Abstract: A method for operating a shaking machine, in particular for optimizing an operating state of the shaking machine, including shaking at least one shaking material in at least one shaking vessel; setting at least one target operating parameter to at least one target value or one target range; detecting an adjustment range of at least one additional operating parameter; determining an operating state by means of an optimizer that varies at least one adjustable operating parameter and by using at least one model, such that at least one target operating parameter maintains, achieves, or approaches the target value or target range, wherein at least one operating state of the shaking machine is imaged by at least one model.

Abstract: A loyalty system, loyalty tracking system, merchant multi-use loyalty system, merchant offering platform, loyalty sharing system, loyalty platform, sharing network platform, commercial incentivising system, and methods of use are presented. The present loyalty system provides for a system with many features including the ability to share loyalties earned with other users. Furthermore, the system provides for maintaining access to loyalties even if shared. The loyalty system provides for an incentive program. Furthermore, the present disclosure provides for various covid features enabling operation of restaurants and other merchants, and the like.

Abstract: The invention relates to a method for controlling the temperature of reaction mixtures (2) in an agitation operation, wherein at least two reaction mixtures (2) in at least two reaction vessels (1) are individually temperature-controlled, said reaction mixtures (2) in said reaction vessels (1) being subjected to a common agitation movement (3), the individual temperature control of at least two reaction mixtures (2) being carried out by means of a separate heat transfer (6) between each at least one reaction mixture (2) and at least one temperature control zone (4) associated with said reaction mixture (2).

Abstract: A method for metering and storing liquids by means of a permanently open container (1), wherein: the container (1) comprises a liquid reservoir (11) in which at least one liquid (2) is contained for storage; the container (1) has at least one opening (15) for the metered discharging of the liquid from the liquid reservoir (11); the opening (15) is permanently open; influencing factors affect at least one change in pressure (4) in the container (1); influencing factors render the system formed of the container (1) and liquid (2) unstable; the pressure (4) is detected in at least one location in the container (1); and, subject to at least one detected change in pressure (4), at least one reaction (9) is initiated that is suitable for maintaining the system of the container (1) and liquid (2) in a stable state or for re-establishing this stable state.

Abstract: An integrated device package is disclosed. The integrated device package can include a substrate that has an upper side and a lower side opposite the upper side. The integrated device package can include an integrated device die that is mounted to the lower side of the substrate. The integrated device die has a first side facing the lower side of the substrate and a second side opposite the first side. The package can include a molding material in which the integrated device die is at least partially embedded. The package can include a thermally conductive element coupled to the second side of the integrated device die. At least a portion of the thermally conductive element can be exposed through the molding material. The thermally conductive element can be a heat sink. The package can include an interconnect that is configured to provide an external connection. The interconnect extends at least partially through the molding material from the lower side of the substrate.

Abstract: In one aspect, an electric coil structure is disclosed. The electric coil structure includes a magnetic core and a substrate. The substrate comprises a conductive material that is embedded in an insulating material. The substrate has a first portion and a second portion and the first portion of the substrate is wrapped around the core. The substrate can have a first portion having a plurality of contacts and a second portion having a corresponding plurality of edge contacts. The coil structure includes an alignment structure. The alignment structure can facilitate attachment of the first portion to the second portion to define a coil about the magnetic core. The alignment structure can comprise a redistribution substrate. The redistribution substrate can be disposed between the first portion and the second portion with the conductive material of the first portion electrically connected to the conductive material of the second portion through the redistribution substrate to define at least one winding.

Abstract: Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/or treating various conditions, disorders or diseases. In some embodiments, provided oligonucleotides comprise nucleobase modifications, sugar modifications, internucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, the present disclosure provides oligonucleotides, compositions and methods for HTT-related conditions, disorders or diseases, such as Huntington's disease.

Abstract: The present invention relates to a combination of a signal transducer and activator of transcription 3 (STAT3) activity inhibitor; and an immune checkpoint inhibitor for use in treating or preventing the hyperproliferative disorder in a subject. Preferably, the STA3 activity inhibitor is pyrimethamine or atovaquone, and the immune checkpoint inhibitor is an anti-PD1 antibody. Preferably, the hyperproliferative disorder is a glioma or a glioblastoma.

Abstract: A flow control system is disclosed. The flow control system can include a flow meter positioned at a first location of a flow path of a fluid substance, and a valve positioned at a second location of the flow path of the fluid substance. The flow meter can include a molded non-conductive housing, a heating element that is at least partially embedded in the housing, and a sensing element that is at least partially embedded in the housing. The valve can open the flow path to allow the fluid substance to flow in the flow path. The valve can include an actuator that includes deformable chamber and a gate in the flow path of the fluid substance.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: An electronic module is disclosed. The electronic module can include a package substrate, an integrated device die, a dam structure, and a mounting compound. The integrated device die can have an upper side, a lower side, and an outer side edge. The dam structure can have a first sidewall and a second sidewall opposite the first sidewall. The second sidewall can be nearer to the outer side edge than the first sidewall. The first sidewall can be laterally positioned between a center of the lower side of the integrated device die and the outer side edge. The dam structure can be disposed between a portion of the package substrate and a portion of the lower side of the integrated device die. The mounting compound can be disposed between the lower side of the integrated device die and the package substrate.

Abstract: A sensor module for a wearable vital sign monitoring device is disclosed. The sensor module includes a substrate having a first side and a second side opposite the first side. The sensor module also includes a sensor die mounted to the first side of the substrate. The sensor die is configured to monitor a vital sign of a user. The sensor module further includes a waterproof coating that conformally covers the sensor die, at least a portion of the first side of the substrate, and at least a portion of the second side of the substrate.

Abstract: The present invention relates to compositions and methods for treating cancer with harmine.

Abstract: The present invention relates to compositions and methods for treating cancer with targeted mineralocorticoid analogues

Abstract: The present disclosure provides (i) RNA-guided polypeptides (e.g., circular permuted Cas9 proteins) in which the N-terminal end of an N-terminal fragment of a parent RNA-guided polypeptide (e.g., a parent Cas9 protein) is fused (e.g., via linker) to the C-terminal end of the C-terminal fragment (thereby generating new N- and C-termini), (ii) conditionally active RNA-guided polypeptides (e.g., conditionally active circular permuted Cas9 proteins), and (iiii) Cas9 fusion polypeptides that include an internal insertion of a heterologous polypeptide; as well as methods that employ the above polypeptides.

Abstract: A substance delivery device is disclosed. The substance delivery device includes a lever that includes a drive arm that is rotatable about a pivot. The substance delivery device also includes a pump that has a deformable chamber. The deformable chamber is configured to rotate the drive arm about the pivot towards a container so as to deform the container to drive a fluid substance from the container.

Abstract: A method of root cause diagnosis of fault data from a vehicle includes identifying a first vehicle fault and selecting from field repair data a vehicle feature corresponding to the identified first vehicle fault. The method also includes identifying from the field repair data an effective repair of the identified first vehicle fault. The method additionally includes training and testing via a machine learning algorithm, a labor code classifier using the identified effective repair of the first vehicle fault and the selected vehicle feature corresponding to the identified first vehicle fault. The method also includes identifying and classifying, using the trained classifier, indistinguishable labor codes. Furthermore, the method includes communicating the identified and classified indistinguishable labor codes for diagnosing a root cause of real time first vehicle fault data.

Abstract: The present disclosure provides an RNA-guided effector polypeptide having a length that is less than Streptococcus pyogenes Cas9, and that retains the ability, when complexed with a guide RNA, to bind to a target nucleic acid. The present disclosure provides a fusion polypeptide comprising: i) an RNA-guided effector polypeptide of the present disclosure; and ii) a fusion partner. The present disclosure further provides nucleic acids encoding an RNA-guided effector polypeptide, or a fusion polypeptide, of the present disclosure. Methods of using an RNA-guided effector polypeptide, or a fusion polypeptide, of the present disclosure are also provided.

Abstract: In some embodiments, an electronic module is disclosed. The electronic module can include a carrier and an integrated device die having an upper surface, a lower surface, and an outer side edge. The integrated device die can include a first surface recessed from the lower surface and a second surface extending between the lower surface and the first surface. The second surface can be laterally inset from the outer side edge. The electronic module can include a mounting compound comprising a first portion disposed between the lower surface of the integrated device die and the carrier and a second portion disposed along at least a portion of the second surface of the integrated device die.

Abstract: Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.