Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.

Abstract: A central access network unit comprising a processor configured to assign a plurality of upstream training blocks from an upstream OFDM symbol to a plurality of downstream network units, wherein the OFDM symbol comprises a plurality of pilot subcarriers equally spaced across an upstream RF spectrum in a pre-determined time interval, and wherein each upstream training block comprises a different subset of the pilot subcarriers that are non-consecutive and situated across the upstream RF spectrum, and generate one or more messages comprising assignments of the upstream training blocks, and a transmitter coupled to the processor and configured to transmit the messages to the plurality of downstream network units via a network, wherein the messages instruct at least one of the plurality of downstream network units to transmit a modulated pre-determined sequence at the pilot subcarriers corresponding to the upstream training block assigned to the downstream network unit.

Abstract: A central access network unit comprising a processor configured to assign a plurality of upstream training blocks from an upstream OFDM symbol to a plurality of downstream network units, wherein the OFDM symbol comprises a plurality of pilot subcarriers equally spaced across an upstream RF spectrum in a pre-determined time interval, and wherein each upstream training block comprises a different subset of the pilot subcarriers that are non-consecutive and situated across the upstream RF spectrum, and generate one or more messages comprising assignments of the upstream training blocks, and a transmitter coupled to the processor and configured to transmit the messages to the plurality of downstream network units via a network, wherein the messages instruct at least one of the plurality of downstream network units to transmit a modulated pre-determined sequence at the pilot subcarriers corresponding to the upstream training block assigned to the downstream network unit.

Abstract: An apparatus comprising a receiver configured to couple to an Ethernet Passive Optical network over Coaxial (EPoC) network, and receive an upstream Orthogonal Frequency Division Multiplexing (OFDM) signal comprising a plurality of OFDM Resource Elements (REs), and a processor coupled to the receiver and configured to determine a presence of a burst marker sequence in the received signal, wherein the burst marker sequence comprises interlaced pilot symbols and null symbols, and wherein determining the presence of the burst marker sequence comprises computing a power ratio between a first set of the OFDM REs and a second set of the OFDM REs, and determining that the burst marker sequence is found when the computed power ratio exceeds a pre-determined threshold.

Abstract: A Cable Modem Termination System (CMTS) comprising a receiver configured to receive a plurality of upstream transmission request messages from a plurality of coaxial units via an electro-optical network, wherein the upstream transmission request messages each request permission to transmit a specified amount of data, a processor coupled to the receiver and configured to allocate Orthogonal Frequency-Division Multiplexing (OFDM) minislots to each coaxial unit based on the amount of data requested in the associated upstream transmission request message, and a transmitter coupled to the processor and configured to transmit at least one Uplink Allocation Map (UL-MAP) message to indicate minislot allocations to the coaxial units.

Abstract: An uplink signal scheduling method, a processing device, and a system. The method includes when uplink signals sent by at least one transmit device are received, preprocessing the uplink signals, to generate a data over cable service interface specification (DOCSIS) frame, where the DOCSIS frame includes at least two uplink signals, and each uplink signal of the at least two uplink signals corresponds to one uplink wavelength, and when it is detected that a signal conflict exists in the DOCSIS frame, creating at least two signal groups according to the uplink signals, and allocating, to the at least two signal groups, uplink signals that have a same uplink wavelength and cause the signal conflict, and performing scheduling on the uplink signals according to the signal groups that have undergone allocation.

Abstract: A method implemented in a Fiber Coaxial Unit (FCU) comprising receiving a plurality of Ethernet Passive Optical Network (EPON) report messages from a plurality of Coaxial Network Units (CNUs) across a coaxial network, receiving an EPON gate message comprising Time Quanta (TQ) information indicating an upstream transmission time grant for the FCU across the optical network, translating the TQ based upstream transmission time grants to OFDM resource block grants in a time domain and in a frequency domain across the coaxial network for each CNU based on the configurable constants, and transmitting an EPON over Coaxial (EPoC) gate message to each CNU, wherein each EPoC gate message comprises a CNU profile indicating the Orthogonal Frequency-Division Multiplexing (OFDM) resource block grants for the an associated CNU and a start time.

Abstract: An apparatus for communication. A headend supports a plurality of customer premises equipment (CPEs) in a cable service network. An NCP carrier selector selects at least one orthogonal frequency division multiplex (OFDM) subcarrier taken from a radio frequency (RF) spectrum available for broadcasting signals over the cable service network using a plurality of profiles, wherein each selected OFDM subcarrier comprises a corresponding bit loading for each supported profile that meets or exceeds a minimum number of bits used for delivering next codeword pointer (NCP) messages that is acceptable for each of a plurality of profiles used in the plurality of CPEs for receiving signals over the cable service network. A profile generator generates an NCP profile identifying one or more selected OFDM subcarriers, wherein the NCP profile indicates which OFDM subcarriers within the RF spectrum are usable to carry NCP messages, and an associated bit loading for each selected subcarrier.

Abstract: Embodiments of the present disclosure provide an FEC coding and decoding method and device, and a system. A transmit end determines a forward error correction FEC coding type according to a length of to-be-coded data in burst data, and performs coding according to the determined FEC coding type. A receive end determines a forward error correction FEC decoding type according to a length of to-be-decoded data in burst data, and performs decoding according to the determined FEC decoding type. The FEC coding and decoding method provided in the embodiments of the present disclosure improves utilization of a communication resource is improved, and saves a communication resource.

Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.

Abstract: Embodiments of the present invention relate to the field of communications technologies, and disclose a resource reservation method and system, and a convergence device. The method includes: receiving, by a convergence device, a first resource reservation request message based on a format of a first interface and that is from a policy server (PS); converting, by the convergence device, the first resource reservation request message into a second resource reservation request message based on a format of a second interface; and sending, by the convergence device, the second resource reservation request message based on the format of the second interface to a modulation and demodulation system, so that the modulation and demodulation system performs resource reservation according to the second resource reservation request message.

Abstract: An apparatus for communication. A headend supports a plurality of customer premises equipment (CPEs) in a cable service network. An NCP carrier selector selects at least one orthogonal frequency division multiplex (OFDM) subcarrier taken from a radio frequency (RF) spectrum available for broadcasting signals over the cable service network using a plurality of profiles, wherein each selected OFDM subcarrier comprises a corresponding bit loading for each supported profile that meets or exceeds a minimum number of bits used for delivering next codeword pointer (NCP) messages that is acceptable for each of a plurality of profiles used in the plurality of CPEs for receiving signals over the cable service network. A profile generator generates an NCP profile identifying one or more selected OFDM subcarriers, wherein the NCP profile indicates which OFDM subcarriers within the RF spectrum are usable to carry NCP messages, and an associated bit loading for each selected subcarrier.

Abstract: A Cable Modem Termination System (CMTS) comprising a receiver configured to receive a plurality of upstream transmission request messages from a plurality of coaxial units via an electro-optical network, wherein the upstream transmission request messages each request permission to transmit a specified amount of data, a processor coupled to the receiver and configured to allocate Orthogonal Frequency-Division Multiplexing (OFDM) minislots to each coaxial unit based on the amount of data requested in the associated upstream transmission request message, and a transmitter coupled to the processor and configured to transmit at least one Uplink Allocation Map (UL-MAP) message to indicate minislot allocations to the coaxial units.

Abstract: An apparatus comprising a receiver configured to couple to an Ethernet Passive Optical network over Coaxial (EPoC) network, and receive an upstream Orthogonal Frequency Division Multiplexing (OFDM) signal comprising a plurality of OFDM Resource Elements (REs), and a processor coupled to the receiver and configured to determine a presence of a burst marker sequence in the received signal, wherein the burst marker sequence comprises interlaced pilot symbols and null symbols, and wherein determining the presence of the burst marker sequence comprises computing a power ratio between a first set of the OFDM REs and a second set of the OFDM REs, and determining that the burst marker sequence is found when the computed power ratio exceeds a pre-determined threshold.

Abstract: A method implemented in a Fiber Coaxial Unit (FCU) comprising receiving a plurality of Ethernet Passive Optical Network (EPON) report messages from a plurality of Coaxial Network Units (CNUs) across a coaxial network, receiving an EPON gate message comprising Time Quanta (TQ) information indicating an upstream transmission time grant for the FCU across the optical network, translating the TQ based upstream transmission time grants to OFDM resource block grants in a time domain and in a frequency domain across the coaxial network for each CNU based on the configurable constants, and transmitting an EPON over Coaxial (EPoC) gate message to each CNU, wherein each EPoC gate message comprises a CNU profile indicating the Orthogonal Frequency-Division Multiplexing (OFDM) resource block grants for the an associated CNU and a start time.

Abstract: A central access network unit comprising a processor configured to assign a plurality of upstream training blocks from an upstream OFDM symbol to a plurality of downstream network units, wherein the OFDM symbol comprises a plurality of pilot subcarriers equally spaced across an upstream RF spectrum in a pre-determined time interval, and wherein each upstream training block comprises a different subset of the pilot subcarriers that are non-consecutive and situated across the upstream RF spectrum, and generate one or more messages comprising assignments of the upstream training blocks, and a transmitter coupled to the processor and configured to transmit the messages to the plurality of downstream network units via a network, wherein the messages instruct at least one of the plurality of downstream network units to transmit a modulated pre-determined sequence at the pilot subcarriers corresponding to the upstream training block assigned to the downstream network unit.

Abstract: Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.

Abstract: Embodiments of the present invention provide a method, an apparatus, and a system for multiple access. The method includes: receiving, by a network device, a data packet, where the data packet includes identifier information about a terminal; querying, according to the identifier information about the terminal, a correspondence table between identifier information about a terminal and a broadcast channel, and determining a broadcast channel corresponding to the identifier information about the terminal, where the determined broadcast channel is a broadcast channel among a plurality of preset broadcast channels, and the terminal is any terminal in a terminal group corresponding to the determined broadcast channel; and sending, according to the identifier information about the terminal, through the determined broadcast channel, the data packet to the terminal.

Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.