Abstract: A drive mechanism for a drug delivery device is presented that can be switched between a normal operation mode and a reset mode. A piston rod is displaced in a distal direction to deliver a dose in a normal operation mode and is displaced in the proximal direction in a reset mode. The drive mechanism also has a drive member that is rotationally moveable with respect to the housing, wherein in the normal operation mode, the drive member is coupled with the piston rod so that rotational movement of the drive member in the rotation direction with respect to the housing is converted into movement of the piston rod in the distal direction with respect to the housing, and wherein, in the reset mode, the piston rod is decoupled from the drive member.

Abstract: A piston rod for a drug delivery device comprises a main body and an engagement means for engaging the piston rod with a part of the drug delivery device. The engagement means are retractable relatively the main body for enabling a disengagement of the engagement means from the part of the drug delivery device.

Abstract: A drive assembly (70) for a drug delivery device (1) comprises a rotation member (21) being configured to be rotated in a first direction (44) during setting of a dose of a drug and to be rotated in a second direction (47) during delivery of the dose, a drive component (20) being configured to follow rotational movement of the rotation member (21) in the second direction (47) during delivery of the dose and a stop member (26) being configured to prevent rotational movement of the drive component (20) in the first direction (44). The drive component (20) comprises a first drive part (71) and a second drive part (72), coupled to each other such that relative rotational movement of the first and second drive parts (71, 72) is prevented and relative axial movement is permitted.

Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Abstract: A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.

Abstract: A drive assembly (70) for a drug delivery device (1) comprises a rotation member (21) being configured to be rotated in a first direction (44) during setting of a dose of a drug and to be rotated in a second direction (47) during delivery of the dose, a drive component (20) being configured to follow rotational movement of the rotation member (21) in the second direction (47) during delivery of the dose and a stop member (26) being configured to prevent rotational movement of the drive component (20) in the first direction (44). The drive component (20) comprises a first drive part (71) and a second drive part (72), coupled to each other such that relative rotational movement of the first and second drive parts (71, 72) is prevented and relative axial movement is permitted.

Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

Abstract: A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation

Abstract: A prescription dispensing system having a dispensing station for holding an inventory of prescription medications, a secure internet connection to the dispensing station for access by a potential prescription medication recipient, by healthcare personnel in a physician office and by pharmacy personnel at the pharmacy distribution center in a remote location, at least two webcams for visual and auditory communication between the location of the dispensing station and the pharmacy personnel via the internet to allow identification of the correct medication, identification and communication with the correct potential prescription medication recipient, and visual validation and recording of all documentation from the physician's office or potential prescription medication recipient, and a biometric reader disposed at the dispensing station for identifying a potential prescription medication recipient.

Abstract: In some embodiments, a system includes a software program capable of performing an aliasing function on the personally identifiable information (“PII”) of a subject. The software can associate the alias with the PII, and output the alias rather than the PII.

Abstract: An information handling system is returned to its original manufacture state with a tool stored on a detachable memory device that retrieves image restore information from non-volatile memory of the information handling system, cleanses information stored on the non-volatile memory and then returns the image restore information to the non-volatile memory. By executing an image restore tool that applies the image restore information, the original manufacture image is re-built in the non-volatile memory after the cleansing so that any personal information stored on the non-volatile memory by a previous user is erased.

Abstract: In some embodiments, a non-transitory processor-readable medium stores code representing instructions for execution by a computer processor. The instructions cause the processor to produce a list of subjects by identifying a plurality of subjects based on information associated with an analyst-selected topic. The list of subjects is expanded to include subjects that have a relationship with at least one subject from the first list of subjects. Subjects are removed from the list based on either a filter or a scoring threshold. The expanding and removing subjects is iterated until the list of subjects is substantially stable to produce a final list of subjects. A graphical network is defined based on the final list of subjects and a signal is sent representing the graphical network (e.g., to a computer monitor for display).

Abstract: The drive mechanism comprises a drive member inside a housing, a rotation member and a dose member. The drive member is rotatable with respect to the housing. The rotation member is also rotatable and unidirectionally rotationally engaged with the drive member. The dose member is able to move along a set/deliver path between a first axial position and a second axial position in either direction or to move along a cancel path from the second axial position to the first axial position. An engagement of the dose member with the rotation member causes the rotation member to rotate when the dose member is moved along the set/deliver path. The drive member is not rotated when the dose member is moved along the cancel path. A button in/out spline can be provided for the set/deliver path and a cancel spline for the cancel path.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

Abstract: A drug delivery device (1) is disclosed which comprises a housing (2) having a longitudinal axis, a piston rod (3), at least one resilient guide member (4) for guiding the piston rod (3) in a drug dispense operation and a cartridge holder (5) for receiving a cartridge (6), wherein the cartridge holder (5) is detachable from the housing (2). Furthermore the drug delivery device (1) is configured such that the resilient guide member (4) is allowed to relax when the cartridge holder (5) is detached from the housing (2).

Abstract: The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

Abstract: An apparatus is provided that includes an optical noise generator and a noise combiner. The noise generator is configured to produce an optical signal having a noise channel. The noise combiner is configured to combine an optical data channel with the noise channel received at one or more add ports to produce an optical output signal. A controller is configured to operate the noise generator or the noise combiner to provide a variable bandwidth of added noise combined with the optical data channel.

Abstract: A system for interactive online instruction includes an instructional subscription website and video management system configured to process video recordings. The video recordings may include (i) student videos uploaded by a student and (ii) instructor videos providing feedback to said student videos. A method of interactive online instruction is also disclosed. The method includes the steps of providing prerecorded course materials on an instructional subscription website including video lessons accessible by subscribing students, and providing a video management system configured to process video recordings including (i) student videos submitted by a student and (ii) instructor videos providing feedback to said student videos.

Abstract: A deflector for guiding a cooling fluid to a blade device of a turbine is provided. The deflector includes a first opening region with a first opening shape and a second opening region with a second opening shape. The deflector is connectable to a first blade device and to a second blade device in such a way that the cooling fluid is streamable through the first opening region into the first blade device and the cooling fluid is streamable through the second opening region into the second blade device. The first opening shape differs from the second opening shape for achieving a predetermined first mass flow of the cooling fluid into the first blade device and a predetermined second mass flow of the cooling fluid into the second blade device at predetermined installation locations of the first blade device and the second blade device.