, David W. LaFleur, Reinhard Ebner, Henrik Olsen, Laurie A. Brewer, Kimberly A. Florence, Paul Young, Michael Mucenski, Gregory A. Endress, Daniel R. Soppet
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Publication number: 20030049618Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.Type: ApplicationFiled: March 16, 2001Publication date: March 13, 2003Inventors: Steven M. Ruben, Craig A. Rosen, Daniel R. Soppet, Kenneth C. Carter, Daniel P. Bednarik, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul E. Young, John M. Greene, Ann M. Ferrie, D. Roxanne Duan, Jing-Shan Hu, Kimberly A. Florence, Henrik S. Olsen, Carrie L. Fischer, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, David W. LaFleur, Yi Li, Zhizhen Zeng, Hla Kyaw