Patents by Inventor Darrell J. Irvine

Darrell J. Irvine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid vesicle compositions and methods of use
    Patent number: 9907753
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: March 6, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • SYNTHETIC NANOPARTICLES FOR DELIVERY OF IMMUNOMODULATORY COMPOUNDS
    Publication number: 20180015174
    Abstract: The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of cancers and infectious diseases.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 18, 2018
    Inventors: Darrell J. IRVINE, Eric DANE
  • LIPID VESICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20170266114
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 21, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Lipid vesicle compositions and methods of use
    Patent number: 9750803
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: September 5, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Method and apparatus for tracking cell identity
    Patent number: 9709479
    Abstract: A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtiter plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: July 18, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Marc Castellarnau, Gregory Lee Szeto, Darrell J. Irvine, John Christopher Love, Joel Voldman
  • CARRIER-FREE BIOLOGICALLY-ACTIVE PROTEIN NANOSTRUCTURES
    Publication number: 20170196938
    Abstract: The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 13, 2017
    Inventors: Li TANG, Darrell J. IRVINE
  • Artificial immune system: methods of use
    Patent number: 9625444
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 18, 2017
    Assignees: SANOFI PASTEUR VAXDESIGN CORPORATION, THE SCRIPPS RESEARCH INSTITUTE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Hacohen, Bruce Torbett
  • Lipid vesicle compositions and methods of use
    Patent number: 9616020
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: April 11, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Carrier-free biologically-active protein nanostructures
    Patent number: 9603944
    Abstract: The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 28, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Li Tang, Darrell J. Irvine
  • CELL SURFACE COUPLING OF NANOPARTICLES
    Publication number: 20170080104
    Abstract: The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.
    Type: Application
    Filed: August 12, 2016
    Publication date: March 23, 2017
    Inventors: Darrell J. IRVINE, Yiran ZHENG, Li Tang
  • LIPID VESICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20170049882
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 23, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • IN VIVO TARGETING OF CELLS WITH LIGAND-CONJUGATED PARTICLES
    Publication number: 20160375149
    Abstract: The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest over a period of time.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Inventors: Darrell J. IRVINE, Yiran ZHENG, Yuan ZHANG, Brandon KWONG
  • LIPID VESICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20160303046
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Application
    Filed: April 13, 2016
    Publication date: October 20, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Lipid vesicle compositions and methods of use
    Patent number: 9445994
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • METHODS AND COMPOSITIONS FOR LOCALIZED AGENT DELIVERY
    Publication number: 20160256386
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Application
    Filed: February 4, 2016
    Publication date: September 8, 2016
    Inventors: Darrell J. IRVINE, Matthias STEPHAN, Jaehyun MOON, Anna BERSHTEYN
  • Methods and compositions for localized delivery of agents to virally infected cells and tissues
    Patent number: 9415070
    Abstract: The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy of T lymphocytes.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 16, 2016
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Darrell J. Irvine, Bruce D. Walker, Richard Bradley Jones
  • Methods and compositions for localized agent delivery
    Patent number: 9393199
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: July 19, 2016
    Assignee: Massachusetts Institute Of Technology
    Inventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
  • Lipid vesicle compositions and methods of use
    Patent number: 9339462
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: May 17, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon
  • Methods and compositions for localized agent delivery
    Patent number: 9283184
    Abstract: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 15, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Matthias Stephan, Jaehyun Moon, Anna Bershteyn
  • LIPID VESICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20160038415
    Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
    Type: Application
    Filed: June 17, 2015
    Publication date: February 11, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Jaehyun Moon