Patents by Inventor Darrell J. Irvine

Darrell J. Irvine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FERRITIN NANOPARTICLE DISPLAYING AN HIV TRIMER
    Publication number: 20210363194
    Abstract: The present invention relates to glycosylate HIV timer nanoparticles fused to self-assembling ferritin proteins which may be utilized as immunogens to enhance trafficking to lymph nodes and germinal centers and to heighten immune responses.
    Type: Application
    Filed: June 5, 2019
    Publication date: November 25, 2021
    Inventors: Talar Tokatlian, Benjamin J. Read, Daniel W. Kulp, Sergey Menis, Jon M. Steichen, William R. Schief, Darrell J. Irvine
  • CHIMERIC ANTIGEN RECEPTOR-TARGETING LIGANDS AND USES THEREOF
    Publication number: 20210338833
    Abstract: The disclosure features chimeric antigen receptor (CAR) ligands, methods for making the same, and immunomodulatory compositions comprising the CAR ligands. The disclosure also features compositions and methods of using the immunomodulatory compositions, for example, to stimulate activation of CAR expressing cells.
    Type: Application
    Filed: March 1, 2021
    Publication date: November 4, 2021
    Inventors: Darrell J. IRVINE, Karl Dane WITTRUP, Naveen MEHTA, Leyuan MA, Benjamin COSSETTE
  • METHODS FOR IDENTIFYING CHIMERIC ANTIGEN RECEPTOR-TARGETING LIGANDS AND USES THEREOF
    Publication number: 20210340524
    Abstract: The disclosure features chimeric antigen receptor (CAR) ligands, methods for making the same, and immunomodulatory compositions comprising the CAR ligands. The disclosure also features compositions and methods of using the immunomodulatory compositions, for example, to stimulate activation of CAR expressing cells.
    Type: Application
    Filed: March 1, 2021
    Publication date: November 4, 2021
    Inventors: Darrell J. IRVINE, Karl Dane WITTRUP, Naveen MEHTA, Leyuan MA, Benjamin COSSETTE
  • ALBUMIN BINDING PEPTIDE CONJUGATES AND METHODS THEREOF
    Publication number: 20210330800
    Abstract: The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
    Type: Application
    Filed: July 9, 2021
    Publication date: October 28, 2021
    Inventors: Kelly Dare MOYNIHAN, Rebecca Lynn HOLDEN, Darrell J. IRVINE, Bradley Lether PENTELUTE
  • CONTROL OF REPLICATION AND TRANSCRIPTION OF SELF-REPLICATING RNA IN RESPONSE TO SMALL MOLECULES
    Publication number: 20210324413
    Abstract: Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Yingzhong Li, Jan Lonzaric, Parisa Yousefpour
  • HIV-1 SPECIFIC IMMUNOGEN COMPOSITIONS AND METHODS OF USE
    Publication number: 20210317192
    Abstract: Disclosed herein are methods and compositions for treating a subject having or at risk of having an HIV infection. Disclosed herein are peptide immunogens and nucleic acids that have epitopes in which mutations are most likely to have deleterious effects on the HIV virus. An algorithm is disclosed for the selection of the epitopes based on the HIV fitness landscape, and it accounts for the effect of coupling mutations.
    Type: Application
    Filed: May 29, 2020
    Publication date: October 14, 2021
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Darrell J. Irvine, Dan H. Barouch, Arup K. Chakraborty, Dariusz Murakowski, Bruce D. Walker, John Barton, Andrew Ferguson
  • CELL SURFACE COUPLING OF NANOPARTICLES
    Publication number: 20210269500
    Abstract: The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 2, 2021
    Inventors: Darrell J. IRVINE, Yiran ZHENG, Li TANG
  • METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY
    Publication number: 20210259968
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Application
    Filed: October 13, 2020
    Publication date: August 26, 2021
    Inventors: Darrell J. IRVINE, Matthias STEPHAN, Jaehyun MOON, Anna BERSHTEYN
  • Albumin binding peptide conjugates and methods thereof
    Patent number: 11077199
    Abstract: The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: August 3, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Kelly Dare Moynihan, Rebecca Lynn Holden, Darrell J. Irvine, Bradley Lether Pentelute
  • Cell surface coupling of nanoparticles
    Patent number: 11034752
    Abstract: The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: June 15, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Darrell J. Irvine, Yiran Zheng, Li Tang
  • Lipid nanoparticles and use thereof to deliver RNA polynucleotides
    Patent number: 11026894
    Abstract: Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: June 8, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Tasuku Kitada, Mariane Melo, Yuan Zhang
  • Methods of treating cancer cells expressing tumor-associated integrins
    Patent number: 10888603
    Abstract: The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), an integrin-binding-Fc fusion protein, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 12, 2021
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of Technology
    Inventors: Karl Dane Wittrup, Darrell J. Irvine, Cary Francis Opel, Kelly Dare Moynihan, Jennifer R. Cochran, Byron Hua Kwan
  • IMMUNOMODULATORY FUSION PROTEIN-METAL HYDROXIDE COMPLEXES AND METHODS THEREOF
    Publication number: 20200405850
    Abstract: The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.
    Type: Application
    Filed: April 24, 2020
    Publication date: December 31, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. IRVINE, Karl Dane WITTRUP, Tyson MOYER, Yash AGARWAL
  • HIV-1 SPECIFIC IMMUNOGEN COMPOSITIONS AND METHODS OF USE
    Publication number: 20200377576
    Abstract: Disclosed herein are methods and compositions for treating a subject having or at risk of having an HIV infection. Disclosed herein are peptide immunogens and nucleic acids that have epitopes in which mutations are most likely to have deleterious effects on the HIV virus. An algorithm is disclosed for the selection of the epitopes based on the HIV fitness landscape, and it accounts for the effect of coupling mutations.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Darrell J. Irvine, Dan H. Barouch, Arup K. Chakraborty, Dariusz Murakowski, Bruce D. Walker, John Barton, Andrew Ferguson
  • PEPTIDE NUCLEIC ACID FUNCTIONALIZED HYDROGEL MICRONEEDLES FOR SAMPLING AND DETECTION OF INTERSTITIAL FLUID NUCLEIC ACIDS
    Publication number: 20200377929
    Abstract: The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Inventors: Darrell J. Irvine, Jason Y.H. Chang, Sylvain Ladame, Dana Al Sulaiman
  • CARRIER-FREE BIOLOGICALLY-ACTIVE PROTEIN NANOSTRUCTURES
    Publication number: 20200360482
    Abstract: The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
    Type: Application
    Filed: February 19, 2020
    Publication date: November 19, 2020
    Inventors: Li TANG, Darrell J. IRVINE
  • USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR
    Publication number: 20200345853
    Abstract: Provided herein are methods for stimulating an immune response to a target cell population or a target tissue in a subject by administering to the subject a composition comprising an amphiphilic ligand conjugate. Such an amphiphilic ligand conjugate can comprise a lipid, one or more cargos (e.g., a CAR ligand, a chimeric cytokine receptor target, a chimeric co-stimulation receptor target, a synNotch receptor target), and optionally a linker.
    Type: Application
    Filed: March 20, 2020
    Publication date: November 5, 2020
    Inventors: Darrell J. IRVINE, Peter C. DEMUTH
  • SYNTHETIC ONCOLYTIC LNP-REPLICON RNA AND USES FOR CANCER IMMUNOTHERAPY
    Publication number: 20200281994
    Abstract: The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
    Type: Application
    Filed: January 10, 2020
    Publication date: September 10, 2020
    Applicants: Massachusetts Institute of Technology, The Ohio State University
    Inventors: Darrell J. Irvine, Karl Dane Wittrup, Ron Weiss, Yingzhong Li, Noor Momin, Yizhou Dong
  • COMPOSITIONS FOR CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY AND USES THEREOF
    Publication number: 20200230221
    Abstract: The disclosure describes amphiphilic ligand conjugates comprising a chimeric antigen receptor (CAR) ligand, a lipid (diacyl lipid), a linker (hydrophilic polymers, hydrophilic amino acids, polysaccharides), compositions and methods of using the constructs are claimed, for example, to stimulate proliferation of CAR expressing cells.
    Type: Application
    Filed: September 19, 2018
    Publication date: July 23, 2020
    Inventors: Darrell J. IRVINE, Leyuan MA
  • COMBINATION IMMUNOTHERAPY DOSING REGIMEN FOR IMMUNE CHECKPOINT BLOCKADE
    Publication number: 20200230208
    Abstract: The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.
    Type: Application
    Filed: November 22, 2019
    Publication date: July 23, 2020
    Inventors: Chensu WANG, Karl Dane WITTRUP, Darrell J. IRVINE