Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Abstract: Systems and methods for matching content elements to surfaces in a spatially organized 3D environment. The method includes receiving content, identifying one or more elements in the content, determining one or more surfaces, matching the one or more elements to the one or more surfaces, and displaying the one or more elements as virtual content onto the one or more surfaces.

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Abstract: A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.

Abstract: A method for activating a catalyst is described comprising the steps of: (i) installing a reduced and passivated catalyst containing crystallites of a catalytic metal comprising nickel, cobalt or iron in elemental form encapsulated by a layer comprising an oxide of the catalytic metal in a reactor, such as a steam methane reforming reactor, in which it is to be used, and (ii) heating the reduced and passivated catalyst in the reactor under a vacuum or an inert gas to a temperature in the range (TT?X) to (TT+Y), where TT is the Tammann temperature of the catalytic metal in elemental form in degrees Centigrade, X is 400 and Y is 200, to form a catalytically active surface on the catalyst without requiring the application of a reducing gas.

Abstract: In a method or system in which an imaging element views navigation elements for e.g. navigation, the navigating elements may not be positioned optimally. Positions may exist in which the same angles exist from the imaging element to the same or similar navigating elements, whereby the positions are not unique. Navigation elements may then be repositioned, added or removed to make the positions unique.

Abstract: An interfacing structure for a mask system includes a cushion component adapted to contact the patient's face in use and a cushion-to-frame component provided to the cushion component. The cushion-to-frame component is structured to secure the cushion component to a mask frame of the mask system. The cushion-to-frame component includes a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame. The cushion side includes a platform to engage and support the cushion component. The platform provides an engagement surface to engage the cushion component and inner and outer flanges provided to opposing ends of the platform to guide, support and/or retain the cushion component on the platform.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A fan device used with respect to a computing device. The fan device includes at least two fans that provide airflow for the computing device and a controller that adjusts the fans' speeds in an attempt to avoid harmonic vibrations of the at least two fans. The fan device may include at least one sensor, and the controller may adjust the fans' speeds based at least on information from the sensor(s) in the attempt to avoid the harmonic vibrations. The attempt to avoid the harmonic vibrations may also attempt to mitigate one or more of turbulence, pressure, over-heating, power consumption, or noise in, by, or around the computing device. Reversal of airflow may also be used. A fan bar that enables isolation of ground return noise may also be used. The controller may use sums of primes calculations, phase analysis, common divisor calculations, and the like. Also, associated methods.

Abstract: A slot milling sequence includes a plurality of material removal processes or operations. Each of the material removal operations includes utilization of an end mill tool. Some of the material removal operations utilize trochoidal tool paths, whereas other material removal processes utilize one or more profile cuts. Some material removal operations that utilize profile cuts remove material from both sides of the cut in a single pass, whereas other material removal operations remove material from one side of the cut via a first pass of the end mill tool and remove material from the opposing side of the cut via a second pass of the end mill tool.

Abstract: There is provided a display screen configurable via optical signals to display an image. The display screen is formed of an optical waveguide having a display surface and supporting a plurality of pixels for displaying the image on the display surface of the optical waveguide. The optical waveguide is arranged to guide a multiplexed signal in optical form to a plurality of pixel controllers, each coupled to at least one of the pixels and configured to demultiplex the multiplexed signal and thereby extract a component signal associated with the at least one pixel for controlling it to render an element of the image.

Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.

Abstract: Among other things, embodiments of the present disclosure provide systems and methods for modifying avatar components of avatar datasets for multiple users, generating avatars based on the datasets, and displaying multiple avatars on a display screen of a graphical user interface.

Abstract: An apparatus and method for manufacturing an elastic composite structure for an absorbent sanitary product includes a bonding unit configured to bond a first web layer to a second web layer via a bond pattern that includes at least one bond line having at least one pair of adjacent bonds. The bonding unit secures an elastic thread within a passage defined by the at least one pair of adjacent bonds. The passage has a cross-sectional area smaller than a cross-sectional area of the elastic thread in a non-tensioned state.

Abstract: An apparatus and method for forming a tubular masking tape from a planar masking tape easily and quickly. The apparatus includes an elongated frame having a proximal end and a distal end. A tape head is coupled over the distal end. A tape roll of the planar masking tape can be mounted to the tape head. A roller ASSY is spatially positioned above the top side of the frame, wherein the roller ASSY includes an upper roller and a lower roller positioned one above another. A die is mounted over the top side of the frame spatially between the tape head and the roller ASSY. A leading edge from the tape roll is passed through a slot in the die and thereafter the curved leading edge from the slot is pressed between the rollers of the roller assy.

Abstract: A method of using a mechanical joint restraint includes inserting an end of a pipe length into a gland bore of a gland, a ring bore of a gripping ring, and a gasket bore of a gasket, the gland, the gripping ring, and the gasket together forming the mechanical joint restraint; inserting at least a portion of the gasket of the mechanical joint restraint into a socket of a piping element; inserting the end of the pipe length into the socket of the piping element; and drawing the gland towards a flange of the piping element to compress the gasket into sealing engagement with the piping element and the pipe length.

Abstract: Embodiments of the invention provide a hollow cable for transmitting radiofrequency and/or microwave frequency energy to an electrosurgical instrument, wherein the hollow cable is provided with electrical connectors for forming a bipolar electrical connection with an electrosurgical instrument that fits within, e.g. slides relative to, the hollow cable. The connectors can be conductive protrusions extending in an axial direction on opposite sides of the cable. The protrusions can be tabs, fins, rods, pins, or wires. The protrusions can be strips which engage corresponding terminals on the instrument. The transmission line structure of the invention can have a greater diameter then convention coaxial cables, which can minimise loss whilst still providing access for control wires and/or fluid to reach an surgical instrument. The cable can be used with multiple instruments.

Abstract: A docking station for a medical device is described. In some examples, the docking station includes a frame and a base plate coupled to the frame. At least a portion of the base plate is coupled to a lower portion of the frame. In some examples, an electronic connector of the docking station is configured to couple to the medical device and to provide power to the medical device when the medical device is docked to the docking station. In some examples, a docking mechanism is coupled to an upper portion of the frame and configured to retain the medical device.

Abstract: In one aspect of the present disclosure, a disc brake rotor assembly is provided that includes a disc brake rotor and a wheel hub. One of the disc brake rotor and the wheel hub includes a plurality of pairs of partial keyways and the other of the disc brake rotor and the wheel hub includes intermediate partial keyways configured to fit intermediate the pairs of partial keyways to form keyways. The disc brake rotor assembly further includes a plurality of fasteners configured to be received in the keyways to secure the disc brake rotor and the wheel hub together.

Abstract: A circuit board assembly includes an electrical connector mounted to a circuit board having a connector housing holding contacts in a contact array. A connector mount having a bracket is coupled to the mounting surface of the circuit board proximate to the mating edge. The electrical connector is movably coupled to the connector mount to move relative to the circuit board during mating with the mating electrical connector. The connector mount has a biasing member compressible along a compression axis parallel to the mating direction to allow the electrical connector to float in the mating direction relative to the circuit board. The electrical connector is movably coupled to the connector mount in a confined envelope in at least one floating direction perpendicular to the mating direction.