Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A cutting and harvesting assembly for an agricultural machine includes a structural frame. A feed roller is operably coupled with the structural frame. A deflector assembly is operably coupled with the structural frame. The deflector assembly includes a deflector plate at least partially laterally outward of the feed roller. The deflector plate is rotatable between a first position and a second position relative to the structural frame.

Abstract: User identities can managed at an organization level, instead of across multiple individual resource accounts. In a resource provider environment, access to various resources and services may require users to have identities with specific resource accounts. Users can instead be associated with organization accounts, or virtual accounts that are not associated with specific resources or services. The organization accounts are attached at the appropriate location(s) in an organizational hierarchy. A user having an organization account can project the identity in any sub-account in the organization hierarchy. This can include any lower-level resource account, or can child accounts under a relevant branch of the hierarchy. A user can validate against the organization account, and receive access to the relevant service or resources using the identity projected in the corresponding resource account.

Abstract: Preventing freezing in a heat exchanger can include passing first and second cooling fluids through the heat exchanger, monitoring a temperature and/or pressure of the second cooling fluid entering the heat exchanger, heating the second cooling fluid entering the heat exchanger by opening a valve when the monitored temperature and/or monitored pressure is below a trigger temperature and/or trigger pressure, and closing the valve when a condition is met. The first cooling fluid can have a first freezing temperature and the second cooling fluid can have a second, lower freezing temperature. Opening the valve can cause the second cooling fluid, in gaseous phase, to mix with the second cooling fluid, in liquid phase, upstream of the heat exchanger.

Abstract: A wing structure having a unitary body formed by a plurality of tubular sections that are arranged side-by-side and configured such that adjacent internal walls of the tubular sections create internal spar structures that substantially reduce or eliminate the need for non-integral spars, or for fasteners to attach conventional spars and ribs into the wing skins. The unitized structure formed by the plurality of tubular sections can be further overwrapped with a composite material to provide additional strength to the wing structure.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: The updating of a definition layer or schema for a large distributed database can be accomplished using a plurality of data store tiers. A distributed database can be made up of many individual data stores, and these data stores can be allocated across a set of tiers based on business logic or other allocation criteria. The update can be applied sequentially to the individual tiers, such that only data stores for a single tier are being updated at any given time. This can help to minimize downtime for the database as a whole, and can help to minimize problems that may result from an unsuccessful update. Such an approach can also allow for simplified error detection and rollback, as well as providing control over a rate at which the update is applied to the various data stores of the distributed database.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining a classification that applies to the electronic message. The classification is determined based on an express indication from a user. The method further comprises providing a machine learning trainer with the electronic message and an identification of the classification that applies to the electronic message. The machine learning trainer is adapted to determine a machine learning policy that associates attributes of the electronic message with the classification.

Abstract: Described implementations obtain credential information including an encrypted digital identity (ID). The encrypted digital ID may include a public component of a credential and identity data. Furthermore, the credential information may include cryptographically obfuscated data based on the identity data and a private component of the credential. A proof is obtained that includes proof data. The proof data may confirm that the credential information was correctly generated. Verification of the proof data, and confirmation that the cryptographically obfuscated data is not associated in a collection of cryptographically obfuscated data, cause a computer-implemented service to issue a pseudonym. The pseudonym is usable to generate a relationship associated with a computer-implemented service.

Abstract: A cutting and harvesting assembly for an agricultural machine includes a structural frame. A central portion divider set is operably coupled with the structural frame and includes one or more central portion feed rollers. A first line divider set is laterally offset from the central portion divider set. The first line divider set includes a first pivoting frame, a first connection element operably coupled to the first pivoting frame and the structural frame, one or more first set feed rollers operably coupled with the first pivoting frame. A second line divider set is positioned on an opposing side of the central portion divider set from the first line divider set. The second line divider set includes a second pivoting frame, a second connection element operably coupled to the second pivoting frame and the structural frame, and one or more second set feed rollers operably coupled with the second pivoting frame.

Abstract: According to some embodiments, a method performed by a classification scanner comprises receiving an electronic message and determining whether the electronic message includes an express indication from the user indicating that a classification applies to the electronic message. In response to determining that the electronic message does not include the express indication that the classification applies to the electronic message, the message further comprises sending the electronic message to a machine learning scanner. The machine learning scanner is adapted to use a machine learning policy to determine whether the classification applies to the electronic message.

Abstract: A method and apparatus for testing and simulating an access control policy are disclosed. Evaluating an access control policy may be performed by utilizing a deny statement that causes the access request to be rejected despite actions indicated in the access request being authorized. Further, an independent simulation environment may be utilized for testing access control policy evaluation.

Abstract: Visual content of media programs is recognized using text-based scripts of the media programs. A script of a media program includes sets of words to be spoken by actors during the media program, and also descriptions of points of interest of the media program. A file of subtitles or captions of a media program includes sets of words actually spoken by actors during the media program along with marks or stamps of times when such words were spoken. The sets of words of a script and in subtitles or captions are processed to determine where such words align. The sets of words of the script are then marked or stamped with times from the subtitles. The descriptions may then be processed to predict the visual content from such descriptions, and times at which the visual content appears within the media program are determined from the sets of words.

Abstract: Methods and systems for calibrating a transmission electron microscope are disclosed. A fiducial mark on the sample holder is used to identify known reference points so that a current collection area and a through-hole on the sample holder can be located. A plurality of beam current and beam area measurements are taken, and calibration tables are extrapolated from the measurements for a full range of microscope parameters. The calibration tables are then used to determine electron dose of a sample during an experiment at a given configuration.

Abstract: A fluid metering system for gas independent pressure and flow control through an electron microscope sample holder includes: a pressure control system that supplies gas; an inlet line providing gas from the pressure control system to the sample holder; an outlet line receiving gas from the sample holder; and a variable leak valve that controls gas flow in the outlet line. The gas flows from an upstream tank of the pressure control system through the sample holder and variable leak valve to a downstream tank of the pressure control system due to the pressure difference of the two tanks as the variable leak valve meters flow in the outlet line. Flow rates are established by monitoring pressure changes at source and collection tanks of known volumes with gas independent pressure gauges. A method of directing the gas flow to a residual gas analyzer (RGA) is also presented.

Abstract: Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.

Abstract: A request to modify a set of permissions (e.g., delete the permissions, replace the set of permissions with a different set of permissions) is received at a computing device. A set of services are prevented from using the set of permissions to access resources. The set of permissions are changed while the set of services are prevented from using the set of permissions to access resources.

Abstract: Systems and methods for displaying a graphical user interface that represents an arrangement of components in a room. Based on inputs from the user and/or default settings regarding one or more of the components, a visual representation of the room is generated for outputting to view on a display screen of s user device. The graphical user interface facilitates a user in designing and selecting components for the room.

Abstract: A method of operating a household appliance, where the household appliance includes a camera assembly operable to obtain an image, is provided. The method includes downloading a protected user detection software from a remote computing device to the household appliance. The method also includes unlocking a user interface of the household appliance. The method further includes detecting, with the camera assembly, a user at the household appliance after unlocking the user interface and using the protected user detection software to determine that the detected user is a protected user. In response to detecting the protected user, the user interface is locked.

Abstract: A blender system includes a container having a rotatable blade assembly therein, a lid covering an open end of the container, and a base with a motorized unit. When the container is coupled with the base, the motorized unit is adapted to drive rotation of the rotatable blade assembly. The lid includes a hinged actuator lever adapted to actuate the motorized unit. A detent extends from the hinged actuator lever and passes through a series of apertures and presses against a slidable actuator shaft disposed in the container and maintained in its position by a spring force, thereby depressing a switch for the motorized unit. A rotatable blade system includes cutting blade(s) and crushing blade(s). The crushing blade extends longitudinally outwardly from a hub. When the hub rotates in a first direction or second direction opposite the first direction, a face of the crushing blade is leading or trailing, respectively.