Abstract: Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists of 1, 2 or 3 C2-set Ig-like domain(s) e.g., C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. Also provided herein are compositions including a) an immune cell expressing a CAR, wherein the CAR is specific for a tag and b) a tagged polypeptide.

Abstract: Systems, devices and methods for managing mobile assets at a worksite. A system computer creates a geofence relating to the geolocation of a first communication device disposed in a first mobile asset, the data points of the geofence periodically updated according to the geolocation of the first communication device such that changes in the geolocation of the first communication device are proportionally reflected in the updated geolocation of the datapoints of the geofence. The cycle time of a second communication device disposed in a second mobile asset can be determined by determining the amount of time lapsed after the second communication device triggers the geofence. Various triggering events are described. Various shapes of the geofence are described to avoid unintended triggers of the geofence by assets, including polygonal shapes.

Abstract: A method of analyzing a composite structure for damage tolerance. The method includes obtaining a structural configuration and determining at least one metric of interest for the structural configuration. A dent depth meta-model is developed based on the structural configuration, the at least one metric of interest, and information obtained from a machine learning algorithm. The at least one metric of interest provides a constraint for the dent depth meta-model and the machine learning algorithm is trained based on a historical physical test dataset of a plurality of composite components. The dent depth meta-model is utilized to estimate an impact energy to establish a threshold dent depth in the structural configuration. A computer-based simulation is performed with the structural configuration utilizing the impact energy from the dent depth meta-model. At least one design value is determined for the structural configuration based on output data generated from the computer-based simulation.

Abstract: Methods of designing a structure taking into account thermal loads are presented. A method to analyze thermal build-up in a joint is presented. Physical testing between a first material and a second material is performed to determine physical data comprising at least one of stiffness, strain, load, and displacement. The physical data is analyzed. A closed form equation is generated based on the analysis to calculate the thermal build-up in the joint.

Abstract: One variation of a modular keyboard system includes a chassis; a keyboard module; and a trackpad module. The chassis includes a controller and an input deck. The input deck includes an array of couplers, each coupler in the array of couplers including a magnetic element and an electronic communication port. The keyboard module includes a first connector configured electronically and magnetically couple a first coupler, in the array of couplers, to transiently retain the keyboard module in a first configuration spanning an upper region of the input deck and transmit electrical signals from a set of keys to the controller. The trackpad module includes a second connector configured to electronically and magnetically couple a second coupler, in the array of couplers, to transiently retain the trackpad module in a second configuration spanning a lower region of the input deck and transmit electrical signals from a touch sensor to the controller.

Abstract: Systems, devices and methods for managing mobile assets at a worksite. A system computer creates a geofence relating to the geolocation of a first communication device disposed in a first mobile asset, the data points of the geofence periodically updated according to the geolocation of the first communication device such that changes in the geolocation of the first communication device are proportionally reflected in the updated geolocation of the datapoints of the geofence. The cycle time of a second communication device disposed in a second mobile asset can be determined by determining the amount of time lapsed after the second communication device triggers the geofence. Various triggering events are described. Various shapes of the geofence are described to avoid unintended triggers of the geofence by assets, including polygonal shapes.

Abstract: Systems, devices and methods for managing mobile assets at a worksite. A system computer creates a geofence relating to the geolocation of a first communication device disposed in a first mobile asset, the data points of the geofence periodically updated according to the geolocation of the first communication device such that changes in the geolocation of the first communication device are proportionally reflected in the updated geolocation of the datapoints of the geofence. The cycle time of a second communication device disposed in a second mobile asset can be determined by determining the amount of time lapsed after the second communication device triggers the geofence. Various triggering events are described. Various shapes of the geofence are described to avoid unintended triggers of the geofence by assets, including polygonal shapes.

Abstract: The present invention provides a CAR comprising a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein said spacer consists of 1, 2 or 3 C2-set Ig-like domain(s). Said C2-set Ig-like domain(s) may be selected from the group of C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. A composition comprising a) an immune cell expressing said CAR, wherein said CAR is specific for a tag and b) a tagged polypeptide is also disclosed.

Abstract: Systems, devices and methods for managing mobile assets at a worksite. A system computer creates a geofence relating to the geolocation of a first communication device disposed in a first mobile asset, the data points of the geofence periodically updated according to the geolocation of the first communication device such that changes in the geolocation of the first communication device are proportionally reflected in the updated geolocation of the datapoints of the geofence. The cycle time of a second communication device disposed in a second mobile asset can be determined by determining the amount of time lapsed after the second communication device triggers the geofence. Various triggering events are described. Various shapes of the geofence are described to avoid unintended triggers of the geofence by assets, including polygonal shapes.

Abstract: A countercurrent heat recovery ventilation system includes an air module assembly and heat exchanger assembly. Air module assembly made from front and back panels connected by two side panels, base plate fixed with the side panels and placed parallel between side panels and a double side radial impeller with a shaft, an electric drive form two hydraulically isolated flow canals with inlet and outlet openings. The heat exchanger assembly comprises a heat-exchanger that could be done as changeable flow side heat-exchanger made as folded corrugated fins or plates, thus each of the both flow passages split in separate flow channels. Every other channel is sealed to flow from flow same direction forcing the flow to be in opposite direction in all adjacent cannels. This forms two hydraulically isolated flow passages with intake and outtake openings connected respectively with outlet and inlet openings of the air blower assembly.

Abstract: Certain example embodiments relate to a system (1) for handling performance issues of a production Complex Event Processing, CEP, system (2) during runtime. The production CEP system (2) includes at least one event source, at least one continuous query and at least one event sink. The system (1) includes: at least one monitoring sensor for producing a stream of status events relating to the production CEP system (2); and a monitoring CEP system (10) for executing at least one continuous analysis query on the stream of status events to produce a stream of monitoring events. The stream of monitoring events indicates performance issues of the production CEP system (2) relating to the throughput, the latency, and/or the memory consumption of the production CEP system (2).

Abstract: Certain example embodiments relate to techniques for investigating event streams in complex event processing (CEP) environments. Input events from one or more input event streams and query registration-related events from a registration event stream are received. Query registration-related events are associated with actions taken with respect to queries performed on the input event stream(s). Event-based profiles are developed by subjecting the received input events to a profiling CEP engine. Event-based profiles include data mining related and/or statistical characteristics for each input event stream. Query-based profiles are developed by subjecting the received query registration-related events to the CEP engine. Query-based profiles include data indicative of how relevant the queries performed on the input event stream(s) are and/or how those queries are relevant to the input event stream(s) on which they are performed.

Abstract: The invention is directed to a heating block (100) for a continuous flow heater in which a water flow system with channels is arranged in the heating block (100). A heating path (300) of the water flow system forms a hottest channel (340) with a hottest heating element (341) during operation of the continuous flow heater. The hottest channel (340) is arranged downstream of at least one channel (310, 320, 330) of the heating path (300) in a flow direction (110). The hottest channel (340) of the heating path (300) is surrounded by at least four channels which are located between an outer surface (120) of the heating block (100) and the hottest channel (340). Accordingly, the hottest channel (340) of the continuous flow heater is surrounded by at least four channels and is shielded relative to an air space (160).

Abstract: Certain example embodiments address issues associated with erroneous events produced in Complex Event Processing (CEP) applications. An error handler is controlled to at least: receive, via an event bus, events from external input event sources; receive, via the event bus, error events from an application configured to process events received from the event bus, and to provide to the event bus results obtained from processing received events, and error events corresponding to errors detected at its input and/or processing layer(s); generate, for a given error, an error analysis event and an error impact event by executing a CEP query on at least a corresponding received error event; and provide to the event bus generated error analysis events and generated error impact events. Error analysis events describe for administrators detailed information analyzing corresponding errors. Error impact events describe for business users impacts corresponding errors have for their business user applications.

Abstract: Certain example embodiments address issues associated with erroneous events produced in Complex Event Processing (CEP) applications. An error handler is controlled to at least: receive, via an event bus, events from external input event sources; receive, via the event bus, error events from an application configured to process events received from the event bus, and to provide to the event bus results obtained from processing received events, and error events corresponding to errors detected at its input and/or processing layer(s); generate, for a given error, an error analysis event and an error impact event by executing a CEP query on at least a corresponding received error event; and provide to the event bus generated error analysis events and generated error impact events. Error analysis events describe for administrators detailed information analyzing corresponding errors. Error impact events describe for business users impacts corresponding errors have for their business user applications.

Abstract: Certain example embodiments relate to techniques for investigating event streams in complex event processing (CEP) environments. Input events from one or more input event streams and query registration-related events from a registration event stream are received. Query registration-related events are associated with actions taken with respect to queries performed on the input event stream(s). Event-based profiles are developed by subjecting the received input events to a profiling CEP engine. Event-based profiles include data mining related and/or statistical characteristics for each input event stream. Query-based profiles are developed by subjecting the received query registration-related events to the CEP engine. Query-based profiles include data indicative of how relevant the queries performed on the input event stream(s) are and/or how those queries are relevant to the input event stream(s) on which they are performed.

Abstract: Certain example embodiments relate to a system (1) for handling performance issues of a production Complex Event Processing, CEP, system (2) during runtime. The production CEP system (2) includes at least one event source, at least one continuous query and at least one event sink. The system (1) includes: at least one monitoring sensor for producing a stream of status events relating to the production CEP system (2); and a monitoring CEP system (10) for executing at least one continuous analysis query on the stream of status events to produce a stream of monitoring events. The stream of monitoring events indicates performance issues of the production CEP system (2) relating to the throughput, the latency, and/or the memory consumption of the production CEP system (2).

Abstract: A wound transformer core is provided with at least one core loop made of a magnetic material. The transformer core includes multiple thin amorphous band-like iron sheets which are concentrically stacked around at least one center axis. A lower yoke section, an upper yoke section, and at least two limb sections are formed. The transformer core includes a modular plate-like support structure which is affixed upright to the center axis on both face sides of the lower yoke section and on both face sides of each limb section such that neighbored iron sheets are affixed together at their outer edge. The modular plate-like support structure includes, for each face side of the corresponding core sections, at least two plate-like modules, which are each connected to each other by a first or second plug-in connection.

Abstract: A wound transformer core is provided with at least one core loop made of a magnetic material. The transformer core includes multiple thin amorphous band-like iron sheets which are concentrically stacked around at least one center axis. A lower yoke section, an upper yoke section, and at least two limb sections are formed. The transformer core includes a modular plate-like support structure which is affixed upright to the center axis on both face sides of the lower yoke section and on both face sides of each limb section such that neighbored iron sheets are affixed together at their outer edge. The modular plate-like support structure includes, for each face side of the corresponding core sections, at least two plate-like modules, which are each connected to each other by a first or second plug-in connection.

Abstract: The present invention relates to a dispersion at least comprising particles comprising at least one magnetic iron oxide as component A and a solvent mixture as component B comprising (B1) 5% to 95% by weight of at least one water-miscible organic solvent LM as component B1 and (B2) 5% to 95% by weight of water as component B2, the sum of components B1 and B2 making 100% by weight, and to a method for producing a dispersion of this kind, comprising at least the steps (I) mixing particles comprising at least one magnetic iron oxide with at least one water-miscible organic solvent LM and water, (II) homogenizing the mixture from step (I), where a shearing energy of at least 2 kW/m3 is introduced into the mixture in step (II).