Abstract: An apparatus for aligning non-synchronous input data streams received in the apparatus, the apparatus comprising an analogue to digital converter arrangement for digitising the data streams into a plurality of sequences of samples; and a synchronisation processing arrangement for generating alignment pulses for each sequence of the plurality of sequences of samples, for arranging each sequence of samples with respect to the alignment pulses for the sequence and for synchronisation the delivery of said plurality of sequences of samples to a common processor with respect to the respective alignment pulses. The synchronisation processing arrangement may comprise a processing chain for each antenna feed of said plurality of antenna feeds and each processing chain may comprise an alignment pulse generator for generating an alignment pulse for the sequence of samples corresponding to the processing chain. The input data streams may be received by a plurality of antenna feeds.

Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

Abstract: A computer-implemented system and method for the processing and presentation of aviation information is disclosed. At plurality of flight information is received over a digital network and is stored in at least a database. The database includes aviation information. Upon receiving a user request, a server retrieves a result set from the database and transmits it to the requesting user. Subsequently, updates as to a flight identified in the request are transmitted at a selected rate, which may be modified automatically based on one flight characteristic, for subsequent display. In one form, the results may be presented to the user in the form of digital map having aircraft images.

Abstract: A computer-implemented system and method for the processing and presentation of flight tracking data from a number of sources, with at least one source include a user access restriction, is disclosed. Substantially real-time flight tracking data is received over a digital network from a number of different sources and is stored in at least a database. Various determined flight paths are stores for a single flight based upon the number of flight data sources contributing data regarding that flight. Upon receiving a query from a user, the user's access with respect to the available data providers in retrieved and the best flight for the selected flight which is determined only from data that the requested user is authorized to access is presented. In one form, the results may be presented to the user in the form of digital map having an aircraft image and historical flight path shown.

Abstract: A computer based system and method for distributing a global shaper rate implemented across multiple traffic processing devices. A controller distributes credits according to the demand (amount of traffic, or offered load) of each device, in such a way to achieve global targets, including the shaper rate, strict prioritization of traffic, WFQ weights and fairness between cloned channels, iteratively updated as changes occur in the quantity and makeup of the traffic across the devices.

Abstract: A computer-implemented system and method for the processing and presentation of aviation information is disclosed. At plurality of flight information is received over a digital network and is stored in at least a database. The database includes aviation information. Upon receiving a user request, a server retrieves a result set from the database and transmits it to the requesting user. Subsequently, updates as to a flight identified in the request are transmitted at a selected rate, which may be modified automatically based on one flight characteristic, for subsequent display. In one form, the results may be presented to the user in the form of digital map having aircraft images.

Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract: A computer-implemented system and method for the processing and presentation of aviation information is disclosed. At plurality of flight information is received over a digital network and is stored in at least a database. The database includes aviation information. Upon receiving a user request, a server retrieves a result set from the database and transmits it to the requesting user. Subsequently, updates as to a flight identified in the request are transmitted at a selected rate, which may be modified automatically based on one flight characteristic, for subsequent display. In one form, the results may be presented to the user in the form of digital map having aircraft images.

Abstract: Disclosed is an exemplary multiple hypothesis engine that provides situation assessment capabilities regarding cyber auto tactics techniques and procedures. Dynamic cyber adversarial operations are evaluated via a combination of techniques using a Bayesian multiple hypothesis tree, or graph, as a framework. A top-down probability propagation mechanism solves different aspects of the problem in a round-robin fashion. The top-down probability propagation mechanism comprises the Hypothesis Refinement Engine. A model-based abductive reasoner comprising The Hypothesis Validator is used to confirm or refute the refined hypothesis. A model-based learning engine comprising Behavior Model Trainer is used to incrementally augment the knowledge base of behavior models as new adversarial TTPs are discovered. These three techniques behave in a cooperative manner by operating upon the Bayesian multiple hypothesis tree framework.

Abstract: A computer-implemented system and method for the collection, filtering, and transmission of aviation information is disclosed. A plurality of flight information is received over a digital network at various remote locations, and the data is filtered prior to transmission to a central database for presentation and use. The database includes aviation information. The method of filtration is dynamically updated as to information concerning a specific flight based on one characteristic of the flight. As to aircraft being tracked, a determination is made as to which receiver should relay collected data, and that determination is periodically revised, such as to minimize transmission costs and maximize signal quality as aircraft positions change. Once the information is located in the central database, it is suitable for use in responding to user requests for flight tracking information is association with at least one identified flight.

Abstract: The present disclosure provides a system and a method for managing network traffic. The traffic management system has a quality of experience (QoE) measurement module configured to monitor a QoE metric in real-time. A control module is configured to periodically receive the QoE metric and determine a traffic management action based on the QoE metric. A traffic management module is configured to apply the traffic management action to the network traffic.

Abstract: A computer-implemented system and method for the processing and presentation of aviation information is disclosed. At plurality of flight information is received over a digital network and is stored in at least a database. The database includes aviation information. Upon receiving a user request, a server retrieves a result set from the database and transmits it to the requesting user. Subsequently, updates as to a flight identified in the request are transmitted at a selected rate, which may be modified automatically based on one flight characteristic, for subsequent display. In one form, the results may be presented to the user in the form of digital map having aircraft images.

Abstract: The invention relates to the production of compositions containing milk products for use as a nutritional supplement. More specifically, it relates to compositions containing whey growth factor extract, as well as their use in methods for reducing muscle inflammation in individuals undertaking resistance exercise training. According to one aspect of the invention, there is provided the use of a composition comprising whey growth factor extract, isolated from a milk product by cation exchange chromatography, to reduce exercise-induced muscle inflammation.

Abstract: A computer-implemented system and method for the processing and presentation of flight tracking data from a number of sources, with at least one source include a user access restriction, is disclosed. Substantially real-time flight tracking data is received over a digital network from a number of different sources and is stored in at least a database. Various determined flight paths are stores for a single flight based upon the number of flight data sources contributing data regarding that flight. Upon receiving a query from a user, the user's access with respect to the available data providers in retrieved and the best flight for the selected flight which is determined only from data that the requested user is authorized to access is presented. In one form, the results may be presented to the user in the form of digital map having an aircraft image and historical flight path shown.

Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.

Abstract: The invention relates to the production of compositions containing milk products for use as a nutritional supplement. More specifically, it relates to compositions containing whey growth factor extract, as well as methods for supplementing the nutritional needs of individuals undertaking resistance exercise training. According to one aspect of the invention, there is provided the use of a composition comprising whey growth factor extract, isolated from a milk product by cation exchange chromatography, to increase skeletal muscle strength.

Abstract: A three dimensional display apparatus includes a diffraction panel for displaying a computer generated hologram and a look-up table. The look-up table includes a plurality of phase entries corresponding to a plurality of image points within a three dimensional image replay volume of the computer generated hologram. The apparatus further includes one or more processors configured to notionally divide the computer generated hologram into one or more hogels and to calculate diffraction fringe information for at least one of the hogels based on a selection of the phase entries.

Abstract: There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided a peptide selected by such a method and its use in a pharmaceutical composition and a method to treat and/or prevent a disease. The present invention also relates to a composition which comprises the following myelin basic protein (MBP) peptides: MBP 30-44; MBP 83-99; MBP 131-145; and MBP 140-154. The composition may be used to treat a disease, in particular multiple sclerosis and/or optical neuritis and the invention also relates to such uses and methods.

Abstract: A computer-implemented system and method for the processing and optimization of flight plans is disclosed. Information regarding a plurality of previous flight plans is received over a digital network and is stored in at least a database. The database preferably includes aviation fuel price information, aircraft performance information, and aviation weather information as well. Upon receiving a request, a server generates at least an optimized portion of a flight plan. In one form, historical flight plan data of others is automatically used to aid in the determination of the optimized route offered to the user for review, with the resulting final flight plan being electronically filed with the FAA upon approval. In a further form, the user may arrange fuel transactions at intermediate destinations with the service provider receiving a fee in exchange for facilitating the transaction.

Abstract: The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases. We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is O; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.