Abstract: A system includes a position indicator and a processing device which enable a user to intuitively and dynamically specify dimensions and shapes of objects. The position indicator transmits a signal indicative of a pressure applied to a part of the position indicator. The processing device receives the signal indicative of the pressure applied to the part of the position indicator and signals indicative of respective positions of the position indicator. The processing device generates visualization data based on the signal indicative of the pressure applied to the part of the position indicator and the signals indicative of the respective positions of the position indicator. The visualization data defines an object that extends from a predetermined position in a direction that is based on the signal indicative of the pressure applied to the part of the position indicator.

Abstract: A method for displaying a three-dimensional object based on user operation of a position indicator. The method includes defining a two-dimensional shape based on movement of a tip of the position indicator on an input surface; determining a direction in which the two-dimensional shape extends, based on at least one of a pressure applied to the input surface by the position indicator or an acceleration of the position indicator; generating a representation of a three-dimensional object extruded from the two-dimensional shape in the direction in which the two-dimensional shape is determined to extend; and displaying the three-dimensional object on a display.

Abstract: An enclosure system that can include a first component, a second component, and a self-threading screw. The first component can include a first cutout, the first cutout including a first internal perimeter that defines a first cutout interface. The second component can include a second cutout, the second cutout including a second internal perimeter that defines a second cutout interface. The first cutout interface can be non-circular and include a first plurality of interface sides. The self-threading screw can include a screw thread. The self-threading screw can be threadedly-engaged with the first cutout interface and the second cutout interface to secure the first component on or within an enclosure, with a first plurality of discrete engagement portions of the screw thread threadedly engaging the first plurality of interface sides of the first cutout interface to secure the screw to the first component.

Abstract: A method and system for three-dimensional (3D) surface sketching are provided. A 3D scanner scans an outer surface of a physical object and outputs data representative of the outer surface. A processor generates, based on the received data, a 3D model of the object and outputs a 3D rendering of the object. A display displays the 3D rendering of the object. An input device physically traces over a portion of the outer surface of the object and a tracking device tracks a positioning of the input device as the input device physically traces over the portion of the outer surface of the object. The processor receives data representative of at least one spatial position of the input device, augments the 3D rendering of the object based at least in part on the data and outputs the augmented 3D rendering to the display.

Abstract: The present invention relates generally to methods for preventing and/or treating myeloproliferative disorders. More specifically, the myeloproliferative disorders are those associated with the presence of a frameshift mutation in the calreticulin (CALR) gene of a cell involved in the myeloproliferative disorders. The present invention also relates to immunological agents, such as antibodies, to calreticulin, methods for preventing and/or treating myeloproliferative diseases using the immunological agents, and chimeric antigen receptors having extracellular domains based on antibodies to calreticulin.

Abstract: Provided herein are methods for treating a subject having chronic myelomonocytic leukemia (CMML), the method comprising: (a) identifying a RAS pathway mutation in tumor cells of the subject, wherein the RAS pathway mutation is a NRAS, KRAS, PTPN-11 and/or CBL mutation; (b) identifying a dominant CBL mutation of CBL variant allele frequency of from <5% to >10%; and (c) administering to the subject identified in step (a) a therapeutically effective amount of an anti-hGM-CSF antibody.

Abstract: Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.

Abstract: Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.

Abstract: An improved drive shaft for controlling an end effector of surgical instrument having advantages over the prior art, specifically, the drive shaft includes two separate elongate elements, each including a flange at its proximal end for restricting the lateral movement of the drive shaft when installed within an outer shaft of the instrument. The dimensions of the flanges are such that they fit within the outer shaft with minimal clearance. This allows the drive shaft to be moved longitudinally within the outer shaft to actuate an end effector whilst minimizing any lateral movement. This consequently prevents the end effector from tilting as it is actuated. The drive members are arranged so that the flanges extend in opposite directions perpendicular to the length of the drive shaft. This helps to improve ease of assembly and provides space within the outer shaft for features such as connection wires and the like.

Abstract: An improved drive shaft for controlling an end effector of surgical instrument having advantages over the prior art, specifically, the drive shaft includes two separate elongate elements, each including a flange at its proximal end for restricting the lateral movement of the drive shaft when installed within an outer shaft of the instrument. The dimensions of the flanges are such that they fit within the outer shaft with minimal clearance. This allows the drive shaft to be moved longitudinally within the outer shaft to actuate an end effector whilst minimizing any lateral movement. This consequently prevents the end effector from tilting as it is actuated. The drive members are arranged so that the flanges extend in opposite directions perpendicular to the length of the drive shaft. This helps to improve ease of assembly and provides space within the outer shaft for features such as connection wires and the like.

Abstract: Provided herein are methods for treating a subject having chronic myelomonocytic leukemia (CMML), the method comprising: (a) identifying a RAS pathway mutation in tumor cells of the subject, wherein the RAS pathway mutation is a NRAS, KRAS, and/or CBL mutation; and (b) administering to the subject identified in step (a) a therapeutically effective amount of an anti-hGM-CSF antibody. The subject may have a RAS pathway mutation or a RAS pathway mutation and at least one TET2 mutation identified in the tumor cells. The methods further comprise administering a therapeutically effective amount of a hypomethylating agent.

Abstract: A system includes a position indicator and a processing device which enable a user to intuitively and dynamically specify dimensions and shapes of objects. The position indicator transmits a signal indicative of a pressure applied to a part of the position indicator. The processing device receives the signal indicative of the pressure applied to the part of the position indicator and signals indicative of respective positions of the position indicator. The processing device generates visualization data based on the signal indicative of the pressure applied to the part of the position indicator and the signals indicative of the respective positions of the position indicator. The visualization data defines an object that extends from a predetermined position in a direction that is based on the signal indicative of the pressure applied to the part of the position indicator.

Abstract: A system includes a position indicator and a processing device which enable a user to intuitively and dynamically specify dimensions and shapes of objects. The position indicator transmits a signal indicative of a pressure applied to a part of the position indicator. The processing device receives the signal indicative of the pressure applied to the part of the position indicator and signals indicative of respective positions of the position indicator. The processing device generates visualization data based on the signal indicative of the pressure applied to the part of the position indicator and the signals indicative of the respective positions of the position indicator. The visualization data defines an object that extends from a predetermined position in a direction that is based on the signal indicative of the pressure applied to the part of the position indicator.

Abstract: Process mining systems and methods are provided for automatically identifying unknown decision making factors.

Abstract: A system, device and method to facilitate tying a knot are provided. In the context of a device, the device includes a fixture defining an internal passage therethrough. The fixture defines a circumferential groove opening through an interior surface of the fixture and into the internal passage. The groove includes first and second groove portions that cross one another. Opposite ends of the groove are coincident and open through an exterior surface of the fixture. With relation to a system, the system includes a fixture and a lead member supply mechanism configured to alternately feed a lead member through the groove and to withdraw the lead member from the groove once the tie member is connected thereto.

Abstract: A vehicle display assembly includes a display configured to graphically depict information. A printed circuit board (PCB) is in communication with the display. A carrier is clamped between the display and PCB to form an instrument cluster assembly. The carrier includes cooling fins.

Abstract: Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.

Abstract: A computer system for performing automated market research using an electronic survey is provided herein. The computer system includes a communications subsystem for receiving survey content data. The communications subsystem also receives survey response data from at least one respondent device. The computer system includes a memory for storing the survey content data and the survey response data. The computer system includes a processor configured to execute a survey programming application. The survey programming application includes a survey design application for creating a survey program from the survey content data. The survey program provisions the electronic survey to respondents via the at least one respondent device and collects the survey response data from the respondents. The survey programming application also includes at least one survey program quality assurance tool.

Abstract: Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.