Patents by Inventor Daniel T. Chiu

Daniel T. Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biochip for high-throughput screening of circulating tumor cells
    Patent number: 10035104
    Abstract: Embodiments in accordance with the present invention relate to the use of effusive filtration to segregate tumor cells from a sample of bodily fluid. In one embodiment, fluid containing a cell is flowed down a channel having a filtration medium present along at least one side wall. The tumor cell is captured when the fluid passes through the filtration medium. Accumulated pressure on the captured tumor cell is reduced by allowing the fluid that has passed through the filtration medium to re-enter the channel. In a particular embodiment, the filtration medium may comprise side wall apertures having a width smaller than that of the cell, with downstream apertures allowing re-entry of the fluid into the channel.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: July 31, 2018
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Jason S. Kuo, J. Patrick Shelby, David S. Lim
  • Methods and systems for performing digital measurements
    Patent number: 10000797
    Abstract: Methods, devices and systems for performing digital measurements are provided.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: June 19, 2018
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Bryant S. Fujimoto, Alexander R. Gansen, Gloria S. Yen, Robert M. Lorenz
  • Methods and devices for generating double emulsions
    Patent number: 9997344
    Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 12, 2018
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Dingsheng Liu
  • OPTICAL PAINTING AND FLUORESCENCE-ACTIVATED SORTING OF ADHERENT CELLS
    Publication number: 20180080863
    Abstract: The present disclosure provides a method of optically marking and sorting adherent cells. In some aspects, the method comprises: providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells comprising an optical marker; selectively applying light energy to a subset of the plurality of adherent cells; detaching the plurality of adherent cells from the substrate; and sorting the plurality of adherent cells.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 22, 2018
    Inventors: Daniel T. Chiu, Chun-Ting Kuo, Jiangbo Yu
  • Chromophoric polymer dots
    Patent number: 9810693
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: November 7, 2017
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Highly fluorescent polymer nanoparticle
    Patent number: 9797840
    Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: October 24, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Fangmao Ye
  • METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS
    Publication number: 20170250063
    Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
    Type: Application
    Filed: March 9, 2017
    Publication date: August 31, 2017
    Inventors: Daniel T. CHIU, Dingsheng LIU
  • Methods and apparatus for the isolation and enrichment of circulating tumor cells
    Patent number: 9733165
    Abstract: Embodiments in accordance with the present invention relate to methods and apparatuses for concentrating and isolating Circulating Tumor Cells (CTCs) from body fluids. One embodiment of the present invention includes a micro-fabricated or nano-fabricated device having channels configured for separating and excluding. Embodiments in accordance with the present invention utilize features that reduce the hydrodynamic pressure experienced by the cells during the separation, isolation and concentration processes, and therefore reduce the likelihood of cell lysis or other damage to the cells.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 15, 2017
    Assignee: University of Washington
    Inventors: Daniel T. Chiu, Jason S. Kuo
  • METHODS AND APPARATUS FOR PERFORMING DIGITAL ASSAYS USING POLYDISPERSE DROPLETS
    Publication number: 20170175174
    Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.
    Type: Application
    Filed: April 8, 2015
    Publication date: June 22, 2017
    Inventors: Daniel T. CHIU, Jason E. KREUTZ, Gloria S. YEN, Bryant S. FUJIMOTO
  • METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS
    Publication number: 20170145490
    Abstract: Methods, devices and systems for performing digital measurements are provided.
    Type: Application
    Filed: August 5, 2016
    Publication date: May 25, 2017
    Inventors: Daniel T. Chiu, Bryant S. Fujimoto, Alexander R. Gansen, Gloria S. Yen, Robert M. Lorenz
  • ENCODED CHROMOPHORIC POLYMER PARTICLES AND METHODS OF USE THEREOF
    Publication number: 20170003293
    Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
    Type: Application
    Filed: November 25, 2014
    Publication date: January 5, 2017
    Inventors: Daniel T. Chiu, Changfeng Wu, Jiangbo Yu
  • SELF-DIGITIZATION OF SAMPLE VOLUMES
    Publication number: 20160354777
    Abstract: Devices, systems and apparatuses for the discretization and manipulation of sample volumes are provided. Related methods are also provided.
    Type: Application
    Filed: June 25, 2014
    Publication date: December 8, 2016
    Inventors: Daniel T. CHIU, Thomas SCHNEIDER, Jason E. KREUTZ
  • CHROMOPHORIC POLYMER DOTS
    Publication number: 20160341737
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Application
    Filed: May 27, 2016
    Publication date: November 24, 2016
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • Methods and systems for performing digital measurements
    Patent number: 9428793
    Abstract: Methods, devices and systems for performing digital measurements are provided.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: August 30, 2016
    Assignee: University of Washington Through Its Center For Commercialization
    Inventors: Daniel T. Chiu, Bryant S. Fujimoto, Alexander R. Gansen, Gloria S. Yen, Robert M. Lorenz
  • Chromophoric polymer dots
    Patent number: 9382473
    Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: July 5, 2016
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Daniel T. Chiu, Changfeng Wu, Xuanjun Zhang, Jiangbo Yu, Fangmao Ye
  • HYBRID SEMICONDUCTING POLYMER NANOPARTICLES AS POLARIZATION-SENSITIVE FLUORESCENT PROBES
    Publication number: 20160161475
    Abstract: Compositions of, methods of making, and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and at least one nonsemiconducting polymer. Compositions of, methods of making and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and non-semiconducting polymers wherein the non-semiconducting polymer comprises more than one non-semiconducting polymer such that at least one non-semiconducting polymer is functionalized for bioconjugation. The hybrid nanoparticles are polarization-sensitive and have low mass ratios with large fluorescence.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 9, 2016
    Inventors: Daniel T. CHIU, Maxwell ZEIGLER
  • METHODS, COMPOSITIONS AND SYSTEMS FOR MICROFLUIDIC ASSAYS
    Publication number: 20160146823
    Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
    Type: Application
    Filed: July 1, 2014
    Publication date: May 26, 2016
    Inventors: Daniel T. CHIU, Mengxia ZHAO, Wyatt NELSON, Perry G. SCHIRO
  • METHOD AND APPARATUS FOR THE DISCRETIZATION AND MANIPULATION OF SAMPLE VOLUMES
    Publication number: 20160096172
    Abstract: Embodiments of the present invention relate to methods and apparatuses for the discretization and manipulation of sample volumes that is simple, robust, and versatile. It is a fluidic device that partitions a sample by exploiting the interplay between fluidic forces, interfacial tension, channel geometry, and the final stability of the formed droplet and/or discretized volume. These compartmentalized volumes allow for isolation of samples and partitioning into a localized array that can subsequently be manipulated and analyzed.
    Type: Application
    Filed: September 29, 2015
    Publication date: April 7, 2016
    Inventors: Daniel T. Chiu, Dawn E. Cohen, Gavin D.M. Jeffries
  • METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS
    Publication number: 20160086785
    Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
    Type: Application
    Filed: May 30, 2014
    Publication date: March 24, 2016
    Inventors: Daniel T. CHIU, Bejan HAKIMI, Dingsheng LIU, Frantisek TURECEK, Michael VOLNY, Joelle ROLFS
  • POLYMER DOT COMPOSITIONS AND RELATED METHODS
    Publication number: 20160018395
    Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 21, 2016
    Inventors: Daniel T. CHIU, Wei SUN, Jiangbo YU, Changfeng WU, Fangmao YE