Patents by Inventor Daqing Wu
Daqing Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124512Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.Type: ApplicationFiled: September 28, 2023Publication date: April 18, 2024Inventors: Xiaohui DU, John EKSTEROWICZ, Valeria R. FANTIN, Daqing SUN, Qiuping YE, Jared MOORE, Tatiana ZAVOROTINSKAYA, Brian R. BLANK, Yosup REW, Kejia WU, Liusheng ZHU, Johnny PHAM, Hiroyuki KAWAI
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Patent number: 11945181Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10h?) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10h??20)° C. to about T10h?° C. for a first curing time and maintaining a second curing temperature of from about (T10h?+10)° C. to about (T10h?+35)° C. for a second curing time.Type: GrantFiled: October 27, 2021Date of Patent: April 2, 2024Assignee: Alcon Inc.Inventors: Junhao Ge, Yuan Chang, Steve Yun Zhang, Michelle Plavnik, Augustine Twum Kumi, Daqing Wu
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Patent number: 11931454Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.Type: GrantFiled: September 17, 2020Date of Patent: March 19, 2024Assignee: Alcon Inc.Inventors: Junhao Ge, Steve Yun Zhang, Daqing Wu, Jing Cheng
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Publication number: 20240018309Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 12, 2023Publication date: January 18, 2024Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11802182Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: May 12, 2022Date of Patent: October 31, 2023Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20230158760Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a watersoluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: November 21, 2022Publication date: May 25, 2023Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20230103231Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.Type: ApplicationFiled: August 31, 2022Publication date: March 30, 2023Inventors: Daqing Wu, Feng Jing, Steve Yun Zhang, Junhao Ge, Jack W. Trieu
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Patent number: 11542353Abstract: The invention provides a method for producing photochromic silicone hydrogel (SiHy) contact lenses based on thermal cast-molding technology in a relatively efficient and consistent manner. The method is characterized by selecting a high radical-reactive hydrophilic acrylic monomer while eliminating any low radical-reactive hydrophilic N-vinyl amide monomer in a lens formulation (polymerizable composition), by selecting a weight ratio of low-radical-reactive hydrophilic N-vinyl amide monomer to a high radical-reactive hydrophilic acrylic monomer in a lens formulation if the low radical-reactive hydrophilic N-vinyl amide monomer is needed, and/or by using a relatively high temperature thermal initiator in a lens formulation, to control the lens properties (e.g., water content, elastic modulus, etc.) and lens processability (capability of dry-delensing from molds) of thermally cast-molded SiHy contact lenses while minimizing loss in photochromic ability of resultant SiHy contact lenses.Type: GrantFiled: May 12, 2020Date of Patent: January 3, 2023Assignee: Alcon Inc.Inventors: Weihong Lang, Junhao Ge, Steve Yun Zhang, Daqing Wu
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Patent number: 11534994Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: January 11, 2021Date of Patent: December 27, 2022Assignee: Alcon Inc.Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 11439661Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.Type: GrantFiled: June 25, 2020Date of Patent: September 13, 2022Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Richard Charles Breitkopf, Daqing Wu, Junhao Ge, Maria F. Gubitosi Raspino, Augustine Twum Kumi, Wei Liang
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Patent number: 11433629Abstract: The invention provides a contact lens manufacturing method for cast-molding of silicone hydrogel contact lenses having enhanced oxygen permeability without adversely affecting desirable lens mechanical properties (e.g., modulus). A method of the invention comprises adding a small amount of a radical scavenger (e.g., H-TEMPO) in a polymerizable composition for cast-molding of SiHy contact lenses) to provide the resultant polymerizable composition with a bi-phase curing profile at a curing temperature of from about 45° C. to about 100° C. With such a bi-phase curing profile, the resultant polymerizable composition can be thermally cured at the curing temperature to form a SiHy contact lens having an oxygen permeability higher than that for a polymerizable composition having the substantially identical composition excepting being free of any radical scavenger.Type: GrantFiled: June 3, 2019Date of Patent: September 6, 2022Assignee: Alcon Inc.Inventors: Weihong Lang, Wei Liang, Ying Zheng, Karen Belinda Sentell, Richard Charles Breitkopf, Daqing Wu, Steve Yun Zhang
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Publication number: 20220275154Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: May 12, 2022Publication date: September 1, 2022Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11427685Abstract: The invention provides a method for making silicone hydrogel contact lenses. The method of the invention is characterized by using an organic solvent as a processing-aid tool for controlling lens diameter without significantly affecting lens equilibrium water content during cast-molding of soft contact lenses from a polymerizable composition. By adjusting the weight percentage of the organic solvent in a polymerizable composition for making SiHy contact lenses, one can adjust lens diameter of produced SiHy lenses to meet target without affecting adversely the lens properties.Type: GrantFiled: March 27, 2019Date of Patent: August 30, 2022Assignee: Alcon Inc.Inventors: Daqing Wu, Steve Yun Zhang, Junhao Ge, Richard Charles Breitkopf, Augustine Twum Kumi, Weihong Lang
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Patent number: 11365288Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: September 30, 2020Date of Patent: June 21, 2022Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 11346982Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: September 30, 2020Date of Patent: May 31, 2022Assignee: Alcon Inc.Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20220126541Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10h?) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10h??20)° C. to about T10h?° C. for a first curing time and maintaining a second curing temperature of from about (T10h?+10)° C. to about (T10h?+35)° C. for a second curing time.Type: ApplicationFiled: October 27, 2021Publication date: April 28, 2022Inventors: Junhao Ge, Yuan Chang, Steve Yun Zhang, Michelle Plavnik, Augustine Twum Kumi, Daqing Wu
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Patent number: 11254076Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprising the steps of formulating a lens formulation by dissolving/blending all polymerizable components in a mixture a hydrophobic acrylic monomer as a reactive diluent and an organic solvent as a non-reactive diluent at a weight ratio of least 0.24 (reactive diluent over the sum of reactive and non-reactive solvents) per gram of the polymerizable composition and using a relatively low ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.Type: GrantFiled: June 3, 2019Date of Patent: February 22, 2022Assignee: Alcon Inc.Inventors: Junhao Ge, Daqing Wu, Richard Charles Breitkopf, Steve Yun Zhang, Augustine Twum Kumi
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Patent number: 11254075Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprises the combination of using a hydrophilic (meth)acrylamido monomer as one of major polymerizable components in a lens formulation for cast-molding of contact lenses, adding a post-curing treatment step which involves heating molds with molded lenses therewithin in an oven at a post-curing temperature higher than the curing temperature and under nitrogen gas flow at a higher flow rate, and using ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.Type: GrantFiled: June 3, 2019Date of Patent: February 22, 2022Assignee: Alcon Inc.Inventors: Richard Charles Breitkopf, Daqing Wu, Junhao Ge, Steve Yun Zhang
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Publication number: 20220047503Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.Type: ApplicationFiled: August 3, 2021Publication date: February 17, 2022Inventors: Junhao Ge, Steve Yun Zhang, Daqing Wu, Jing Cheng, Yuan Chang, Feng Jing, Jang-Shing Chiou, Stephen Raymond Perreault
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Publication number: 20220047502Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.Type: ApplicationFiled: August 3, 2021Publication date: February 17, 2022Inventors: Jing Cheng, Stephen Raymond Perreault, Daqing Wu, Steve Yun Zhang, Jang-Shing Chiou