Abstract: Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Abstract: An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Abstract: Disclosed herein are methods of producing a scaffold by producing a biopolymer scaffold composition by pneumatospinning a polymer solution comprising polymer fibers onto a collector; feeding the polymer fiber solution comprising the polymer fiber into an air brush; applying a gas pressure around the polymer fiber solution comprising the polymer fiber in the airbrush; ejecting the polymer fiber from the air brush onto the collector; crosslinking the polymer fibers; and seeding a plurality of cells to the polymer scaffold composition.

Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

Abstract: An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A system and method is used to monitor, control, and/or provide feedback relative to one or more factors related to a patient's body, such as a shoulder, pursuant to a treatment process. The system monitors, controls, and/or provides feedback relative to shoulder factors including shoulder motion, shoulder muscle contraction, and external pressure on the shoulder.

Abstract: Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Abstract: Provided herein are compositions comprising collagen, dialdehyde starch, and at least one population of cells. Also, provided herein are methods of bioprinting and methods of producing cell-laden, three-dimensional scaffolds, comprising the compositions described herein.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Abstract: Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.

Abstract: Provided are an apparatus and method for injection of a fluid into a substrate. In some embodiments, an apparatus or method described herein delivers cells to a tissue scaffold, graft, or site of tissue injury to facilitate the repair of a tissue defect.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.

Abstract: Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Abstract: Disclosed herein are methods of printing a bio-ink on a substrate. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.

Abstract: A joint balancing insert with sensors and an actuated mechanism is disclosed. The joint balancing insert is used to balance a joint during arthroplasty surgery, as the sensors provide force, position and angular data relating to the movement of the joint, while the actuated mechanism allows for highly accurate and dynamic adjustments of the joint based on the data from the sensors. Various configurations of actuated mechanisms and sensors may be implemented in the insert to provide for manual or real time control of the insert, and customized interfaces are provided for visualized feedback of adjustments. Sensor data may also be collected and compared with expected or preferred data sets to provide adjustment recommendations and achieve better outcomes based on historical data.