Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products for presenting display content on a display of a computing system. A method includes selecting, from a collection of luminance profiles that are each configured to reduce brightness of the display content in different manners, a first luminance profile based on the current display brightness setting, the first luminance profile specifying a first amount of brightness reduction to a peripheral portion of the display content and a first gradient of brightness reduction for a portion of the display content between the peripheral portion of the display content and a center portion of the display content; applying the first luminance profile to the display content to modify the display content by reducing a brightness of the display content according to the first luminance profile; and presenting the display content on the display.

Abstract: A method of detecting a small area wildfire is described. The method includes: (i) receiving, at a processor, an electronic map of an area of interest; (ii) receiving, at the processor from a satellite, location information for a high-altitude balloon disposed above the area of interest; (iii) determining, using the processor and based one or more different types of sensor data that is received from one or more different types of sensors on the high-altitude balloon and the high-altitude balloon location, one or more wildfire locations; (iv) embedding each of the wildfire locations on the electronic map to produce a fire activity map; and (v) causing to display or displaying the fire activity map including the wildfire locations within the area of interest.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products for presenting display content on a display of a computing system. A method includes selecting, from a collection of luminance profiles (308) that are each configured to reduce brightness of the display content in different manners, a first luminance profile based on the current display brightness setting (320), the first luminance profile specifying a first amount of brightness reduction to a peripheral portion of the display content and a first gradient of brightness reduction for a portion of the display content between the peripheral portion of the display content and a center portion of the display content; applying the first luminance profile to the display content to modify the display content by reducing a brightness of the display content according to the first luminance profile; and presenting the display content on the display.

Abstract: A method can include determining that a first frame for display on an emissive display meets a low encoded intensity condition; based on the determination that the first frame meets the low encoded intensity condition, disabling refresh rate transitions when displaying multiple frames on the emissive display; while the refresh rate transitions are disabled, maintaining a refresh rate while changing a graphic intensity; determining that a second frame does not meet the low encoded intensity condition; based on the determination that the second frame does not meet the low encoded intensity condition, enabling refresh rate transitions when displaying multiple frames on the emissive display; and while the refresh rate transitions are enabled, changing the refresh rate for the emissive display based on the graphic intensity changing.

Abstract: A method includes: (a) receiving initial image frame data to display an image frame on a display panel, a luminance of each pixel of the display corresponding to a gray level; (b) identifying dark pixels at or below a first threshold gray level; (c) identifying pixels to be modified as a subset of the dark pixels neighbored by at least one bright pixel exceeding a second threshold gray level; (d) increasing by an incremental amount the gray level of the pixels to be modified, providing modified image frame data composed of: (i) the dark pixels that are neighbored by at least one bright pixel having gray levels that have been increased by the incremental gray level amount, and (ii) other pixels that have gray levels from the initial image frame data; and (e) displaying the image frame using the modified image frame data.

Abstract: The disclosure provides, in various embodiments, polypeptides that upon administration to a mammalian subject, elicit a reduced immunogenicity in the subject, relative to a bacterial asparaginase. The disclosure also provides, in various embodiments, fusion proteins comprising one or more of the polypeptides, polynucleotides encoding the polypeptides, vectors and host cells suitable for expressing the polypeptides, methods for treating a disease (e.g., cancer) in mammalian subject (e.g., a human), and methods for reducing a level of asparagine or asparagine-containing product in a biological fluid from a mammalian subject.

Abstract: A method includes: (a) receiving initial image frame data to display an image frame on a display panel, a luminance of each pixel of the display corresponding to a gray level; (b) identifying dark pixels at or below a first threshold gray level; (c) identifying pixels to be modified as a subset of the dark pixels neighbored by at least one bright pixel exceeding a second threshold gray level; (d) increasing by an incremental amount the gray level of the pixels to be modified, providing modified image frame data composed of: (i) the dark pixels that are neighbored by at least one bright pixel having gray levels that have been increased by the incremental gray level amount, and (ii) other pixels that have gray levels from the initial image frame data; and (e) displaying the image frame using the modified image frame data.

Abstract: This document describes techniques and apparatuses for performing color calibration of display modules using a reduced number of display characteristic measurements. In aspects, methods include generating a measured lookup table (50) for a source display module (32), using dynamic optimization to down-sample the measured lookup table and select a set of color patches, sending the color patches to a testing display module; measuring output values for the testing display module; generating a sparse lookup table (52) relating the color patches and the measured output values, up-sampling the sparse lookup table to a forward lookup table (54), and inverting the forward lookup table to generate a reverse lookup table (56). The reverse lookup table (56) can be utilized to determine correct output values (29) for driving a target display module to generate color lights within a display module color gamut.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for enabling a variable refresh rate on a display. One of the methods includes receiving, from a content presentation device, a first signal set to a first value; completing generation of first visual content; and after completing the generation of the first visual content, determining that the first signal is set to the first value and a second threshold duration of time has not expired; sending, to the content presentation device, the first visual content, wherein sending the first visual content causes the content presentation device to change the first signal from the first value to the second value; and after sending the first visual content, receiving, from the content presentation device, the first signal set to the second value.

Abstract: Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Abstract: This document describes techniques and apparatuses for performing color calibration of display modules using a reduced number of display characteristic measurements. In aspects, methods include generating a measured lookup table (50) for a source display module (32), using dynamic optimization to down-sample the measured lookup table and select a set of color patches, sending the color patches to a testing display module; measuring output values for the testing display module; generating a sparse lookup table (52) relating the color patches and the measured output values, up-sampling the sparse lookup table to a forward lookup table (54), and inverting the forward lookup table to generate a reverse lookup table (56). The reverse lookup table (56) can be utilized to determine correct output values (29) for driving a target display module to generate color lights within a display module color gamut.

Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.

Abstract: The present disclosure relates to a microfluidic device for the separation of metaphase chromosomes such that individual metaphase chromosomes may be dispensed discretely from the device. The microfluidic device comprises a flow channel including a series of expanded regions and constrictions. The present disclosure also relates to methods of separating metaphase chromosomes.

Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for enabling a variable refresh rate on a display. One of the methods includes receiving, from a content presentation device, a first signal set to a first value; completing generation of first visual content; and after completing the generation of the first visual content, determining that the first signal is set to the first value and a second threshold duration of time has not expired; sending, to the content presentation device, the first visual content, wherein sending the first visual content causes the content presentation device to change the first signal from the first value to the second value; and after sending the first visual content, receiving, from the content presentation device, the first signal set to the second value.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for enabling a variable refresh rate on a display. One of the methods includes receiving, from a content presentation device, a first signal set to a first value; completing generation of first visual content; and after completing the generation of the first visual content, determining that the first signal is set to the first value and a second threshold duration of time has not expired; sending, to the content presentation device, the first visual content, wherein sending the first visual content causes the content presentation device to change the first signal from the first value to the second value; and after sending the first visual content, receiving, from the content presentation device, the first signal set to the second value.

Abstract: An assembly for preparing a specimen is provided that may be configured to determine the presence of at least one microorganism specie in the specimen. The assembly may include a pipette configured to acquire a specimen from a sample and an imaging cartridge configured to be in fluid communication with the pipette. The imaging cartridge and the pipette may be configured to be irreversibly coupled such that the specimen is bio-contained within the imaging cartridge and the pipette when the imaging cartridge and pipette are coupled together. Associated methods of use are also provided.

Abstract: The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: A fluid device includes a base material including a flow path through which a solution flows and a first facing surface, a treatment substrate including a second facing surface which faces the first facing surface and in which a treatment unit which comes in contact with the solution and treats the solution is provided, and a sealing portion sandwiched between the first facing surface and the second facing surface, in which a treatment space surrounding the treatment unit with the sealing portion when viewed from a plate thickness direction and connected to the flow path is provided between the treatment substrate and the base material.

Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.