Abstract: The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

Abstract: Disclosed herein is a golf bag cover for use in covering a golf bag having golf clubs placed therein. The golf bag cover is configured to couple to the bottom portion of a golf bag in a closed position and can selectively cover the golf bag and golf clubs in an open position. In the closed position, the golf bag cover can collapse into an integrated pouch and remain attached to the base of the golf bag.

Abstract: Implementations of the disclosure provide for size adjustable volumes for containers. A method of the disclosure includes determining, by a processing device of a Platform-as-a-Service (PaaS) system, a size limitation of a container, where the size limitation is associated with disk space usage of a storage volume group. The amount of disk space used by applications of the container is monitored in view of the size limitation of the container. Responsive to determining that the amount of the disk space used by the applications of the container satisfies a threshold, a storage volume of the storage volume group is allocated to the container in view of the size limitation of the container.

Abstract: Methods for treating age-related eye diseases or conditions are provided. Methods for treating an age-related eye disease or condition in a subject by administering one or more demethylation compounds or agents are provided.

Abstract: A system comprises a negative-pressure source including a pump and an electric motor for maintaining negative-pressure at the wound and a pressure sensor for sensing a wound site pressure (WP). The system further comprises a system controller coupled to the first pressure sensor and the electric motor. The system controller maintains the wound site pressure (WP) within a hysteresis band by the application of power to the electric motor from a battery power source, based upon, at least in part a flow rate (FR) of fluid between the pump and the wound site as determined by the system controller. The hysteresis band including a maximum wound site pressure (WPMax) and a minimum wound site pressure (WPMin).

Abstract: Database schema management systems and methods. An intake engine can receive a platform-specific schema definition language and an intake template for converting the input schema to a platform-neutral schema. The intake template can define one or more translation operations required to convert from the first platform-specific schema definition language to a platform-neutral schema definition language. In embodiments, the intake engine can validate the input schema based on one or more design criteria. A repository can store platform-neutral schemas and deployment information. An output template can define one or more translation operations to convert from the platform-neutral schema definition language to a platform-specific schema definition language. A deployment engine can deploy a selected schema to a target database upon request.

Abstract: One device disclosed herein includes a gate above a semiconductor substrate, the gate comprising a gate structure and a gate cap, and conductive source/drain metallization structures adjacent the gate, each of the conductive source/drain metallization structures having a front face and a recess defined in each of the conductive source/drain metallization structures. In this example, the device further includes a spacer structure comprising recess filling portions that substantially fill the recesses and a portion that extends across a portion of the upper surface of the gate cap, wherein a portion of the gate cap is exposed within the spacer structure, an insulating material within the spacer structure and on the exposed portion of the gate cap, a gate contact opening that exposes a portion of an upper surface of the gate structure, and a conductive gate contact structure in the conductive gate contact opening.

Abstract: A radio frequency (RF) transmitter includes a set of input ports to receive baseband samples of a signal to be transmitted on a set of disjoint frequency bands, a set of filter banks, there is one filter bank for each input port, each filter bank includes a plurality of digital polyphase interpolation filters to sample a shifted phase of the corresponding sequence of baseband samples and to interpolate the sampled phases to produce a plurality of sequences of interpolated baseband phased samples with the shifted phase, and a set of oscillators banks, each oscillator bank includes a plurality of polyphase Digital Direct Synthesizer (DDS) corresponding to the plurality of digital polyphase interpolation filters to generate a plurality of sequences of samples of digital waveform.

Abstract: An actuator is introduced that utilizes the forces that result from placing a current carrying coil in a magnetic field to rotate a connected object about at least one axis. In some embodiments, the introduced coil actuator includes a coil of conductor coupled to an arm or other type of structural element that extends radially from an axis of rotation. The introduced coil actuator can be utilized to provide motion control in a variety of different applications such as gimbal mechanisms. In some embodiments, the introduced coil actuator can be implemented in a gimbal mechanism for adjusting an orientation of a device such as a camera relative to a connected platform such as the body of an aerial vehicle.

Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g., to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization.

Abstract: The present disclosure provides a pulley, comprising a cylindrical wall having an outer surface with a plurality of circumferential grooves configured to receive a corresponding plurality of ribs on an inner surface of an elastic belt, a web connected to an inner surface of the cylindrical wall, a central hub connected to the web, the central hub comprises a central opening sized to be press-fit onto a drive shaft, and a drive feature configured to mate with a drive tool, thereby facilitating rotation of the pulley using the drive tool.

Abstract: A device for electrical energy management of a vehicle system of a motor vehicle includes a power supply for supplying energy to the vehicle system of the motor vehicle. The power supply has a normal operation mode and a stand-by operation mode. A distributing device has voltage levels on the output side for supplying electrical energy to vehicle system components of the vehicle system. A state-monitoring device monitors the electrical energy supply of the power supply and controls tire distributing device. A computer device has an operating system device and a volatile computer data memory that is designed to be kept energized even in the stand-by operation mode of the device for energy management, in such a way that the volatile computer data memory does not lose the data stored therein. A method and a motor vehicle corresponding to the device are also provided.

Abstract: An apparatus is described. The apparatus includes an image processing unit. The image processing unit includes a plurality of stencil processor circuits each comprising an array of execution unit lanes coupled to a two-dimensional shift register array structure to simultaneously process multiple overlapping stencils through execution of program code. The image processing unit includes a plurality of sheet generators respectively coupled between the plurality of stencil processors and the network. The sheet generators are to parse input line groups of image data into input sheets of image data for processing by the stencil processors, and, to form output line groups of image data from output sheets of image data received from the stencil processors. The image processing unit includes a plurality of line buffer units coupled to the network to pass line groups in a direction from producing stencil processors to consuming stencil processors to implement an overall program flow.

Abstract: A gearbox includes a sun gear, a plurality of planet gears, an annulus gear and a planet carrier. The planet carrier includes a first ring, second ring spaced axially from the first ring, a plurality of circumferentially spaced axles and a plurality of circumferentially spaced support structures extending axially between and secured to the first ring and second ring. Each planet gear is rotatably mounted on a respective one of the axles. The first ring has a plurality of circumferentially spaced recesses and the second ring has a plurality of circumferentially spaced recesses. Each recess in the second ring is aligned with a corresponding one of the recesses in the first ring. A first end of each support structure locates in a recess in the first ring. A second end of each support structure locates in a recess in the second ring. Each support structure comprises a fused powdered material.

Abstract: The present disclosure relates to methods for forming replacement metal gate (RMG) structures and related structures. A method may include: forming a portion of sacrificial material around each fin of a set of adjacent fins; forming a first dielectric region between the portions of sacrificial material; forming a second dielectric region on the first dielectric region; forming an upper source/drain region from an upper portion of each fin; removing only the second dielectric region and the sacrificial material; and forming a work function metal (WFM) in place of the second dielectric region and the sacrificial material. The semiconductor structure may include gate structures surrounding adjacent fins; a first dielectric region between the gate structures; a second dielectric region above the first dielectric region and between the gate structures; and a liner between the first dielectric region and the gate structures such that the second dielectric region directly contacts the gate structures.

Abstract: Composite components and methods for adding a composite material to a composite component are provided. For example, a method comprises positioning a composite material segment against the composite component to form a component layup; applying an insulating material around at least a portion of the component layup to form an insulated layup; and densifying the insulated layup, where the composite component was previously densified before positioning the composite material segment against the composite component. In some embodiments, the composite material is ceramic matrix composite (CMC) and the composite material segment is a plurality of CMC plies. The composite component may be a CMC gas turbine engine component that comprises an original CMC component and a new CMC material segment joined to the original CMC component through the transfer of silicon between the original CMC component and the new CMC material segment during melt infiltration.

Abstract: A mobile device responds in real time to media content presented on a media device, such as a television. The mobile device captures temporal fragments of audio-video content on its microphone, camera, or both and generates corresponding audio-video query fingerprints. The query fingerprints are transmitted to a search server located remotely or used with a search function on the mobile device for content search and identification. Audio features are extracted and audio signal global onset detection is used for input audio frame alignment. Additional audio feature signatures are generated from local audio frame onsets, audio frame frequency domain entropy, and maximum change in the spectral coefficients. Video frames are analyzed to find a television screen in the frames, and a detected active television quadrilateral is used to generate video fingerprints to be combined with audio fingerprints for more reliable content identification.

Abstract: In certain aspects, the disclosed implementations include methods and systems for providing transaction affinity merchant recommendation information performed by transaction affinity platform computing components that execute software stored in a memory. In certain aspects, the disclosed implementations may determine transaction affinity relationship data for transactions associated with a set of account records. Each account record in the set of account records may be associated with a set of users. The disclosed implementations may also determine transaction affinity relationship profiles based on transaction affinity profile parameters that are associated with the transaction affinity relationship data and first transaction data. Further, the disclosed implementations may determine one or more transaction affinity patterns based on the transaction affinity relationship data and the transaction affinity relationship profiles.

Abstract: An aerial deployed radio antenna system includes a primary aerial vehicle and a plurality of secondary aerial vehicles coupled to the primary aerial vehicle with a primary tether, wherein the plurality of secondary aerial vehicles are coupled to each other with a plurality of secondary tethers. The system also includes a radar-reflective sheet suspended between and supported by a plurality of cables coupled to the plurality of secondary aerial vehicles, wherein the radar-reflective sheet forms a parabolic reflector shape when deployed and towed by the primary aerial vehicle. A radar transmitter/receiver is positioned relative to the radar-reflective sheet to transmit radar signals toward the radar-reflective sheet and receive radar signals focused by the radar-reflective sheet, and a plurality of solar cells is positioned on the radar-reflective sheet.