Abstract: Some embodiments of the invention include a nucleic acid molecule comprising natural nucleotides, non-natural nucleotides, an LNA which comprises one or more RNA core molecules, or an RNA molecule which comprises more than one RNA core molecule. Some embodiments of the invention include a nucleic acid molecule comprising an RNA molecule which comprises more than one RNA core molecule. Other embodiments of the invention include a nucleic acid molecule comprising a DNA molecule encoding the RNA molecule (e.g., vector or viral vector). Other embodiments include compositions or pharmaceutical compositions that comprise the nucleic acid molecule. Some embodiments of the invention comprise reducing miR-143 in a cell. Other embodiments of the invention include methods to deliver a protein across the BBB. Other embodiments include methods for treating disease (e.g., LSD), neuronopathic disease, neurodegenerative disease, Hurler syndrome, or MPS I). Additional embodiments of the invention are also discussed herein.

Abstract: This application relates to a method, an apparatus, and a system of power line communication (PLC) for the internet of things (IoT). The method includes: A sending device receives a first request from a receiving device, where the first request requests to perform channel assessment in a first time window in a power line communication periodicity; in response to the first request, the sending device sends a sounding signal required for performing channel assessment to the receiving device; the sending device receives a modulation parameter from the receiving device, where the modulation parameter is determined by performing channel assessment based on the sounding signal; and the sending device performs data transmission with the receiving device in the first time window based on the modulation parameter.

Abstract: Some embodiments of the invention include a nucleic acid molecule comprising natural nucleotides, non-natural nucleotides, an LNA which comprises one or more RNA core molecules, or an RNA molecule which comprises more than one RNA core molecule. Some embodiments of the invention include a nucleic acid molecule comprising an RNA molecule which comprises more than one RNA core molecule. Other embodiments of the invention include a nucleic acid molecule comprising a DNA molecule encoding the RNA molecule (e.g., vector or viral vector). Other embodiments include compositions or pharmaceutical compositions that comprise the nucleic acid molecule. Some embodiments of the invention comprise reducing miR-143 in a cell. Other embodiments of the invention include methods to deliver a protein across the BBB. Other embodiments include methods for treating disease (e.g., LSD, neuronopathic disease, neurodegenerative disease, Hurler syndrome, or MPS I). Additional embodiments of the invention are also discussed herein.

Abstract: A PLC control method includes: transmit a first signal through a neutral wire and a path between the neutral wire and a differential signal processing circuit; transmit a second signal through a live wire and a path between the live wire and the differential signal processing circuit; and disconnecting the path between the differential signal processing circuit and the neutral wire or the live wire, conducting the differential signal processing circuit to a ground wire, and when a transmission rate of the ground wire is greater than or equal to a preset transmission rate threshold, transmitting the first signal or the second signal through the ground wire and a path between the ground wire and the differential signal processing circuit.

Abstract: This application provides a power line communication method. Wherein, a first node determines a channel status of a channel between a second node and the first node in an alternating current cycle. Then, the first node may divide the alternating current cycle into time windows based on the channel status, and determine modulation coding parameters used for data transmission between the second node and the first node in the time window obtained through division. Further, the first node may send information about the time window obtained through division and the modulation coding parameters used in the time window obtained through division to the second node.

Abstract: Methods for improving at least one neurological function in a subject that has or is suspected of having a neurologic lysosomal storage disorder using a rapamycin compound. Also provided herein are treatment of such a neurologic lysosomal storage disorder with the rapamycin compound.

Abstract: A PLC control method includes: transmit a first signal through a neutral wire and a path between the neutral wire and a differential signal processing circuit; transmit a second signal through a live wire and a path between the live wire and the differential signal processing circuit; and disconnecting the path between the differential signal processing circuit and the neutral wire or the live wire, conducting the differential signal processing circuit to a ground wire, and when a transmission rate of the ground wire is greater than or equal to a preset transmission rate threshold, transmitting the first signal or the second signal through the ground wire and a path between the ground wire and the differential signal processing circuit.

Abstract: This application provides a power line communication method. Wherein, a first node determines a channel status of a channel between a second node and the first node in an alternating current cycle. Then, the first node may divide the alternating current cycle into time windows based on the channel status, and determine modulation coding parameters used for data transmission between the second node and the first node in the time window obtained through division. Further, the first node may send information about the time window obtained through division and the modulation coding parameters used in the time window obtained through division to the second node.

Abstract: A network secure admission method, where, when determining that there is a home network device that needs to join a domain for pairing, a home network device used as a domain master node sends prompt information to a user. The user performs an authorization operation according to the prompt information sent by the domain master node. The domain master node receives the authorization operation of the user, enables a pairing window when determining that the authorization operation of the user is received, and sends, within an effective period of the pairing window, indication information used to indicate that the device is allowed to join the domain for pairing. After receiving the indication information sent by the domain master node, the device that needs to join the domain for pairing may initiate a registration request, to complete a secure admission process.

Abstract: Some embodiments of the invention include a nucleic acid molecule comprising natural nucleotides, non-natural nucleotides, an LNA which comprises one or more RNA core molecules, or an RNA molecule which comprises more than one RNA core molecule. Some embodiments of the invention include a nucleic acid molecule comprising an RNA molecule which comprises more than one RNA core molecule. Other embodiments of the invention include a nucleic acid molecule comprising a DNA molecule encoding the RNA molecule (e.g., vector or viral vector). Other embodiments include compositions or pharmaceutical compositions that comprise the nucleic acid molecule. Some embodiments of the invention comprise reducing miR-143 in a cell. Other embodiments of the invention include methods to deliver a protein across the BBB. Other embodiments include methods for treating disease (e.g., LSD, neuronopathic disease, neurodegenerative disease, Hurler syndrome, or MPS I). Additional embodiments of the invention are also discussed herein.

Abstract: Embodiments of the present disclosure provide an FEC coding and decoding method and device, and a system. A transmit end determines a forward error correction FEC coding type according to a length of to-be-coded data in burst data, and performs coding according to the determined FEC coding type. A receive end determines a forward error correction FEC decoding type according to a length of to-be-decoded data in burst data, and performs decoding according to the determined FEC decoding type. The FEC coding and decoding method provided in the embodiments of the present disclosure improves utilization of a communication resource is improved, and saves a communication resource.

Abstract: Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.

Abstract: A central access network unit comprising a processor configured to assign a plurality of upstream training blocks from an upstream OFDM symbol to a plurality of downstream network units, wherein the OFDM symbol comprises a plurality of pilot subcarriers equally spaced across an upstream RF spectrum in a pre-determined time interval, and wherein each upstream training block comprises a different subset of the pilot subcarriers that are non-consecutive and situated across the upstream RF spectrum, and generate one or more messages comprising assignments of the upstream training blocks, and a transmitter coupled to the processor and configured to transmit the messages to the plurality of downstream network units via a network, wherein the messages instruct at least one of the plurality of downstream network units to transmit a modulated pre-determined sequence at the pilot subcarriers corresponding to the upstream training block assigned to the downstream network unit.

Abstract: Embodiments of the present disclosure provide an FEC coding and decoding method and device, and a system. A transmit end determines a forward error correction FEC coding type according to a length of to-be-coded data in burst data, and performs coding according to the determined FEC coding type. A receive end determines a forward error correction FEC decoding type according to a length of to-be-decoded data in burst data, and performs decoding according to the determined FEC decoding type. The FEC coding and decoding method provided in the embodiments of the present disclosure improves utilization of a communication resource is improved, and saves a communication resource.

Abstract: A central access network unit comprising a processor configured to assign a plurality of upstream training blocks from an upstream OFDM symbol to a plurality of downstream network units, wherein the OFDM symbol comprises a plurality of pilot subcarriers equally spaced across an upstream RF spectrum in a pre-determined time interval, and wherein each upstream training block comprises a different subset of the pilot subcarriers that are non-consecutive and situated across the upstream RF spectrum, and generate one or more messages comprising assignments of the upstream training blocks, and a transmitter coupled to the processor and configured to transmit the messages to the plurality of downstream network units via a network, wherein the messages instruct at least one of the plurality of downstream network units to transmit a modulated pre-determined sequence at the pilot subcarriers corresponding to the upstream training block assigned to the downstream network unit.

Abstract: Embodiments of the present disclosure provide an FEC coding and decoding method and device, and a system. A transmit end determines a forward error correction FEC coding type according to a length of to-be-coded data in burst data, and performs coding according to the determined FEC coding type. A receive end determines a forward error correction FEC decoding type according to a length of to-be-decoded data in burst data, and performs decoding according to the determined FEC decoding type. The FEC coding and decoding method provided in the embodiments of the present disclosure improves utilization of a communication resource is improved, and saves a communication resource.

Abstract: An uplink signal scheduling method, a processing device, and a system. The method includes when uplink signals sent by at least one transmit device are received, preprocessing the uplink signals, to generate a data over cable service interface specification (DOCSIS) frame, where the DOCSIS frame includes at least two uplink signals, and each uplink signal of the at least two uplink signals corresponds to one uplink wavelength, and when it is detected that a signal conflict exists in the DOCSIS frame, creating at least two signal groups according to the uplink signals, and allocating, to the at least two signal groups, uplink signals that have a same uplink wavelength and cause the signal conflict, and performing scheduling on the uplink signals according to the signal groups that have undergone allocation.

Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.

Abstract: Embodiments of the present invention relate to the field of communications technologies, and disclose a resource reservation method and system, and a convergence device. The method includes: receiving, by a convergence device, a first resource reservation request message based on a format of a first interface and that is from a policy server (PS); converting, by the convergence device, the first resource reservation request message into a second resource reservation request message based on a format of a second interface; and sending, by the convergence device, the second resource reservation request message based on the format of the second interface to a modulation and demodulation system, so that the modulation and demodulation system performs resource reservation according to the second resource reservation request message.

Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.