Patents by Inventor Daqing Wu
Daqing Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210130648Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: January 11, 2021Publication date: May 6, 2021Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 10968319Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.Type: GrantFiled: February 21, 2019Date of Patent: April 6, 2021Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Maria F. Gubitosi Raspino, Richard Charles Breitkopf, Daqing Wu, Junhao Ge, Augustine Twum Kumi, Zach Munoz, Weihong Lang
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Patent number: 10962803Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.Type: GrantFiled: January 29, 2019Date of Patent: March 30, 2021Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Richard Charles Breitkopf, Weihong Lang, Junhao Ge, Maria F. Gubitosi Raspino, Frank Chang, Thomas M. Moy, Troy Vernon Holland
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Publication number: 20210077385Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.Type: ApplicationFiled: September 17, 2020Publication date: March 18, 2021Inventors: Junhao Ge, Steve Yun Zhang, Daqing Wu, Jing Cheng
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Patent number: 10920102Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: December 19, 2019Date of Patent: February 16, 2021Assignee: Alcon Inc.Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20210009762Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 30, 2020Publication date: January 14, 2021Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20210011197Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: ApplicationFiled: September 30, 2020Publication date: January 14, 2021Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Publication number: 20200405747Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.Type: ApplicationFiled: June 25, 2020Publication date: December 31, 2020Inventors: Steve Yun Zhang, Richard Charles Breitkopf, Daqing Wu, Junhao Ge, Maria F. Gubitosi Raspino, Augustine Twum Kumi, Wei Liang
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Patent number: 10875967Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: June 6, 2018Date of Patent: December 29, 2020Assignee: Alcon Inc.Inventors: Steve Yun Zhang, Daqing Wu, Junhao Ge, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 10866344Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.Type: GrantFiled: June 6, 2018Date of Patent: December 15, 2020Assignee: Alcon Inc.Inventors: Daqing Wu, Junhao Ge, Steve Yun Zhang, Richard Charles Breitkopf, Xinming Qian, Zach Munoz, Matthew D. Nelson, Augustine Twum Kumi, Weihong Lang, Ying Zheng, Feng Jing, Frank Chang
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Patent number: 10843422Abstract: The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.Type: GrantFiled: June 6, 2018Date of Patent: November 24, 2020Assignee: Alcon, Inc.Inventors: Daqing Wu, Steve Yun Zhang, Xinming Qian, Zach Munoz, Frank Chang, Wei Liang, Ying Zheng, Richard Charles Breitkopf, Matthew D. Nelson, Augustine Twum Kumi
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Publication number: 20200362082Abstract: The invention provides a method for producing photochromic silicone hydrogel (SiHy) contact lenses based on thermal cast-molding technology in a relatively efficient and consistent manner. The method is characterized by selecting a high radical-reactive hydrophilic acrylic monomer while eliminating any low radical-reactive hydrophilic N-vinyl amide monomer in a lens formulation (polymerizable composition), by selecting a weight ratio of low-radical-reactive hydrophilic N-vinyl amide monomer to a high radical-reactive hydrophilic acrylic monomer in a lens formulation if the low radical-reactive hydrophilic N-vinyl amide monomer is needed, and/or by using a relatively high temperature thermal initiator in a lens formulation, to control the lens properties (e.g., water content, elastic modulus, etc.) and lens processability (capability of dry-delensing from molds) of thermally cast-molded SiHy contact lenses while minimizing loss in photochromic ability of resultant SiHy contact lenses.Type: ApplicationFiled: May 12, 2020Publication date: November 19, 2020Inventors: Weihong Lang, Junhao Ge, Steve Yun Zhang, Daqing Wu
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Publication number: 20200157378Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: December 19, 2019Publication date: May 21, 2020Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Patent number: 10563090Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: GrantFiled: April 29, 2019Date of Patent: February 18, 2020Assignee: Novartis AGInventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson
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Publication number: 20190366658Abstract: The invention provides a contact lens manufacturing method for cast-molding of silicone hydrogel contact lenses having enhanced oxygen permeability without adversely affecting desirable lens mechanical properties (e.g., modulus). A method of the invention comprises adding a small amount of a radical scavenger (e.g., H-TEMPO) in a polymerizable composition for cast-molding of SiHy contact lenses) to provide the resultant polymerizable composition with a bi-phase curing profile at a curing temperature of from about 45° C. to about 100° C. With such a bi-phase curing profile, the resultant polymerizable composition can be thermally cured at the curing temperature to form a SiHy contact lens having an oxygen permeability higher than that for a polymerizable composition having the substantially identical composition excepting being free of any radical scavenger.Type: ApplicationFiled: June 3, 2019Publication date: December 5, 2019Inventors: Weihong Lang, Wei Liang, Ying Zheng, Karen Belinda Sentell, Richard Charles Breitkopf, Daqing Wu, Steve Yun Zhang
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Publication number: 20190366660Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprising the steps of formulating a lens formulation by dissolving/blending all polymerizable components in a mixture a hydrophobic acrylic monomer as a reactive diluent and an organic solvent as a non-reactive diluent at a weight ratio of least 0.24 (reactive diluent over the sum of reactive and non-reactive solvents) per gram of the polymerizable composition and using a relatively low ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.Type: ApplicationFiled: June 3, 2019Publication date: December 5, 2019Inventors: Junhao Ge, Daqing Wu, Richard Charles Breitkopf, Steve Yun Zhang, Augustine Twum Kumi
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Publication number: 20190366659Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprises the combination of using a hydrophilic (meth)acrylamido monomer as one of major polymerizable components in a lens formulation for cast-molding of contact lenses, adding a post-curing treatment step which involves heating molds with molded lenses therewithin in an oven at a post-curing temperature higher than the curing temperature and under nitrogen gas flow at a higher flow rate, and using ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.Type: ApplicationFiled: June 3, 2019Publication date: December 5, 2019Inventors: Richard Charles Breitkopf, Daqing Wu, Junhao Ge, Steve Yun Zhang
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Patent number: 10485633Abstract: The present invention provides an improved root canal filling point/cone that can be manufactured precisely to result in better obturation with less micro-leakage. One aspect of the present invention is directed to a molded root canal filling point/cone. Another aspect of the present invention is directed to a thermo-pressure molding process for manufacturing root canal filing appliances (e.g., Gutta Percha points). Another aspect of the present invention is directed to the structure of the mold for undertaking thermo-injection molding. A further aspect of the present invention is directed to a production line comprising the thermo-injection process.Type: GrantFiled: February 14, 2014Date of Patent: November 26, 2019Inventors: Nathan Y. Li, DaQing Wu
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Patent number: 10449740Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.Type: GrantFiled: December 13, 2016Date of Patent: October 22, 2019Assignee: Novartis AGInventors: Xinming Qian, Jared Nelson, Robert Carey Tucker, Steve Yun Zhang, Daqing Wu, Leroy Wainaina Muya, Dharmesh Patel, Zach Munoz, Yongxing Qiu, Chung-Yuan Chiang, Ritu Shrestha, Kelly Kayi Tallau
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Publication number: 20190309188Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.Type: ApplicationFiled: April 29, 2019Publication date: October 10, 2019Inventors: Yongxing Qiu, Newton T. Samuel, John Dallas Pruitt, Chandana Kolluru, Arturo Norberto Medina, Lynn Cook Winterton, Daqing Wu, Xinming Qian, Jared Nelson