Abstract: The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.

Abstract: PDF inhibitors and novel methods for their use are provided.

Abstract: A method of using a cell library to create a device, includes projecting a series of masks, each mask of the series corresponding to a layer of each of one or more selected cells, onto a substrate according to a data layout of the device or combining a series of masks, each mask of the series corresponding to a layer of one or more of the selected cells, into a series of global masks, each of global masks of the series of global masks embodying a layer of the device according to a data layout of the device.

Abstract: A coating composition for paper and other substrates, particularly mechanical papers such as lightweight coated (LWC) paper, comprises an aqueous suspension of a particulate pigment together with a binder, wherein the particulate pigment comprises: (a) a first component which is a precipitated calcium carbonate consisting predominantly of aragonitic or rhombohedral particle shapes or of aragonitic and rhombohedral particle shapes in a weight ratio of between around 40:60 and about 60:40 (e.g.

Abstract: Abstract of the Disclosure The present invention relates to a hydrous kaolin product having improved optical properties, for example, when used in the production of paper products. The present invention comprises an improved barrier coating for paper and a method of making the coated paper. The present invention also comprises an improved method from making filled and coated paper products. The present invention uses a composition comprising kaolin having a shape factor of at least about 70:1, such as at least about 80:1 or at least about 100:1.

Abstract: There is provided a rinse added composition for the conditioning of fabric in a rinse, whereby the composition comprises a fabric softener active, a suds suppressing system and a surfactant scavenger, characterized in that the composition has a suds reduction value of at least about 90% and is free from visible flocs when used in the presence of residual detergent surfactant.

Abstract: There is provided a rinse added composition for the conditioning of fabric in a rinse, whereby the composition comprises a fabric softener active, a suds suppressing system and a surfactant scavenger, characterized in that the composition has a suds reduction value of at least about 90% and is free from visible flocs when used in the presence of residual detergent surfactant.

Abstract: The present invention relates to a hydrous kaolin product having improved optical properties, for example, when used in the production of paper products. The present invention comprises an improved barrier coating for paper and a method of making the coated paper. The present invention also comprises an improved method from making filled and coated paper products. The present invention uses a composition comprising kaolin having a shape factor of at least about 70:1, such as at least about 80:1 or at least about 100:1.

Abstract: An arm member mountable on a dipper stick of a machine and cooperative with an implement pivotally connected to the dipper stick for grappling articles between the arm member and the implement when the implement is pivoted towards the arm member generally consisting of an upper arm section pivotally connectable to an underside of the dipper for pivotal movement about a first axis substantially parallel to the pivot axis of the implement, a lower section connected to the upper section for pivotal movement relative to the upper section about a second axis lying in a plane disposed substantially perpendicular to the first axis, a mechanism interconnecting the arm sections for biasing the arm sections into longitudinal alignment with each other, including means for retarding the biasing action thereof, and means for suspending the free end of the lower arm section from the underside of the dipper stick, cooperable with such implement when such implement is pivoted toward the suspension means for grappling article

Abstract: The present invention relates to a hydrous kaolin product having improved optical properties, for example, when used in the production of paper products. The present invention comprises an improved barrier coating for paper and a method of making the coated paper. The present invention also comprises an improved method from making filled and coated paper products. The present invention uses a composition comprising kaolin having a shape factor of at least about 70:1, such as at least about 80:1 or at least about 100:1.

Abstract: The present invention relates to a hydrous kaolin product having improved optical properties, for example, when used in the production of paper products. The present invention comprises an improved barrier coating for paper and a method of making the coated paper. The present invention also comprises an improved method from making filled and coated paper products. The present invention uses a composition comprising kaolin having a shape factor of at least about 70:1, such as at least about 80:1 or at least about 100:1.

Abstract: A module for a frame for a motor vehicle with a pair of laterally spaced, longitudinally extending central side rail structures. The module including a pair of tubular hydroformed side rail members and a laterally extending connecting structure connected between the pair of side rail members to secure the pair of side rail members in laterally spaced, fixed relation to one another. Each first portion of the pair of side rail members extending longitudinally and each second portion of the pair of side rail members extending laterally relative to the respective first portion and each second portion having an end being constructed and arranged to form a joint with a portion of a respective central side rail structure such that the end of each of the pair of side rail members extends generally laterally through a side of the respective central side rail structure.

Abstract: The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.

Abstract: PDF inhibitors and novel methods for their use are provided.

Abstract: PDF inhibitors and novel methods for their use are provided.

Abstract: A package for prolonging the storage life of produce is disclosed. The package comprises a gas permeable container and an atmosphere modifying device contained within the container. The atmosphere modifying device comprises a carbon dioxide emitter, an oxygen scavenger, and an optional ethylene scavenger. Produce is stored in the container with the device. The device and container are suitable to use in a consumer's home (e.g., kitchen cabinet or refrigerator).

Abstract: The present invention involves novel anti-bacterial compounds represented by Formula (I) hereinbelow and their use as PDF inhibitors.

Abstract: PDF inhibitors and novel methods for their use are provided.

Abstract: The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Abstract: The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.