Patents by Inventor Darrell J. Koza

Darrell J. Koza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7, 8 and 9-substituted tetracycline compounds
    Patent number: 7094806
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: August 22, 2006
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 7067681
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: June 27, 2006
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 7-N-substituted phenyl tetracycline compounds
    Publication number: 20040224927
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: April 7, 2004
    Publication date: November 11, 2004
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Publication number: 20040033996
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Application
    Filed: July 9, 2003
    Publication date: February 19, 2004
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 6617318
    Abstract: The present invention relates to 7-phenyl substituted tetracycline derivatives and compositions thereof.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: September 9, 2003
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza