Patents by Inventor Daniel Simons

Daniel Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imaging guided ambient ionisation mass spectrometry
    Patent number: 10978284
    Abstract: A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 13, 2021
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Michael Raymond Morris, Julia Balog, Emrys Jones, Keith Richardson, James Ian Langridge, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • DEVICE, IN PARTICULAR MACHINE, FOR PRODUCING A WIEGAND WIRE FROM A WIRE, IN PARTICULAR A PULSE WIRE, AND METHOD FOR OPERATING A DEVICE
    Publication number: 20210101202
    Abstract: In a device, in particular machine, for producing Wiegand wire from a wire, in particular pulse wire, and a method for operating a device, the device having a first clamping chuck, a second clamping chuck, and a third clamping chuck, the wire being fed through each of the three clamping chucks, in particular so that the wire is able to be connected in a releasable and torsionally fixed manner to the three clamping chucks, in particular able to be connected to the three clamping chucks in a releasable, torsionally fixed and nonpositive manner. The clamping chucks are set apart from one another in the wire direction, and the second clamping chuck is situated between the first and the third clamping chuck in the wire direction.
    Type: Application
    Filed: March 1, 2018
    Publication date: April 8, 2021
    Applicant: SEW-EURODRIVE GMBH & CO. KG
    Inventors: Olaf SIMON, Dennis RÄDLE, Julian HOFFMANN, Daniel Simon FUCHS
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10971346
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: April 6, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10916415
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: February 9, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10910206
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: February 2, 2021
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • AXL-SPECIFIC ANTIBODY-DRUG CONJUGATES FOR CANCER TREATMENT
    Publication number: 20200397913
    Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of resistant or refractory cancers.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 24, 2020
    Inventors: Julia BOSHUIZEN, Kirstine JACOBSEN, Esther BREIJ, Louise KOOPMAN, David SATIJN, Edward VAN DEN BRINK, Dennis VERZIJL, Rob DE JONG, Riemke VAN DIJKHUIZEN RADERSMA, Daniel Simon PEEPER, Henrik Jørn DITZEL, Paul PARREN
  • Method for producing a current collector for a fuel cell, and fuel cell
    Patent number: 10862137
    Abstract: The invention relates to a method for producing a current collector (1) for a fuel cell. The method comprises the following steps: mixing a power-type or granulate-type base material (2) with a binding agent (3) and with fibres (4) in order to generate a material mixture (5), wherein the fibres (4) have a lower melting point and/or a lower chemical resistance than the base material (2); moulding a moulded body (6) from the material mixture (5); debinding the binding agent (3) from the moulded body (6); removing at least one portion of the fibres (4) from the moulded body (6); and sintering the moulded body (6). The invention also relates to a fuel cell having a current collector (1) that is produced by means of a method according to the invention.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: December 8, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Andreas Burghardt, Arne Huber, Daniel Simon, Jens Burghaus, Juergen Oberle, Witold Pieper, Maxim Smirnov
  • Ionisation of gaseous samples
    Patent number: 10840076
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: November 17, 2020
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Image processing system for eliminating or reducing streak artifacts in rotational imaging
    Patent number: 10803632
    Abstract: An image processing system, comprising an input port (IN) for receiving a projection image of an object. The image is acquired by a rotational image apparatus (IM) at a position on an imaging trajectory in an adjustable rotation plane (?) around an imaging region. An image artifact extent predictor (AP) of the system is configured to predict for said image a projection area of a reconstruction artifact. A visualizer (VIZ) is configured to visualize, on a display unit (MT), said image with a visual indication of the projection area.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: October 13, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Daniël Simon Anna Ruijters, Thijs Grunhagen
  • Ionisation of gaseous samples
    Patent number: 10784096
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 22, 2020
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Capacitively coupled REIMS technique and optically transparent counter electrode
    Patent number: 10777399
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish (4) and contacting e.g. the rear surface of the insulating substrate with a first electrode (9). The method further comprises contacting the sample with a second electrode (2) and applying an AC or RF voltage to the first and second electrodes (9,2) in order to generate an aerosol from the sample.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 15, 2020
    Assignee: Micromass UK Limited
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
    Patent number: 10777397
    Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 15, 2020
    Assignee: Micromass UK Limited
    Inventors: Zoltán Takáts, Júlia Balog, Steven Derek Pringle, Tamás Karancsi, Michael Raymond Morris, Lajos Gödörhazy, Dániel Szalay, Dániel Simon
  • CLASSIFICATION AND PROGNOSIS OF CANCER
    Publication number: 20200263255
    Abstract: The present invention relates to the classification of cancers, in particular prostate cancers, using samples from patients. In particular, the invention provides methods for identifying potentially aggressive prostate cancers to determine which cancers are or will become aggressive (and hence require treatment) and which will remain indolent (and will therefore not require treatment). The present invention is therefore useful to identify patients with a poor prognosis. The specific population of cancer identified by the present invention is referred to herein as DESNT cancer. The invention also provides biomarker panels useful in the diagnosis and prognosis of cancer.
    Type: Application
    Filed: October 5, 2017
    Publication date: August 20, 2020
    Inventors: Bogdan-Alexandru Luca, Vincent Moultion, Daniel Simon Brewer, Colin Stephen Cooper
  • Collision Surface for Improved Ionisation
    Publication number: 20200258729
    Abstract: An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil- shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.
    Type: Application
    Filed: April 29, 2020
    Publication date: August 13, 2020
    Inventors: Tamas KARANCSI, Daniel SIMON, Lajos GODORHAZY, Daniel SZALAY, Steven Derek PRINGLE, Emrys JONES, Ian TRIVETT, Stephen O'BRIEN, Anthony HESSE, Matt HENDERSON, Alvin CHUA, Zoltan TAKÁTS
  • Liquid trap or separator for electrosurgical applications
    Patent number: 10679836
    Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 9, 2020
    Assignee: Micromass UK Limited
    Inventors: Tamas Karancsi, Lajos Godorhazy, Daniel Szalay, Zoltan Takats, Julia Balog, Steven Derek Pringle, Daniel Simon
  • CAPACITIVELY COUPLED REIMS TECHNIQUE AND OPTICALLY TRANSPARENT COUNTER ELECTRODE
    Publication number: 20200168445
    Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.
    Type: Application
    Filed: January 31, 2020
    Publication date: May 28, 2020
    Inventors: Steven Derek Pringle, Lajos Godorhazy, Daniel Simon, Daniel Szalay, Zoltan Takats, Tamas Karancsi
  • Methods and systems for delivering an implant
    Patent number: 10639181
    Abstract: A system for delivering an implant including a handle, a trigger, an actuation assembly, and a catheter assembly. The actuation assembly is configured to displace the outer tubular member in the proximal direction and to separately move the inner shaft member distally upon deployment of the trigger from the first position to the second position, and move the inner shaft member proximally with no displacement of the outer tubular member upon return of the trigger from the second position to the first position. The catheter assembly includes an outer tubular member, an inner shaft member, and a pusher assembly.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: May 5, 2020
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Daniel H. Shumer, Ronald G. Earles, Nianjiong J. Bei, Barbara Stamberg, Daniel Simon, Maria Del Rosario Nava, Michael L. Green, Matthew J. Gillick
  • Refusal-based methods of establishing a cat or dog food preference
    Patent number: 10613070
    Abstract: Refusal-based methods of establishing a cat or dog food preference, which can include methods of selecting a preferred cat or dog food among multiple foods as well as methods of determining palatability are provided. The methods can include presenting a cat or dog with one or more small samples of a test food and observing for refusal behavior, which can include refusing to eat a food sample. Higher numbers of instances of refusal of a particular food can be correlated with lower palatability.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: April 7, 2020
    Assignee: MARS, INCORPORATED
    Inventors: Franck Peron, Oliver Henry Piers Burman, Daniel Simon Mills, Matthew Williams
  • ISO-CENTERING IN C-ARM COMPUTER TOMOGRAPHY
    Publication number: 20200093447
    Abstract: The present invention relates to iso-centering an object of interest prior to computer tomography (CT) scanning for examination of a patient in a C-arm CT examination apparatus. In order to provide facilitated positioning and to overcome or at least minimize these drawbacks, a C-arm CT examination apparatus (10) for CT scanning for examination of a patient is provided. The apparatus comprises a patient support unit, an acquisition unit, a data processing and control unit, and a display unit. The patient support unit is configured to bed a patient, free of motion, on the patient support. The acquisition unit is configured to acquire scout images of the patient including the object of interest in a respective position of the apparatus having position parameters.
    Type: Application
    Filed: January 29, 2018
    Publication date: March 26, 2020
    Inventors: DANIEL SIMON ANNA RUIJTERS, FRED SIMON BEREND VAN NIJNATTEN, JAVIER OLIVAN BESCOS, RONALDUS PETRUS JOHANNES HERMANS, ADRIE BASELMANS, INA KLEIN TEESELINK, JEROEN GERARD SCHEEPENS, WALTER EVERARD CARELS, THIJS GRUNHAGEN
  • INLET INSTRUMENTATION FOR ION ANALYSER COUPLED TO RAPID EVAPORATIVE IONISATION MASS SPECTROMETRY ("REIMS") DEVICE
    Publication number: 20200075301
    Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
    Type: Application
    Filed: October 31, 2019
    Publication date: March 5, 2020
    Inventors: Zoltán TAKÁTS, Júlia BALOG, Steven Derek PRINGLE, Tamás KARANCSI, Michael Raymond MORRIS, Lajos GÖDÖRHÁZY, Dániel SZALAY, Dániel SIMON