Patents by Inventor Datong Tang

Datong Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,6-bicyclolides
    Patent number: 7419962
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 2, 2008
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yat Sun Or, Datong Tang, Ying Sun, Yonghua Gai, Guoyou Xu, Zhe Wang
  • QUINOXALINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
    Publication number: 20080152622
    Abstract: The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 26, 2008
    Inventors: Suanne Nakajima, Zhenwei Miao, Ying Sun, Datong Tang, Guoyou Xu, Brian Porter, Yat Sun Or, Zhe Wang
  • Polymorphic forms of 6-11 bicyclic ketolide derivatives
    Patent number: 7384921
    Abstract: The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: June 10, 2008
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Guoyou Xu, Yonghua Gai, Zhe Wang, Yat Sun Or, Hui-Yin Li
  • Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
    Patent number: 7368452
    Abstract: The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: May 6, 2008
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Suanne Nakajima, Zhenwei Miao, Ying Sun, Datong Tang, Gouyou Xu, Brian Porter, Yat Sun Or, Zhe Wang
  • MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS
    Publication number: 20080008681
    Abstract: The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: June 26, 2007
    Publication date: January 10, 2008
    Inventors: Deqiang Niu, Dong Liu, Joel Moore, Guoyou Xu, Ying Sun, Yonghua Gai, Datong Tang, Yat Sun Or, Zhe Wang
  • Quinoxalinyl Macrocyclic Hepatitis C Virus Serine Protease Inhibitors
    Publication number: 20070299078
    Abstract: The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: June 26, 2007
    Publication date: December 27, 2007
    Inventors: Deqiang Niu, Dong Liu, Joel Moore, Guoyou Xu, Ying Sun, Yonghua Gai, Datong Tang, Yat Or, Zhe Wang
  • Tetracyclic bicyclolides
    Patent number: 7312201
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: December 25, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Yat Sun Or, Zhe Wang
  • 11,12-lactone bicyclolides
    Patent number: 7291602
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: November 6, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Zhigang Chen, Yat Sun Or, Zhe Wang
  • Tri-peptide hepatitis C serine protease inhibitors
    Patent number: 7273851
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: September 25, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Zhe Wang, Yat S. Or
  • Tri-peptide hepatitis C serine protease inhibitors
    Publication number: 20070161575
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: November 20, 2006
    Publication date: July 12, 2007
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Zhenwei Miao, Ying Sun, Suanne Nakajima, Datong Tang, Zhe Wang, Yat Or
  • 3,6-Bicyclolides
    Patent number: 7229972
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: June 12, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yat Sun Or, Datong Tang, Yonghua Gai, Ying Sun, Guoyou Xu, Zhe Wang
  • Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
    Publication number: 20070060510
    Abstract: The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: July 18, 2006
    Publication date: March 15, 2007
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Suanne Nakajima, Zhenwei Miao, Ying Sun, Datong Tang, Guoyou Xu, Brian Porter, Yat Or, Zhe Wang
  • Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
    Patent number: 7176208
    Abstract: The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: February 13, 2007
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Suanne Nakajima, Zhenwei Miao, Ying Sun, Datong Tang, Guoyou Xu, Brian Porter, Yat Sun Or, Zhe Wang
  • Spirocyclic bicyclolides
    Publication number: 20060252713
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: May 3, 2006
    Publication date: November 9, 2006
    Inventors: Yonghua Gai, Datong Tang, Ying Sun, Zhigang Chen, Yat Or, Zhe Wang
  • Processes for the preparation of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
    Publication number: 20060247440
    Abstract: The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1.
    Type: Application
    Filed: August 17, 2005
    Publication date: November 2, 2006
    Inventors: Datong Tang, Yao-Ling Qiu, Heejin Kim, Yat Or, Zhe Wang
  • 11,12-Lactone bicyclolides
    Publication number: 20060148731
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Zhigang Chen, Yat Or, Zhe Wang
  • Tetracyclic bicyclolides
    Publication number: 20060142215
    Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Inventors: Datong Tang, Yonghua Gai, Ying Sun, Yat Or, Zhe Wang
  • 3,6-bicyclolides
    Publication number: 20060142214
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: June 29, 2006
    Inventors: Yat Or, Datong Tang, Ying Sun, Yonghua Gai, Guoyou Xu, Zhe Wang
  • 3,6-Bicyclolides
    Publication number: 20060122128
    Abstract: The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
    Type: Application
    Filed: December 7, 2004
    Publication date: June 8, 2006
    Inventors: Yat Or, Datong Tang, Yonghua Gai, Ying Sun, Guoyou Xu, Zhe Wang
  • Processes for the preparation of 6-11 bicyclic erythromycin derivatives
    Publication number: 20060058248
    Abstract: The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives.
    Type: Application
    Filed: October 25, 2005
    Publication date: March 16, 2006
    Inventors: Guoyou Xu, Datong Tang, Yonghua Gai, Heejin Kim, Guoqiang Wang, Ly Phan, Yat Or, Zhe Wang