Patents by Inventor Daniel Sobek

Daniel Sobek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10420469
    Abstract: A non-invasive system and method. Sample light is delivered into an anatomical structure, such that a portion of the sample light passes through a target voxel comprising brain matter in the head and is scattered by the head as signal light. The signal light is detected, changes in the level of water concentration or relative water concentration of the target voxel are detected based on the detected signal light, and a level of neural activity is determined within the target voxel based on the determined changes level of the water concentration or relative water concentration of the target voxel.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 24, 2019
    Assignee: HI LLC
    Inventors: Daniel Sobek, Changhuei Yang, Adam Marblestone, Jamu Alford
  • Patent number: 10299682
    Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Multiple pulses of the sample light are delivered into the anatomical structure for each pulse of the ultrasound delivered into the target voxel. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate different interference light patterns, which are detected.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: May 28, 2019
    Assignee: HI LLC
    Inventors: Changhuei Yang, Adam Marblestone, Jamu Alford, Daniel Sobek
  • Publication number: 20190150745
    Abstract: A non-invasive system and method. Sample light is delivered into an anatomical structure, such that a portion of the sample light passes through a target voxel comprising brain matter in the head and is scattered by the head as signal light. The signal light is detected, changes in the level of water concentration or relative water concentration of the target voxel are detected based on the detected signal light, and a level of neural activity is determined within the target voxel based on the determined changes level of the water concentration or relative water concentration of the target voxel.
    Type: Application
    Filed: December 15, 2017
    Publication date: May 23, 2019
    Applicant: HI LLC
    Inventors: Daniel Sobek, Changhuei Yang, Adam Marblestone, Jamu Alford
  • Publication number: 20190150744
    Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Multiple pulses of the sample light are delivered into the anatomical structure for each pulse of the ultrasound delivered into the target voxel. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate different interference light patterns, which are detected.
    Type: Application
    Filed: December 15, 2017
    Publication date: May 23, 2019
    Applicant: HI LLC
    Inventors: Changhuei Yang, Adam Marblestone, Jamu Alford, Daniel Sobek
  • Publication number: 20190150751
    Abstract: An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.
    Type: Application
    Filed: March 29, 2018
    Publication date: May 23, 2019
    Applicant: HI LLC
    Inventors: Changhuei Yang, Adam Marblestone, Jamu Alford, Daniel Sobek
  • Patent number: 10016137
    Abstract: An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: July 10, 2018
    Assignee: HI LLC
    Inventors: Changhuei Yang, Adam Marblestone, Jamu Alford, Daniel Sobek, Christian Wentz
  • Patent number: 9227189
    Abstract: A microfluidic liquid stream configuration system is provided including providing a substrate; forming a first co-planar electrode and a second co-planar electrode on the substrate; applying a dielectric layer, with a controlled surface energy, on the first co-planar electrode and the second co-planar electrode; forming an input reservoir on the first co-planar electrode and a second co-planar electrode; supplying a liquid in the input reservoir for analysis; and imposing an electric field, an electric field gradient, or a combination thereof on the liquid for respectively driving surface charge or dipole moments in the liquid for configuring a liquid stream.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: January 5, 2016
    Assignee: Zymera, Inc.
    Inventors: Daniel Sobek, Jun Zeng
  • Patent number: 9091659
    Abstract: A qualitative and quantitative hydrolase detection method includes providing a caged coelenterazine molecule having a detection molecule bonded between a first bonding site or a second bonding site of a coelenterazine molecule and a steric caging group; activating an uncaged coelenterazine molecule by cleaving the detection molecule in the caged coelenterazine molecule with a hydrolase enzyme; determining a light emission from a coelenterazine-activated bioluminescent enzyme reacting with the uncaged coelenterazine molecule activated in the presence of the hydrolase enzyme; and correlating the light emission for quantitatively and qualitatively determining the presence of the hydrolase enzyme.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: July 28, 2015
    Assignee: Zymera, Inc.
    Inventors: Sukanta Bhattacharyya, Daniel Sobek
  • Publication number: 20140011225
    Abstract: An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecule from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Inventors: Sukanta Bhattacharyya, Daniel Sobek
  • Patent number: 8530178
    Abstract: An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecule from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: September 10, 2013
    Assignee: Zymera, Inc.
    Inventors: Daniel Sobek, Jianghong Rao
  • Patent number: 7704360
    Abstract: Devices and methods for separating sample constituents are provided. The subject devices are characterized by having a fluid flow path with at least one electrophoretic separation element positioned at a region thereof. The separation element includes an element for applying an electric field across the fluid flow path and a trapping element for trapping sample constituents that migrate out of the flow path when an electric field is applied across the fluid flow path. In using the subject devices, sample is moved past the separation element and an electric field is applied across the flow path such that constituents of the sample migrate into the trapping element. The subject devices and methods find use in a variety of applications, including protein separation applications.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: April 27, 2010
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel Sobek, Christian A. Heid
  • Publication number: 20100068741
    Abstract: An assay method includes providing a luminescent nanocrystal; combining a solution having an adenosine triphosphate molecule; and displaying a light emission by the luminescent nanocrystal and the solution combined.
    Type: Application
    Filed: October 17, 2007
    Publication date: March 18, 2010
    Applicant: ZYMERA, INC.
    Inventors: Daniel Sobek, Jianghong Rao
  • Publication number: 20100055725
    Abstract: An assay system (300) comprising providing a platform (102) having a contact surface (104); immobilizing an amino acid group (108), having an amine side group (109), on the contact surface (104); transforming the amine side group (109), in the amino acid group (108) to a ketone group (120); and reacting an indicator (122) with the ketone group (120) for displaying a light emission (128) from the indicator (122).
    Type: Application
    Filed: October 17, 2007
    Publication date: March 4, 2010
    Applicant: ZYMERA, INC.
    Inventors: Jianghong Rao, Daniel Sobek
  • Publication number: 20100035290
    Abstract: An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecules from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.
    Type: Application
    Filed: October 17, 2007
    Publication date: February 11, 2010
    Applicant: ZYMERA, INC.
    Inventors: Daniel Sobek, Jianghong Rao
  • Publication number: 20090269243
    Abstract: An electrically controlled microfluidic system (1300) is provided including: providing a probe fluid (128) extending longitudinally; restricting a longitudinal movement of the probe fluid (128) by capillary effects; moving the probe fluid (128) longitudinally using an electric field, an electric field gradient, or a combination thereof; reacting a fluid under test (130) with the probe fluid (128) to start a reacting mixture; and measuring the reacting mixture over distance, time, or a combination thereof.
    Type: Application
    Filed: January 28, 2005
    Publication date: October 29, 2009
    Applicant: ZYMERA, INC.
    Inventor: Daniel Sobek
  • Publication number: 20080251383
    Abstract: A microfluidic liquid stream configuration system is provided including providing a substrate; forming a first co-planar electrode and a second co-planar electrode on the substrate; applying a dielectric layer, with a controlled surface energy, on the first co-planar electrode and the second co-planar electrode; forming an input reservoir on the first co-planar electrode and a second co-planar electrode; supplying a liquid in the input reservoir for analysis; and imposing an electric field, an electric field gradient, or a combination thereof on the liquid for respectively driving surface charge or dipole moments in the liquid for configuring a liquid stream.
    Type: Application
    Filed: August 23, 2006
    Publication date: October 16, 2008
    Applicant: Zymera, Inc.
    Inventors: Daniel Sobek, Jun Zeng
  • Patent number: 7372023
    Abstract: An ion source for an analytical instrument is described. The ion source comprises a capillary tip and counter-electrode interface and a feedback loop control device connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier, a DC de-coupler, a frequency to voltage converter, a controller, and a voltage-controlled high-voltage power supply that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: May 13, 2008
    Assignee: Agilent Technologies, Inc.
    Inventors: Daniel Sobek, Jing Cai, Kevin Killeen, Hongfeng Yin
  • Patent number: 7173240
    Abstract: An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: February 6, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Karen L. Seaward, Hongfeng Yin, Kevin P. Killeen, Daniel Sobek, Daniel Roitman
  • Patent number: 7138062
    Abstract: The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: November 21, 2006
    Assignee: Agilent Technologies, Inc.
    Inventors: Hongfeng Yin, Kevin Killeen, Daniel Sobek
  • Patent number: 7125763
    Abstract: A process of fabricating a memory cell that includes a substrate that has a first region and a second region with a channel therebetween by forming a gate above the channel of the substrate, forming a bitline and siliciding the bitline.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: October 24, 2006
    Assignee: Spansion LLC
    Inventors: Daniel Sobek, Timothy J. Thurgate, Mark W. Randolph