Abstract: This disclosure relates to a method for controlling lubrication of a rotary shaft seal. The method involves providing an apparatus having a bulk lubricating oil reservoir, a rotary shaft that passes through the bulk lubricating oil reservoir, and a rotary shaft seal. The rotary shaft seal has a sealing edge in proximity with the rotary shaft creating a contact zone. The contact zone has a film of lubricating oil. The method also involves increasing the rate of heat flow along the rotary shaft to reduce temperature of the film of lubricating oil in the contact zone. Increasing the rate of heat flow along the rotary shaft is accomplished by using rotary shaft materials of construction having sufficient high thermal conductivity, rotary shaft coatings having sufficient high thermal conductivities, or increasing the surface area of the rotary shaft. This disclosure also relates to a method for controlling heat transfer in a contact zone, and a method for improving performance of an apparatus.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An endoscope comprises a handpiece housing, an elongate flexible shaft extending from the handpiece housing, a pull wire extending from the handpiece housing into the elongate flexible shaft, and a tensioning mechanism configured to adjust tension in the pull wire. A method for adjusting tension in a pull wire of a controller for an endoscope comprises preparing an endoscope for use before a procedure, adjusting tension in a pull wire for deflecting a flexible elongate shaft of the endoscope to reduce knob dwell, and performing an endoscopic procedure with the endoscope.

Abstract: Systems and methods for limiting functionality of a vehicle are described. In one example, vehicle feature modules may specify vehicle behaviors and vehicle operation is limited according to the specified behaviors. Vehicle actuators may be adjusted to limit vehicle operation according to the specified vehicle behaviors. The vehicle behaviors may apply to powertrain systems, navigation systems, climate control systems, lighting systems and other vehicle systems.

Abstract: In one embodiment, a method includes receiving a user input comprising a natural-language utterance by an assistant xbot from a client system associated with a user, determining a semantic representation of the user input based on a structural ontology defining a labeling syntax for parsing the natural-language utterance to semantic units comprising actions, objects, and attributes, wherein the semantic representation embeds at least one object within at least one action and declares at least one attribute of the embedded object to be acted upon, sending a request based on the semantic representation to an agent for executing a task corresponding to the user input, receiving results of the executed task mapped to a structure determined by the structural ontology from the agent, and sending from the assistant xbot to the client system instructions for presenting a response based on the results of the executed task.

Abstract: In one embodiment, a method includes receiving a user input comprising a natural-language utterance by an assistant xbot from a client system associated with a user, determining a semantic representation of the user input based on a structural ontology defining a labeling syntax for parsing the natural-language utterance to semantic units comprising actions, objects, and attributes, wherein the semantic representation embeds at least one object within at least one action and declares at least one attribute of the embedded object to be acted upon, sending a request based on the semantic representation to an agent for executing a task corresponding to the user input, receiving results of the executed task mapped to a structure determined by the structural ontology from the agent, and sending from the assistant xbot to the client system instructions for presenting a response based on the results of the executed task.

Abstract: An articulating medical device including handle and an articulating elongate member extending from the handle. The handle is a housing which includes at least one rotatable member, defining an arcuate track extending for a partial rotation about a center axis of rotation, at least one clamp captured, translatable, and rotatable within the arcuate track, and at least one articulation cable, fastened to the at least one clamp and extending outward from the handle, toward the articulating elongate member, including extending, when under tension, along a first lateral periphery of the at least one rotatable member and within a channel formed in the rotatable member. The at least one clamp translates within the arcuate track to accommodate slack in the at least one articulation cable when the at least one articulation cable is not under tension.

Abstract: An articulating medical device with a handle and an articulating elongate member extending from the handle. The handle has a cavity with at least one first rotatable member. The first rotatable member has a first lever arm and a first termination coupling. Coupled to the termination coupling is at least one first articulation cable. The first lever arm is arranged to limit displacement of slack in the at least one first articulation cable when the at least one first articulation cable is not under tension.

Abstract: In one embodiment, a method includes receiving a user input comprising a natural-language utterance by an assistant xbot from a client system associated with a user, determining a semantic representation of the user input based on a structural ontology defining a labeling syntax for parsing the natural-language utterance to semantic units comprising actions, objects, and attributes, wherein the semantic representation embeds at least one object within at least one action and declares at least one attribute of the embedded object to be acted upon, sending a request based on the semantic representation to an agent for executing a task corresponding to the user input, receiving results of the executed task mapped to a structure determined by the structural ontology from the agent, and sending from the assistant xbot to the client system instructions for presenting a response based on the results of the executed task.

Abstract: In one embodiment, a method includes receiving a user input comprising a natural-language utterance by an assistant xbot from a client system associated with a user, determining a semantic representation of the user input based on a structural ontology defining a labeling syntax for parsing the natural-language utterance to semantic units comprising actions, objects, and attributes, wherein the semantic representation embeds at least one object within at least one action and declares at least one attribute of the embedded object to be acted upon, sending a request based on the semantic representation to an agent for executing a task corresponding to the user input, receiving results of the executed task mapped to a structure determined by the structural ontology from the agent, and sending from the assistant xbot to the client system instructions for presenting a response based on the results of the executed task.

Abstract: A method for minimizing disturbance due to wind forces of a trailer being towed by a vehicle. The method also includes receiving, at a data processing hardware data from a sensor system for the tow vehicle. The method also includes determining, at the data processing hardware, a passing object profile. The method also includes predicting, at the data processing hardware, a wind force profile based upon the sensor data the passing object profile. The method also includes determining, at the data processing hardware, at least one preventative action for the vehicle to minimize the effect of disturbance on the trailer.

Abstract: In one embodiment, a method includes receiving a user input comprising a natural-language utterance by an assistant xbot from a client system associated with a user, determining a semantic representation of the user input based on a structural ontology defining a labeling syntax for parsing the natural-language utterance to semantic units comprising actions, objects, and attributes, wherein the semantic representation embeds at least one object within at least one action and declares at least one attribute of the embedded object to be acted upon, sending a request based on the semantic representation to an agent for executing a task corresponding to the user input, receiving results of the executed task mapped to a structure determined by the structural ontology from the agent, and sending from the assistant xbot to the client system instructions for presenting a response based on the results of the executed task.

Abstract: A cooking appliance includes an insulated cooking chamber positioned within a cabinet and an air plenum defined between the cabinet and the insulated cooking chamber. A fan assembly includes a first fan and a second fan positioned adjacent each other and having a void region immediately downstream of their outlets. The fan housings may be positioned in direct contact with each other such that the flows of cooling air exiting each fan interact with each other to reduce or eliminate expansion losses. Alternatively, the fan housings may be separated by a small airgap to reduce expansion losses while entraining additional cooling air.

Abstract: A material handler that uses chain driven magnetic plates to create a magnetic surface. The magnetic surface undulates and is able to lift ferrous material such as metal cans. The handler allows metal cans that are palletized to be removed quickly and easily.

Abstract: An oven appliance and flame arrester therefore are provided herein. The flame arrester may include a first member and a second member. The first member may extend in a lateral direction along a portion of the opening. The first member may define a chamber aperture extending along an arrest axis in fluid communication with the cooking chamber. The second member may extend from the first member and away from the cooking chamber. The second member may define an intake aperture extending non-parallel to the arrest axis. A fluid passage may be defined between the first member and the second member in fluid communication between the intake aperture and the chamber aperture.

Abstract: The present disclosure is directed to a personal vaporizing device having multiple methods for activating the personal vaporizing device. In one embodiment, the personal vaporizing device may be activated based on user preferences. In another embodiment, the personal vaporizing device may be activated based on an operating characteristic of the device and/or vaporizable material.

Abstract: A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gases containing nitric oxide are also described.

Abstract: A cooking appliance includes an insulated cooking chamber positioned within a cabinet and an air plenum defined between the cabinet and the insulated cooking chamber. A fan assembly includes a first fan and a second fan positioned adjacent each other and having a void region immediately downstream of their outlets. The fan housings may be positioned in direct contact with each other such that the flows of cooling air exiting each fan interact with each other to reduce or eliminate expansion losses. Alternatively, the fan housings may be separated by a small airgap to reduce expansion losses while entraining additional cooling air.

Abstract: The subject disclosure is directed towards running script through a malware detection system including an emulator environment to detect any malware within the script. Statistics are collected as part of processing the script, with parameterized heuristic analysis used to determine whether to run the emulation. The processing through the malware detection system may be iterative, to de-obfuscate layers of obfuscated malware. The emulator may be updated via signatures.

Abstract: An antimicrobial IV access cap having an inner surface for retaining an antimicrobial agent, and further configured to receive a portion of an access port of an intravascular device.