Patents by Inventor Daniel Solomon
Daniel Solomon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160031964Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Inventors: Mika Aoyagi-Scharber, Teresa Margaret Christianson, Melita Dvorak-Ewell, Daniel J. Wendt, Shinong Long, Jonathan LeBowitz, Daniel Solomon Gold
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Publication number: 20160031963Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.Type: ApplicationFiled: October 14, 2015Publication date: February 4, 2016Inventors: Mika Aoyagi-Scharber, Teresa Margaret Christianson, Melita Dvorak-Ewell, Daniel J. Wendt, Shinong Long, Jonathan LeBowitz, Daniel Solomon Gold
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Publication number: 20140206562Abstract: Fabrication of a microfluidic multi-temperature reaction device (MMR) and the design and fabrication of the equipment to drive various molecular biological methods on the device are provided. The device can be applicable, for example, to nucleic acid (DNA, RNA, cDNA, etc) amplification, cell lysis, reverse transcription and other enzymatic temperature sensitive and also temperature cycling reactions.Type: ApplicationFiled: January 20, 2014Publication date: July 24, 2014Applicant: QUANTUMDX GROUP LIMITEDInventors: JOHN EDWARD MCCORMACK, ELAINE HARRINGTON WARBURTON, JONATHAN JAMES O'HALLORAN, MATTHEW DANIEL SOLOMON, DAVID JAMES BRIGGS, MINDY LEE ANDRE, MATTHIAS SCHUENEMANN
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Publication number: 20140179909Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the extraction and fractionation of DNA molecules, from whole or lysed samples, in a single flow-through device.Type: ApplicationFiled: November 30, 2011Publication date: June 26, 2014Applicant: QUANTUMDX GROUP LIMITEDInventors: Jonathan James O'Halloran, Elaine Harrington Warburton, Matthew Daniel Solomon, John Edward McCormack, Matthias Schuenemann, David James Briggs, Mindy Lee Andre
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Publication number: 20140161788Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.Type: ApplicationFiled: November 27, 2013Publication date: June 12, 2014Applicant: BioMarin Pharmaceutical Inc.Inventors: Mika Aoyagi-Scharber, Teresa Margaret Christianson, Melita Dvorak-Ewell, Daniel J. Wendt, Shinong Long, Jonathan LeBowitz, Daniel Solomon Gold
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Patent number: 8609472Abstract: A process for fabricating an electronic component includes a liquid injection molding method for overmolding a semiconductor device. The liquid injection molding method includes: i) placing the semiconductor device in an open mold, ii) closing the mold to form a mold cavity, iii) heating the mold cavity, iv) injection molding a curable liquid into the mold cavity to overmold the semiconductor device, v) opening the mold and removing the product of step iv), and optionally vi) post-curing the product of step v). The semiconductor device may have an integrated circuit attached to a substrate through a die attach adhesive.Type: GrantFiled: May 26, 2011Date of Patent: December 17, 2013Assignee: Dow Corning CorporationInventors: Tammy Cheng, Mark Dobrzelewski, Daniel Solomon, Christopher Windiate
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Publication number: 20130095508Abstract: A pipette component for use in performing an experimental procedure with a fluid sample and a pipette, the pipette component including: a pipette interface configured to engage sealingly and separably with a body of the pipette; a tip interface configured to engage sealingly and separably with a replaceable tip; and an experiment region configured to receive at least part of the fluid sample by operation of the pipette, and configured to perform at least part of the experimental procedure in the experiment region using the at least part of the fluid sample.Type: ApplicationFiled: September 17, 2010Publication date: April 18, 2013Applicant: MINIFAB (AUSTRALIA) PTY LTDInventors: Andrew Paul Campitelli, Erol Craig Harvey, John Edward McCormack, Matthew Daniel Solomon, Edward Francis Wilkinson, Michael William Wilkinson, Grit Diessner
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Publication number: 20120067112Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.Type: ApplicationFiled: August 5, 2011Publication date: March 22, 2012Applicant: TearLab Research, Inc.Inventors: Benjamin Sullivan, Steve Zmina, Eric Donsky, Sasha Miu, Graeme John Bullock, Adam Ernest Donath, Fred Harry Davis, Andreas Knaack, Matthew Daniel Solomon, Erol Craig Harvey, Carl Gang Chen
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Patent number: 8020433Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.Type: GrantFiled: March 28, 2008Date of Patent: September 20, 2011Assignee: Tearlab Research, Inc.Inventors: Benjamin Sullivan, Steve Zmina, Eric Donsky, Sasha Miu, Graeme John Bullock, Adam Ernest Donath, Fred Harry Davis, Andreas Knaack, Matthew Daniel Solomon, Erol Craig Harvey, Carl Gang Chen
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Publication number: 20110221060Abstract: A process for fabricating an electronic component includes a liquid injection molding method for overmolding a semiconductor device. The liquid injection molding method includes: i) placing the semiconductor device in an open mold, ii) closing the mold to form a mold cavity, iii) heating the mold cavity, iv) injection molding a curable liquid into the mold cavity to overmold the semiconductor device, v) opening the mold and removing the product of step iv), and optionally vi) post-curing the product of step v). The semiconductor device may have an integrated circuit attached to a substrate through a die attach adhesive.Type: ApplicationFiled: May 26, 2011Publication date: September 15, 2011Inventors: Tammy Cheng, Mark Dobrzelewski, Daniel Solomon, Christopher Windiate
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Patent number: 8017449Abstract: A process for fabricating an electronic component includes a liquid injection molding method for overmolding a semiconductor device. The liquid injection molding method includes: i) placing the semiconductor device in an open mold, ii) closing the mold to form a mold cavity, iii) heating the mold cavity, iv) injection molding a curable liquid into the mold cavity to overmold the semiconductor device, v) opening the mold and removing the product of step iv), and optionally vi) post-curing the product of step v). The semiconductor device may have an integrated circuit attached to a substrate through a die attach adhesive.Type: GrantFiled: July 29, 2004Date of Patent: September 13, 2011Assignee: Dow Corning CorporationInventors: Tammy Cheng, Mark Dobrzelewski, Daniel Solomon, Christopher Windiate
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Publication number: 20080264151Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.Type: ApplicationFiled: March 28, 2008Publication date: October 30, 2008Applicant: OcuSense, Inc.Inventors: Benjamin Sullivan, Steve Zmina, Eric Donsky, Sasha Miu, Graeme John Bullock, Adam Ernest Donath, Fred Harry Davis, Andreas Knaack, Matthew Daniel Solomon, Erol Craig Harvey, Carl Gang Chen
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Publication number: 20080090332Abstract: A process for fabricating an electronic component includes a liquid injection molding method for overmolding a semiconductor device. The liquid injection molding method includes: i) placing the semiconductor device in an open mold, ii) closing the mold to form a mold cavity, iii) heating the mold cavity, iv) injection molding a curable liquid into the mold cavity to overmold the semiconductor device, v) opening the mold and removing the product of step iv), and optionally vi) post-curing the product of step v). The semiconductor device may have an integrated circuit attached to a substrate through a die attach adhesive.Type: ApplicationFiled: July 29, 2004Publication date: April 17, 2008Inventors: Tammy Cheng, Mark Dobrzelewski, Daniel Solomon, Christopher Windiate
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Publication number: 20070167435Abstract: Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: M is CH or N; U and W are each CH, or one of U and W is CH and the other is N; X is a bond, alkylene, —C(O)—, —C(N—OR5)—, —C(N—OR5)—CH(R6)—, —CH(R6)—C(N—OR5)—, —O—, —OCH2—, —CH2O— or —S(O)0-2—; Y is —O—, —(CH2)2—, —C(?O)—, —C(?NOR7)— or —SO0-2—; Z is a bond, optionally substituted alkylene or alkylene interrupted by a heteroatom or heterocyclic group; R1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, or benzimidazolyl or a derivative thereof; R2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods for treating an allergy-induced airway response, congestion, diabetes, obesity, an obesity-related disorder, metabolic syndrome and a cognition deficit disorder using said compounds, alone or in combinatType: ApplicationFiled: December 19, 2006Publication date: July 19, 2007Inventors: Mwangi Mutahi, Robert Aslanian, Michael Berlin, Christopher Boyce, Manuel de Lera Ruiz, Kevin McCormick, Daniel Solomon, Henry Vaccaro, Junying Zheng, Purakkattle Biju, Younong Yu, Wei Zhou, Xiaohong Zhu
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Publication number: 20070142394Abstract: Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein M1 is M2 is N; X is a bond, optionally substituted alkylene, alkenylene, —O—, —CH2N(R12)—, —N(R12)CH2—, —N(R12)—, —NHC(O)—, —OCH2—, —CH2O—, or —S(O)0-2—; and Y is —(CH2)1-2—, —C(?O)—, —C(?NOR13)— or —SO0-2—; or M1 is N; M2 is N or CH; X is a bond, alkylene, alkenylene, —C(O)—, —NHC(O)—, —OC(O)— or —S(O)1-2—; Y is —(CH2)1-2—, —C(?O)— or —SO0-2—; and when M2 is CH, Y is also Y is —O— or —C(?NOR13)—; Z is a bond or optionally substituted alkylene or alkenylene; U and W are CH, or one is CH and one is N; R1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl; R2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods of treating obesity, metabolic syndrome and a cognition deficit disorder, alone or in combinationType: ApplicationFiled: December 19, 2006Publication date: June 21, 2007Inventors: Daniel Solomon, Robert Aslanian, Michael Berlin, Manuel de Lera Ruiz, Kevin McCormick, Mwangi Mutahi, Wing Tom
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Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists
Publication number: 20070015807Abstract: Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: M1 and M3 are CH or N; M2 is CH, CF or N; Y is —C(?O)—, —C(?S)—, —(CH2)q—, —C(?NOR7)— or —SO1-2—; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, or alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, all optionally substituted, or a group of the formula: where ring A is a heteroaryl ring; R2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; R3 is H, —C(O)NH2, or alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, all optionally substituted; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome, alcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma and cognition deficit disorders using said compounds, alone or in combination with other ageType: ApplicationFiled: June 19, 2006Publication date: January 18, 2007Inventors: Robert Aslanian, Michael Berlin, Christopher Boyce, Jianhua Chao, Manuel de Lera Ruiz, Pietro Mangiaracina, Kevin McCormick, Mwangi Mutahi, Stuart Rosenblum, Neng-Yang Shih, Daniel Solomon, Wing Tom, Henry Vaccaro, Junying Zheng, Xiaohong Zhu -
Publication number: 20050113383Abstract: Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.Type: ApplicationFiled: October 27, 2004Publication date: May 26, 2005Inventors: Stuart Rosenblum, Qingbei Zeng, Mwangi Mutahi, Robert Aslanian, Pauline Ting, Neng-Yang Shih, Daniel Solomon, Jianhua Cao, Henry Vaccaro, Kevin McCormick, John Baldwin, Ge Li
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Publication number: 20030053896Abstract: A clamshell packaging container for storing and handling multiple compact discs. The container has a base and a cover, the base being configured to hold a plurality of concentrically stacked compact discs while providing free access for a handling spindle to be inserted through aligned the central apertures of the discs when the container is open.Type: ApplicationFiled: September 18, 2001Publication date: March 20, 2003Inventors: Daniel Solomon Kern, Benjamin David Kern
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Patent number: 5890774Abstract: The present invention provides a new customizable folio system that is useful for presenting selectable optical characteristics to one face of a folio cover. The selectable optical characteristics are presented at one face of the folio cover as the result of selective replacement of insert sheet(s) that are placed into a pocket formed between the outer folio cover sheet and an inner backing sheet. Either the outer front face of the folio cover, or the inner backing sheet has at least one cutout section(s) therein, of any desired shape or design, through which selective part(s) of the insert sheet(s) can be viewed. The insert sheet(s) have optical characteristic(s) that are different from those of either the outer front face of the folio cover or the inner backing sheet, at least in those areas of the insert sheet that can be seen through the cutout section(s).Type: GrantFiled: October 18, 1996Date of Patent: April 6, 1999Assignee: Post-Fax Inc.Inventors: Douglas G. Schwartz, Larry Leibe Mogelonsky, Daniel Solomon Schwartz
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Patent number: 5449680Abstract: Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.Type: GrantFiled: October 2, 1992Date of Patent: September 12, 1995Assignee: Schering CorporationInventors: Daniel Solomon, James J. Kaminski, Steven K. White, Laura S. Lehman de Gaeta, Ashit K. Ganguly