Abstract: Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.

Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

Abstract: A joint balancing insert with an actuated mechanism is for balancing a joint during a joint surgery is disclosed. The joint balancing insert includes a first plate, a second plate and an actuator there between. The second plate includes an integrated mounting portion for mounting a cutting block used to guide surgical cuts of the joint during the joint surgery. Various configurations of the integrated mounting portion may be implemented in the insert to provide for mounting various types of cutting blocks, such as cutting blocks for tibial cuts, femoral cuts, and distal femoral cuts.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Processes are provided for preparing molecular sieves of framework structure MEI, TON, MRE, MWW, MFS, MOR, FAU, EMT, or MSE. The process involves preparing a synthesis mixture for the molecular sieve wherein the synthesis mixture includes a morphology modifier L selected from the group consisting of cationic surfactants having a quaternary ammonium group comprising at least one hydrocarbyl group having at least 12 carbon atoms, nonionic surfactants, anionic surfactants, sugars and combinations thereof.

Abstract: Processes are provided for preparing molecular sieves. The process involves preparing a synthesis mixture for the molecular sieve wherein the synthesis mixture includes a morphology modifier L selected from the group consisting of nonionic surfactants, anionic surfactants, sugars and combinations thereof.

Abstract: An aspiration system to control vacuum pressure in an ultrasonic surgical handpiece to result in improved control responsiveness during aspiration. The system comprises a console including a vacuum pump. The system includes a cassette comprising a joint that divides a vacuum path into at least two flow paths. A first joint port couples to a first flow path. A second flow path is coupled to a second joint port, a third flow path is coupled to a third joint port, and a fourth flow path is coupled to a port on a surgical waste receiver. A first sensor senses pressure in the fourth flow path and provides a waste receiver pressure signal. A second sensor senses pressure in the third flow path and provides a tip pressure signal. The controller controls a position of a first vent valve and a second vent valve based on the waste receiver pressure signal and the tip pressure signal, respectively.

Abstract: A joint balancing insert with an actuated mechanism is for balancing a joint during a joint surgery is disclosed. The joint balancing insert includes a first plate, a second plate and an actuator there between. The second plate includes an integrated mounting portion for mounting a cutting block used to guide surgical cuts of the joint during the joint surgery. Various configurations of the integrated mounting portion may be implemented in the insert to provide for mounting various types of cutting blocks, such as cutting blocks for tibial cuts, femoral cuts, and distal femoral cuts.

Abstract: A voluntary closing and locking prosthetic terminal device (1) having complex internal mechanisms configured into interchangeable cartridges (10) that provide end users with the capability of servicing the prosthetic on their own.

Abstract: Processes are provided for preparing molecular sieves for use as catalysts. The process involves preparing a synthesis mixture for the molecular sieve wherein the synthesis mixture includes a morphology modifier which may be selected from cationic surfactants having a single quaternary ammonium group comprising at least one hydrocarbyl group having at least 12 carbon atoms, nonionic surfactants, anionic surfactants, sugars, and combinations thereof.

Abstract: A system and method is used to monitor, control, and/or provide feedback relative to one or more factors related to a patient's body, such as a shoulder, pursuant to a treatment process. The system monitors, controls, and/or provides feedback relative to shoulder factors including shoulder motion, shoulder muscle contraction, and external pressure on the shoulder.

Abstract: An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Abstract: An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Abstract: A system and method is used to monitor, control, and/or provide feedback relative to one or more factors related to a patient's body, such as a shoulder, pursuant to a treatment process. The system monitors, controls, and/or provides feedback relative to shoulder factors including shoulder motion, shoulder muscle contraction, and external pressure on the shoulder.

Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Abstract: Methods and corresponding catalysts are provided for transalkylation of 1-ring (C9+) aromatic compounds, such as transalkylation to form para-xylene and/or other xylenes. Suitable catalysts include molecular sieves having a 3-D 12-member ring framework structure, molecular sieves having a 1-D 12-member ring framework structure, acidic microporous materials with a pore channel size of at least 6.0 Angstroms, and/or molecular sieves having a MWW framework structure. The methods include performing transalkylation where at least a portion of the feed to the transalkylation process is in the liquid phase. Optionally, the transalkylation conditions can correspond to conditions where a continuous liquid phase is present within the reaction environment. Some embodiments include liquid phase transalkylation processes for naphthalene-containing feedstock streams.

Abstract: Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Abstract: Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Abstract: Methods and systems include determining travel information from vehicles. In one embodiment, a system monitors traffic on a roadway in real-time. The system includes a plurality of reader devices. The reader devices are capable of asynchronously capturing a unique network identifier of a device in a vehicle when the device is disposed in reader range of the reader devices. The reader device time stamps each captured unique network identifier. The time stamped unique network identifier is forwarded to a host module. The host module receives the time stamped unique network identifier. In addition, the host module determines travel information from the time stamped unique network identifier by comparing the time stamped unique network identifier for a particular vehicle to other time stamped unique network identifiers captured for the particular vehicle.