Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Methods are provided for generating training data in a form of a plurality of frames of facial animation, each of the plurality of frames represented as a three-dimensional (3D) mesh comprising a plurality of vertices. The training data is usable to train an actor-specific actor-to-mesh conversion model which, when trained, receives a performance of the actor captured by a head-mounted camera (HMC) set-up and infers a corresponding actor-specific 3D mesh of the performance of the actor. The methods may involve performing a blendshape optimization to obtain a blendshape-optimized 3D mesh and performing a mesh-deformation refinement on the blendshape-optimized 3D mesh to obtain a mesh-deformation-optimized 3D mesh. The training data may be generated on the basis of the mesh-deformation-optimized 3D mesh.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Movement of an autonomously motile device may be controlled by a user device. The user device may display image data captured by a camera of the autonomously motile device; a user may provide input, such as a touch gesture on a display screen, indicating a command for the autonomously motile device to move to a location indicated by the input. The autonomously motile device determines a coordinate of the input and a time of the touch input; the autonomously motile device then determines a direction and distance of a corresponding movement.

Abstract: A method of cooling a vane of a turbine is provided. The turbine includes an airfoil, an outer shroud disposed at an outer radial end of the airfoil and an inner shroud, the airfoil including a plurality of air channels extending along the radial direction of the turbine, the air channels comprising a first air channel and a second air channel. A cooling air is caused to flow inside the first air channel to cool the first air channel, then cool one of the outer shroud and the inner shroud. A cooling air is caused to flow inside the second air channel to cool the second air channel, then cool the other one of the outer shroud and the inner shroud.

Abstract: A method and apparatus for processing documents is provided. The documents may be conveyed to a feeder for feeding documents to a scanner. The scanner scans each document to obtain image data and then discharges the document to one or more output or sort locations. The system may include a skew reduction assembly for reducing skew in the documents as the documents are fed to the scanner. The system may also include elements for improving image quality and reducing document damage while the document is scanned. The system may further include features for improving the stacking of the discharged documents.

Abstract: Aspects of the present disclosure relate to fail open or fail close actuator assemblies and related methods for valve systems. In one implementation, an actuator assembly for valves includes an outer housing that includes an inner surface at least partially defining an internal volume. The actuator assembly includes one or more first fluid openings formed in the outer housing, one or more second fluid openings formed in the outer housing, and one or more ambient openings formed in the outer housing. The actuator assembly includes a valve stem disposed at least partially in the internal volume, and a first piston disposed in the internal volume and coupled to the valve stem. The actuator assembly includes a second piston disposed in the internal volume and disposed about the valve stem.

Abstract: A computer-based system for facilitating the execution of law enforcement duties is disclosed. More particularly, according to one aspect of the invention, an electronic system is configured to facilitate the performance of law enforcement duties by quasi-instantaneously providing actionable intelligence to its users, such as front-line law enforcement officers, in response to a real-time query. According to another aspect of the invention, a system implements a set of automated status classifications for subjects with suspected or confirmed involvement in criminal activities. The status classifications specifically and concisely establish the subject's involvement in criminal activities. According to yet another aspect of the invention, a system executes a streamlined electronic process for handling and processing seized items so as to ensure that criminal assets are efficiently and effectively seized, and that asset forfeiture actions are effectively initiated against the seized items.

Abstract: Systems for maintaining light sources for semiconductor photolithography in which a module making up part of the light source is evaluated at various pulse counts to produce a binary prediction as to whether the module is sufficiently likely to operate without failure in an ensuing sequence of pulses. The binary prediction may be made by a machine learning model trained on metrics extracted from measurements taken on deinstalled modules. A group of models, each trained differently, can be made available according to a selection made by the user or according to the maintenance objectives of the user.

Abstract: Point-in-Time data access authorization is realized by a data access broker and data access security manager that provide for a data owner/authorizer to provide access consent at the point in time at which a specific data access request is made, without the need for the data owner to share their service-specific access credentials with the third-party entity/data requester. As a result, the data owner has control over the authorization of each data access request and has knowledge as to when the third-party entity is accessing the data. Further, by not having to share access credentials with the third-party entity/data requester security issues related to exposure and/or misuse of the access credentials are avoided.

Abstract: Disclosed is a method for preparing a nanoparticle composition. The method includes forming a nanoparticle aerosol in a low pressure reactor, wherein the aerosol comprises MX-functional nanoparticles entrained in a gas, where M is an independently selected Group IV element and X is a functional group independently selected from H and a halogen atom. The method further includes collecting the MX-functional nanoparticles of the aerosol in a capture fluid, where the capture fluid is in fluid communication with the low pressure reactor. The capture fluid includes a polar aprotic fluid immiscible with water and having a viscosity of from 5 to 200 centipoise at 25° C. The capture fluid further includes a functionalization compound miscible with the polar aprotic fluid, the functionalization compound comprising a functional group Y reactive with the functional group X of the MX-functional nanoparticles.

Abstract: An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk.

Abstract: A system is provided for processing documents. In particular, the system is incorporates a feeder for feeding documents to a device for further processing of the documents. For instance, the system finds particular application in the field of document imaging in which a variety of documents of varying sizes and orientation are to be fed to an imaging system, such as a document scanner. The system may provide an input mechanism for easily identifying a characteristic of one of the documents and the system may include features for handling packets of documents.

Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.

Abstract: A fluid filtration assembly (FFA) includes a housing having a thickness defined between an internal surface and an external surface, the housing receiving a filter and defining an outer annular flow passage between an outer surface of the filter and the internal surface of the housing; an inlet pipe communicates with the FFA and injects a fluid into the housing to impart a centrifugal force; an outlet pipe communicates with the FFA and discharges the fluid from the housing; and a collection area disposed towards an end of the outer annular flow passage collects particulate matter from the fluid; wherein a width of the outer annular flow passage increases towards the collection area.

Abstract: Described herein are compositions and methods that utilize complementary polymerization reactions to simultaneously generate one or more polymeric materials, including crosslinked polymer matrices, tethered inter-penetrating network, heterogenous polymer blends, or homogeneous polymer blends. The provided compositions and methods utilize the combination of an energy demanding step-growth reaction with a highly exothermic reaction to drive the energy demanding reaction by chemical heating and avoid issues associated with thermal runaway, such as solution boiling or unwanted biproducts.

Abstract: Systems and methods for managing network resources are disclosed. One method can comprise receiving first information relating to network traffic parameters and receiving second information relating to one or more contextual events having an effect on the network traffic parameters. The first information and the second information and be correlated. And one or more network resources can be allocated based on the correlation of the first information and the second information.

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

Abstract: A method includes decomposing, for each of a plurality of orthogonal slices, a set of PRF baseline images for the orthogonal slice into a set of baseline image features for the orthogonal slice; acquiring, using a magnetic imaging resonance (MRI) scanner of a MRI system based on a RF excitation pulse sequence for each of the plurality of orthogonal slices, a combined multi-encoded PRF treatment image; subtracting a weighted sum of the sets of baseline image features from the combined multi-encoded PRF treatment image to obtain a combined treatment-specific temperature information of the imaging region that provides multi-orthogonal slice temperature information associated with or resulting from treatment or thermal ablation of the imaging region of the patient after subtraction or removal of the baseline image features; and processing the combined treatment-specific temperature information to obtain slice-specific treatment-specific temperature information for each of the plurality of orthogonal slices.