Patents by Inventor Darrell J. Koza

Darrell J. Koza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries
    Publication number: 20130029943
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Application
    Filed: December 6, 2011
    Publication date: January 31, 2013
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20120283201
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 8, 2012
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhalie, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-N-substituted phenyl tetracycline compounds
    Patent number: 8293931
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: October 23, 2012
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza
  • 7, 8 and 9-substituted tetracycline compounds
    Patent number: 8252777
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: August 28, 2012
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • 7-phenyl-substituted tetracycline compounds
    Patent number: 8168810
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: May 1, 2012
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 8106225
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: January 31, 2012
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 9-substituted minocycline compounds
    Patent number: 8048867
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: November 1, 2011
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • 7-N-Substituted Phenyl Tetracycline Compounds
    Publication number: 20110257421
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Darrell J. Koza
  • 7-N-substituted phenyl tetracycline compounds
    Patent number: 8012951
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: September 6, 2011
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza
  • 7,8 And 9-Substituted Tetracycline Compounds
    Publication number: 20110118215
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • 7, 8 and 9-substituted tetracycline compounds
    Patent number: 7875649
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: January 25, 2011
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • 7, 8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20100160265
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: March 9, 2010
    Publication date: June 24, 2010
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 7696187
    Abstract: The present invention relates to 9-substituted tetracycline derivatives as well as compositions and use thereof.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: April 13, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 7,8 and 9-substituted tetracycline compounds
    Patent number: 7696188
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: April 13, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • 7-N-Substituted Phenyl Tetracycline Compounds
    Publication number: 20100004211
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: January 21, 2009
    Publication date: January 7, 2010
    Inventors: Mark L. Nelson, Darrell J. Koza
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20090325908
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 31, 2009
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-substituted tetracycline compounds
    Patent number: 7595309
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 29, 2009
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Beena Bhatia, David Messersmith, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Darrell J. Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul K. Verma, Tadeusz Warchol, Upul Bandarage
  • 7-phenyl-substituted tetracycline compounds
    Patent number: 7521437
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: April 21, 2009
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 7,8 And 9-substituted tetracycline compounds
    Publication number: 20080167273
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: March 4, 2008
    Publication date: July 10, 2008
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • 7, 8 and 9-substituted tetracycline compounds
    Patent number: 7361674
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: April 22, 2008
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie