Patents by Inventor David A. Butler

David A. Butler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipids and compositions for the delivery of therapeutics
    Patent number: 9220683
    Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures: (Formula (I) or (XXXV)).
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: December 29, 2015
    Assignee: Tekmira Pharmaceuticals Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, David Butler, Jayaprakash K. Narayanannair, Muthusamy Jayaraman, Laxmab Eltepu
  • GAS TURBINE ROTOR BLADE AND GAS TURBINE ROTOR
    Publication number: 20150361814
    Abstract: A gas turbine rotor and blade include a root portion, a platform and airfoil portion arranged along a span direction of the rotor blade, the platform located between the root and airfoil portion. The platform has an upstream and downstream side, side faces which extend from upstream to downstream side, an axial groove in each side face extends perpendicular to the span direction with a minor component of extension in span direction. A radial groove in each side face extends towards the axial groove with a component of extension in span direction and a component of extension perpendicular to the span direction. The radial groove has a first end that shows away from the axial groove and a second end that shows towards the axial groove. The second end is located a distance from the axial groove forming a groove free section between the second end and axial groove.
    Type: Application
    Filed: January 14, 2014
    Publication date: December 17, 2015
    Applicant: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Richard Bluck, David Butler, Jonathan Mugglestone, David Overton
  • TURBOMACHINE ROTOR BLADE, TURBOMACHINE ROTOR DISC, TURBOMACHINE ROTOR, AND GAS TURBINE ENGINE WITH DIFFERENT ROOT AND SLOT CONTACT FACE ANGLES
    Publication number: 20150361803
    Abstract: A turbomachine rotor blade has a firtree shaped root, to be secured in a rotor disc rotatable around a rotor axis. In a plane perpendicular to the rotor axis, the root has a first, second, and third root lobe with a first, second, and third root contact face. Each of the first, second, and third root contact face is angled relative to a radial root bottom axis with a first, second, and third root angle, respectively. The first root angle is smaller than the second and the second root angle is substantially equal to the third. A turbomachine rotor disc has a firtree shaped slot having a first, second, and third slot angle, the first slot angle being smaller than the second and the second slot angle being substantially equal to the third. A gas turbine engine has the turbomachine rotor herein.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 17, 2015
    Applicant: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Richard Bluck, David Butler, David Overton
  • Drive Assembly, Drive Component and Drug Delivery Device
    Publication number: 20150359971
    Abstract: A drive assembly (70) for a drug delivery device (1) comprises a rotation member (21) being configured to be rotated in a first direction (44) during setting of a dose of a drug and to be rotated in a second direction (47) during delivery of the dose, a drive component (20) being configured to follow rotational movement of the rotation member (21) in the second direction (47) during delivery of the dose and a stop member (26) being configured to prevent rotational movement of the drive component (20) in the first direction (44). The drive component (20) comprises a first drive part (71) and a second drive part (72), coupled to each other such that relative rotational movement of the first and second drive parts (71, 72) is prevented and relative axial movement is permitted.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 17, 2015
    Inventors: Christopher James Smith, Stephen David Butler, Mark Philip Horlock
  • AIRFOIL ARRANGEMENT WITH PTAL BOND COATING AND THERMAL BARRIER COATING, AND CORRESPONDING MANUFACTURING METHOD
    Publication number: 20150322804
    Abstract: An airfoil with a coated surface section which having a platinum aluminide and a TBC coating is provided herein. Furthermore, an airfoil arrangement for a gas turbine including an airfoil, an inner shroud, and an outer shroud, wherein the airfoil is arranged between the inner shroud and the outer shroud, wherein the airfoil comprises a coated surface section which is coated with a platinum-aluminide coating and a thermal barrier coating and which represents at least a part of the total surface of the airfoil, wherein the thermal barrier coating of the coated surface section is spaced from the inner shroud and/or the outer shroud with a distance (x) and wherein the distance (x) is between 5% and 25% of a total length of the airfoil between the inner shroud and the outer shroud is provided herein.
    Type: Application
    Filed: March 26, 2013
    Publication date: November 12, 2015
    Applicant: SIEMENS AKTIENGESELLSCHAFT
    Inventors: David Butler, Paul Jenkinson, Paul Padley, Paul Mathew Walker
  • Video management system for interactive online instruction
    Patent number: 9165473
    Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: October 20, 2015
    Assignee: ArtistWorks, Inc.
    Inventor: David A. Butler
  • NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
    Publication number: 20150265708
    Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.
    Type: Application
    Filed: February 24, 2015
    Publication date: September 24, 2015
    Applicant: TEKMIRA PHARMACEUTICALS CORPORATION
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Jayaprakash K. Narayanannair, Martin Maier, Laxman Eltepu
  • DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE
    Publication number: 20150238699
    Abstract: The present invention concerns a drive mechanism for a drug delivery device comprising a housing having a longitudinal axis, a first feedback element which is movable along the longitudinal axis relative to the housing and a second feedback element, wherein the first feedback element and the second feedback element are adapted to interact with each other thereby providing at least one of tactile and audible feedback during at least one of a dose setting and dose dispensing operation of the drive mechanism. Moreover a drug delivery device incorporating such a drive mechanism is disclosed.
    Type: Application
    Filed: September 9, 2013
    Publication date: August 27, 2015
    Inventors: Stephen David Butler, Mark Philip Horlock
  • Apparatus and method for manufacturing an electronic package
    Patent number: 9111189
    Abstract: An apparatus to package an electronic device. The apparatus includes a composite plastic package that is durable to environmental conditions. In particular, a mold process to produce a plastic composite material package and support an electronic component inserted therein. At least one injection nozzle supplies a specified level of plastic composite material into the mold to produce a substantially hermetically sealed package. A multi-patch antenna provides increased receiver sensitivity. An inductive battery power option provides a user flexibility to charge a tracking device and communicate near-field signals and energy with a tracking monitoring station.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 18, 2015
    Assignee: Location Based Technologies, Inc.
    Inventors: Joseph F. Scalisi, David M. Morse, David Butler
  • TURBINE VANE ARRANGEMENT
    Publication number: 20150226073
    Abstract: A guide vane arrangement of a gas turbine and a method of manufacturing a guide vane arrangement of a gas turbine are provided herein. The guide vane arrangement includes a first guide vane device including a first radially inner platform and a first number of first airfoils, and a second guide vane device including a second radially inner platform and a second number of second airfoils. The first guide vane device and the second guide vane device are arranged along a circumferential direction of the turbine, wherein the first number of the first airfoils differs to the second number of the second airfoils. The first guide vane device is designed with a higher heat resistance than the second guide vane device.
    Type: Application
    Filed: August 22, 2013
    Publication date: August 13, 2015
    Applicant: Siemens Aktiengesellschaft
    Inventors: Stephen Batt, Richard Bluck, David Butler
  • CHIRAL CONTROL
    Publication number: 20150211006
    Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 30, 2015
    Inventors: David Butler, Naoki Iwamoto, Meena Meena, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
  • CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION
    Publication number: 20150203847
    Abstract: The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Application
    Filed: December 31, 2014
    Publication date: July 23, 2015
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Takeshi YAMADA, David BUTLER, Narayanannair K. JAYAPRAKASH, Muthusamy JAYARAMAN, Shigeo MATSUDA, Rajendra K. PANDEY, Chang Geng PENG
  • LIPID COMPOSITIONS
    Publication number: 20150190515
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Application
    Filed: October 7, 2014
    Publication date: July 9, 2015
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • TOOL FOR REMOVING CEDAR ROOFING MATERIAL
    Publication number: 20150176284
    Abstract: There is provided a tool for removing cedar roofing material. The tool has a handle with a first end and a second end which is spaced-apart from the first end. The second end of the handle is inclined. The tool includes a blade having a base portion connected to the second end of the handle. The blade has a proximal end which is adjacent to the base portion of the blade. The blade has a distal end which is spaced-apart from the base portion of the blade. The blade is arcuate-shaped between its proximal end and its distal end. The base portion is angled relative to the proximal end of the blade.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 25, 2015
    Inventor: David Butler
  • Drive Mechanism for a Drug Delivery Device and Drug Delivery Device
    Publication number: 20150165130
    Abstract: The drive mechanism for a drug delivery device comprises a piston rod, which is displaced in a distal direction for a delivery of a dose and in a proximal direction for a reset, and a rotatable drive member, which is threadedly engaged with the piston rod and rotates during the delivery of the dose. A biasing member is provided, which is loaded by the rotation of the drive member during the delivery of the dose and tends to rotate the piston rod with respect to the drive member in such a way that the piston rod is screwed into the drive member and is thereby advanced in the proximal direction. The drug delivery device is provided with such a drive mechanism.
    Type: Application
    Filed: May 28, 2013
    Publication date: June 18, 2015
    Inventors: Stephen David Butler, Mark Philip Horlock
  • Bearing for a Piston Rod Body for a Drug Delivery Device, a Piston Rod Arrangement and a Piston Rod Body
    Publication number: 20150133874
    Abstract: The present disclosure concerns a bearing for a piston rod body for a drug delivery device. The bearing has an axis and comprises a first and a second surface which are spaced apart in the direction of the axis and a third surface, wherein the third surface connects the first and the second surface, wherein an opening is provided in each of the first and the third surface, and wherein the opening in the first surface is connected to the opening in the third surface. Further, the present disclosure concerns a piston rod body and a piston rod arrangement comprising said bearing and the piston rod body.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 14, 2015
    Inventors: Stephen David Butler, Mark Philip Horlock
  • PISTON ROD FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE COMPRISING A PISTON ROD
    Publication number: 20150133872
    Abstract: A piston rod for a drug delivery device comprises a main body and an engagement means for engaging the piston rod with a part of the drug delivery device. The engagement means are retractable relatively the main body for enabling a disengagement of the engagement means from the part of the drug delivery device.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 14, 2015
    Applicant: Sanofi-Aventis Deutschland GMBH
    Inventors: Christopher James Smith, Stephen David Butler, Mark Phillip Horlock
  • Lipids and compositions for the delivery of therapeutics
    Patent number: 8999351
    Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: April 7, 2015
    Assignee: Tekmira Pharmaceuticals Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Jayaprakash K. Narayanannair, Martin Maier, Laxman Eltepu
  • DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE
    Publication number: 20150088079
    Abstract: The drive mechanism for a drug delivery device comprises a piston rod, which is displaced in a distal direction for a delivery of a dose and in a proximal direction for a reset, and a resilient member, which acts on the piston rod during a reset and tends to restrict the movement of the piston rod in the proximal direction. The resilient member may be a biasing member provided for an automatic reset, a compression spring entering the piston rod or a torsion spring provided to generate a rotation. The drug delivery device is provided with such a drive mechanism.
    Type: Application
    Filed: May 28, 2013
    Publication date: March 26, 2015
    Inventors: Stephen David Butler, Mark Philip Horlock
  • Chemical modifications of monomers and oligonucleotides with cycloaddition
    Patent number: 8962580
    Abstract: The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: February 24, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Takeshi Yamada, David Butler, Narayanannair K. Jayaprakash, Muthusamy Jayaraman, Shigeo Matsuda, Rajendra K. Pandey, Chang Geng Peng