Abstract: This disclosure relates to a nucleic acid comprising a double stranded RNA molecule comprising sense and antisense strands and further comprising a single stranded DNA molecule covalently linked to the 3? end of either the sense or antisense RNA part of the molecule.

Abstract: Service cells are provided for wireless communication between user equipment and a core network. An aerial vehicle provides service cells for wireless communication between user equipment (UE) and a core network. A plurality of listening cells are provided across a service area associated with an aerial vehicle, and user equipment located in the service area are associated with at least one listening cell. It is determined which listening cells are qualifying listening cells that are listening cells that satisfy at least one predetermined condition, and subsequently at least one service cell in the service area is provided for each qualifying listening cell.

Abstract: A fluid heating system including a burner unit is operated based on feedback control loops. The fluid heating system comprises a burner unit configured to heat a fluid, a sensor configured to sense a characteristic of the appliance, and a controller coupled to the burner unit and the sensor. The controller includes an electronic processor and a memory. The controller is configured to receive a first signal corresponding to the characteristic from the sensor, determine, based on the first signal, a first feedback loop control, control combustion of the burner unit based on the first feedback loop control, determine, based on the first feedback loop control, a second feedback loop control, and control combustion of the burner unit based on the second feedback loop control.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: A fluid heating system including a burner unit is operated based on feedback control loops. The fluid heating system comprises a burner unit configured to heat a fluid, a sensor configured to sense a characteristic of the appliance, and a controller coupled to the burner unit and the sensor. The controller includes an electronic processor and a memory. The controller is configured to receive a first signal corresponding to the characteristic from the sensor, determine, based on the first signal, a first feedback loop control, control combustion of the burner unit based on the first feedback loop control, determine, based on the first feedback loop control, a second feedback loop control, and control combustion of the burner unit based on the second feedback loop control.

Abstract: This disclosure relates to a nucleic acid comprising a double stranded RNA molecule comprising sense and antisense strands and further comprising a single stranded DNA molecule covalently linked to the 3? end of either the sense or antisense RNA part of the molecule wherein the double stranded inhibitory RNA targets proprotein convertase subtilisin kexin type 9 (PCSK9); pharmaceutical compositions comprising said nucleic acid molecule and methods for the treatment of diseases associated with increased levels of PCSK9, for example hypercholesterolemia and cardiovascular disease.

Abstract: This disclosure relates to a nucleic acid comprising a double stranded RNA molecule comprising sense and antisense strands and further comprising a single stranded DNA molecule covalently linked to the 3? end of either the sense or antisense RNA part of the molecule wherein the double stranded inhibitory RNA targets apolipoprotein B in the treatment hypercholesterolemia.

Abstract: A fluid heating system including a burner unit is operated based on feedback control loops. The fluid heating system comprises a burner unit configured to heat a fluid, a sensor configured to sense a characteristic of the appliance, and a controller coupled to the burner unit and the sensor. The controller includes an electronic processor and a memory. The controller is configured to receive a first signal corresponding to the characteristic from the sensor, determine, based on the first signal, a first feedback loop control, control combustion of the burner unit based on the first feedback loop control, determine, based on the first feedback loop control, a second feedback loop control, and control combustion of the burner unit based on the second feedback loop control.

Abstract: This disclosure describes systems, methods, and devices related to linear regression models and machine learning models for generating vehicle prices. A device may receive information associated with a vehicle, information associated with a dealer selling the vehicle, and market information indicative of previous sales of similar vehicles. The device may generate probabilities of sale of the vehicle at respective price positions based on the information. The device may generate a price elasticity curve for the vehicle based on the probabilities of sale. The device may generate a vehicle score represented by a supply line that is associated with the vehicle based on the information. The device may identify a first intersection of the supply line and the price elasticity curve, generate a market rank based on the intersection, and generate a recommended price for the vehicle based on the market rank as an input to a machine learning model.

Abstract: The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: A method, system, apparatus, and/or device for threading a pipe may include: a housing including a cavity to store a pipe threading machine. The housing includes a door to open to provide access to the cavity and an opening along a side wall of the housing to receive an end of a pipe. The pipe threading machine located within the cavity. The pipe threading machine is to cut the pipe, ream the pipe, and thread the pipe using one or more attachments. An oiler is configured to apply oil to the pipe and the one or more attachments as the pipe threading machine cuts the pipe, reams the pipe, and threads the pipe. An oil catching system is located within the cavity below the oiler and the pipe threading machine to catch oil dripping or spraying from the pipe threading machine, the oiler, or the pipe.

Abstract: A hydronic water heating system heats water for various types of heat emitters. A boiler assembly includes a user interface which receives user-defined water temperature set point corresponding to a minimum outdoor temperature, and an integrated controller generates a nonlinear outdoor reset curve between the user-defined set point and a second set point corresponding to maximum outdoor temperature for which heating is required, and regulates the boiler to heat water to a temperature corresponding to a set point along the nonlinear output reset curve and based on a detected outdoor temperature. The nonlinear outdoor reset curve may be generated based on aggregated heat output functions for various types of heat emitters. A linear outdoor reset curve may be generated between a maximum water temperature set point and the user-defined set point, having a slope equal to an instantaneous slope of the nonlinear outdoor reset curve at the user-defined set point.

Abstract: The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Abstract: This disclosure describes systems, methods, and devices related to predictive modeling for evaluating vehicles. A device may receive vehicle information including a make, model, and year of a first vehicle. The device may determine a competitive set of vehicles that are of the same make, model, and year as the first vehicle, and that have with an odometer reading and a daily sale rate during a period of time. The device may determine, based on the odometer reading, an odometer-adjusted Cost to Market for the first vehicle. The device may determine, based on the daily sale rate during the period of time, a Market Day's Supply of the first vehicle. The device may determine, based on the Market Day's Supply and the odometer-adjusted Cost to Market, a vehicle score of the first vehicle. The device may send presentation data indicative of the vehicle score.

Abstract: The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.